8 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POMC	Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. (265 aa)
	TLR1	Toll-like receptor. (786 aa)
	IL6	Interleukin 6. (214 aa)
	CSTA	Cystatin A; Belongs to the cystatin family. (98 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
	IGFBP1	Insulin like growth factor binding protein 1. (281 aa)
	TLR2	Toll-like receptor. (784 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSTA	IGFBP1	ENSMNEP00000022851	ENSMNEP00000021379	Cystatin A; Belongs to the cystatin family.	Insulin like growth factor binding protein 1.	0.568
IGFBP1	CSTA	ENSMNEP00000021379	ENSMNEP00000022851	Insulin like growth factor binding protein 1.	Cystatin A; Belongs to the cystatin family.	0.568
IL1B	IL6	ENSMNEP00000033521	ENSMNEP00000000727	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Interleukin 6.	0.932
IL1B	TLR1	ENSMNEP00000033521	ENSMNEP00000000905	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Toll-like receptor.	0.697
IL1B	TLR2	ENSMNEP00000033521	ENSMNEP00000001573	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Toll-like receptor.	0.767
IL1B	TLR4	ENSMNEP00000033521	ENSMNEP00000035110	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.778
IL6	IL1B	ENSMNEP00000000727	ENSMNEP00000033521	Interleukin 6.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.932
IL6	TLR1	ENSMNEP00000000727	ENSMNEP00000000905	Interleukin 6.	Toll-like receptor.	0.667
IL6	TLR2	ENSMNEP00000000727	ENSMNEP00000001573	Interleukin 6.	Toll-like receptor.	0.747
IL6	TLR4	ENSMNEP00000000727	ENSMNEP00000035110	Interleukin 6.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.832
TLR1	IL1B	ENSMNEP00000000905	ENSMNEP00000033521	Toll-like receptor.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.697
TLR1	IL6	ENSMNEP00000000905	ENSMNEP00000000727	Toll-like receptor.	Interleukin 6.	0.667
TLR1	TLR2	ENSMNEP00000000905	ENSMNEP00000001573	Toll-like receptor.	Toll-like receptor.	0.999
TLR1	TLR4	ENSMNEP00000000905	ENSMNEP00000035110	Toll-like receptor.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.845
TLR2	IL1B	ENSMNEP00000001573	ENSMNEP00000033521	Toll-like receptor.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.767
TLR2	IL6	ENSMNEP00000001573	ENSMNEP00000000727	Toll-like receptor.	Interleukin 6.	0.747
TLR2	TLR1	ENSMNEP00000001573	ENSMNEP00000000905	Toll-like receptor.	Toll-like receptor.	0.999
TLR2	TLR4	ENSMNEP00000001573	ENSMNEP00000035110	Toll-like receptor.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.976
TLR4	IL1B	ENSMNEP00000035110	ENSMNEP00000033521	Toll like receptor 4; Belongs to the Toll-like receptor family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.778
TLR4	IL6	ENSMNEP00000035110	ENSMNEP00000000727	Toll like receptor 4; Belongs to the Toll-like receptor family.	Interleukin 6.	0.832