8 items (Macaca nemestrina) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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gene neighborhood

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protein homology

Your Input:
	TLR1	Toll-like receptor. (786 aa)
	TLR2	Toll-like receptor. (784 aa)
	LY96	MD-2. (160 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
	IL6	Interleukin 6. (214 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL1B	IL6	ENSMNEP00000033521	ENSMNEP00000000727	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Interleukin 6.	0.932
IL1B	LY96	ENSMNEP00000033521	ENSMNEP00000006245	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	MD-2.	0.411
IL1B	MYD88	ENSMNEP00000033521	ENSMNEP00000032156	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.836
IL1B	TLR1	ENSMNEP00000033521	ENSMNEP00000000905	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Toll-like receptor.	0.697
IL1B	TLR2	ENSMNEP00000033521	ENSMNEP00000001573	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Toll-like receptor.	0.767
IL1B	TLR3	ENSMNEP00000033521	ENSMNEP00000014289	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.670
IL1B	TLR4	ENSMNEP00000033521	ENSMNEP00000035110	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.778
IL6	IL1B	ENSMNEP00000000727	ENSMNEP00000033521	Interleukin 6.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.932
IL6	LY96	ENSMNEP00000000727	ENSMNEP00000006245	Interleukin 6.	MD-2.	0.418
IL6	MYD88	ENSMNEP00000000727	ENSMNEP00000032156	Interleukin 6.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.715
IL6	TLR1	ENSMNEP00000000727	ENSMNEP00000000905	Interleukin 6.	Toll-like receptor.	0.667
IL6	TLR2	ENSMNEP00000000727	ENSMNEP00000001573	Interleukin 6.	Toll-like receptor.	0.747
IL6	TLR3	ENSMNEP00000000727	ENSMNEP00000014289	Interleukin 6.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.725
IL6	TLR4	ENSMNEP00000000727	ENSMNEP00000035110	Interleukin 6.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.832
LY96	IL1B	ENSMNEP00000006245	ENSMNEP00000033521	MD-2.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.411
LY96	IL6	ENSMNEP00000006245	ENSMNEP00000000727	MD-2.	Interleukin 6.	0.418
LY96	MYD88	ENSMNEP00000006245	ENSMNEP00000032156	MD-2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.977
LY96	TLR1	ENSMNEP00000006245	ENSMNEP00000000905	MD-2.	Toll-like receptor.	0.904
LY96	TLR2	ENSMNEP00000006245	ENSMNEP00000001573	MD-2.	Toll-like receptor.	0.898
LY96	TLR3	ENSMNEP00000006245	ENSMNEP00000014289	MD-2.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.864