31 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCL20	C-C motif chemokine. (96 aa)
	IL6	Interleukin 6. (214 aa)
	TLR1	Toll-like receptor. (786 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	HLA-G	IGc1 domain-containing protein; Belongs to the MHC class I family. (354 aa)
	TLR2	Toll-like receptor. (784 aa)
	CD40	CD40 molecule. (278 aa)
	PRF1	Perforin. (555 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
	CD80	CD80 molecule. (288 aa)
	IRF7	Interferon regulatory factor 7. (504 aa)
	GZMB	Granzyme B; Belongs to the peptidase S1 family. (281 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1063 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	CD86	CD86 molecule. (329 aa)
	IRF1	Interferon regulatory factor. (325 aa)
	STAT2	Signal transducer and activator of transcription. (852 aa)
	TIMP1	TIMP metallopeptidase inhibitor 1. (207 aa)
	CDC42	Uncharacterized protein. (191 aa)
	CCL5	C-C motif chemokine. (91 aa)
	MMP9	Matrix metallopeptidase 9. (694 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	IRF3	Interferon regulatory factor 3. (422 aa)
	CCL2	C-C motif chemokine. (99 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	CXCL11	C-X-C motif chemokine. (96 aa)
	CXCL10	C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CCL20	ENSMNEP00000030968	ENSMNEP00000037448	C-C motif chemokine.	C-C motif chemokine.	0.646
CCL2	CCL5	ENSMNEP00000030968	ENSMNEP00000021616	C-C motif chemokine.	C-C motif chemokine.	0.966
CCL2	CD4	ENSMNEP00000030968	ENSMNEP00000040289	C-C motif chemokine.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.743
CCL2	CD40	ENSMNEP00000030968	ENSMNEP00000002207	C-C motif chemokine.	CD40 molecule.	0.640
CCL2	CD80	ENSMNEP00000030968	ENSMNEP00000008421	C-C motif chemokine.	CD80 molecule.	0.543
CCL2	CD86	ENSMNEP00000030968	ENSMNEP00000015397	C-C motif chemokine.	CD86 molecule.	0.593
CCL2	CXCL10	ENSMNEP00000030968	ENSMNEP00000046238	C-C motif chemokine.	C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	0.893
CCL2	CXCL11	ENSMNEP00000030968	ENSMNEP00000041835	C-C motif chemokine.	C-X-C motif chemokine.	0.732
CCL2	IL15	ENSMNEP00000030968	ENSMNEP00000033614	C-C motif chemokine.	Interleukin; Belongs to the IL-15/IL-21 family.	0.703
CCL2	IL1B	ENSMNEP00000030968	ENSMNEP00000033521	C-C motif chemokine.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.850
CCL2	IL6	ENSMNEP00000030968	ENSMNEP00000000727	C-C motif chemokine.	Interleukin 6.	0.939
CCL2	IRF1	ENSMNEP00000030968	ENSMNEP00000016345	C-C motif chemokine.	Interferon regulatory factor.	0.418
CCL2	IRF3	ENSMNEP00000030968	ENSMNEP00000027938	C-C motif chemokine.	Interferon regulatory factor 3.	0.514
CCL2	MMP9	ENSMNEP00000030968	ENSMNEP00000022445	C-C motif chemokine.	Matrix metallopeptidase 9.	0.569
CCL2	STAT1	ENSMNEP00000030968	ENSMNEP00000001128	C-C motif chemokine.	Signal transducer and activator of transcription.	0.639
CCL2	STAT2	ENSMNEP00000030968	ENSMNEP00000020511	C-C motif chemokine.	Signal transducer and activator of transcription.	0.462
CCL2	TIMP1	ENSMNEP00000030968	ENSMNEP00000020744	C-C motif chemokine.	TIMP metallopeptidase inhibitor 1.	0.623
CCL2	TLR1	ENSMNEP00000030968	ENSMNEP00000000905	C-C motif chemokine.	Toll-like receptor.	0.511
CCL2	TLR2	ENSMNEP00000030968	ENSMNEP00000001573	C-C motif chemokine.	Toll-like receptor.	0.625
CCL2	TLR3	ENSMNEP00000030968	ENSMNEP00000014289	C-C motif chemokine.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.588