23 items (Macaca nemestrina) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
	IL6	Interleukin 6. (214 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (409 aa)
	MRC1	Mannose receptor C-type 1. (1456 aa)
	TSPO	Translocator protein. (169 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	CCL17	C-C motif chemokine. (91 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	CCL5	C-C motif chemokine. (91 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (123 aa)
	CCL2	C-C motif chemokine. (99 aa)
	CD68	CD68 molecule. (354 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
	IL17A	Interleukin 17A. (155 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	CXCL10	C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL17	CCL2	ENSMNEP00000017772	ENSMNEP00000030968	C-C motif chemokine.	C-C motif chemokine.	0.588
CCL17	CCL5	ENSMNEP00000017772	ENSMNEP00000021616	C-C motif chemokine.	C-C motif chemokine.	0.996
CCL17	CCR7	ENSMNEP00000017772	ENSMNEP00000012848	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.857
CCL17	CXCL10	ENSMNEP00000017772	ENSMNEP00000046238	C-C motif chemokine.	C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	0.721
CCL17	IFNG	ENSMNEP00000017772	ENSMNEP00000045088	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.476
CCL17	IL10	ENSMNEP00000017772	ENSMNEP00000036763	C-C motif chemokine.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.643
CCL17	IL1B	ENSMNEP00000017772	ENSMNEP00000033521	C-C motif chemokine.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.404
CCL17	IL4	ENSMNEP00000017772	ENSMNEP00000020267	C-C motif chemokine.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.596
CCL17	IL6	ENSMNEP00000017772	ENSMNEP00000000727	C-C motif chemokine.	Interleukin 6.	0.508
CCL2	CCL17	ENSMNEP00000030968	ENSMNEP00000017772	C-C motif chemokine.	C-C motif chemokine.	0.588
CCL2	CCL5	ENSMNEP00000030968	ENSMNEP00000021616	C-C motif chemokine.	C-C motif chemokine.	0.966
CCL2	CCR7	ENSMNEP00000030968	ENSMNEP00000012848	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.869
CCL2	CD68	ENSMNEP00000030968	ENSMNEP00000031272	C-C motif chemokine.	CD68 molecule.	0.683
CCL2	CXCL10	ENSMNEP00000030968	ENSMNEP00000046238	C-C motif chemokine.	C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	0.893
CCL2	GAPDH	ENSMNEP00000030968	ENSMNEP00000034499	C-C motif chemokine.	Glyceraldehyde-3-phosphate dehydrogenase.	0.452
CCL2	IFNG	ENSMNEP00000030968	ENSMNEP00000045088	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.876
CCL2	IL10	ENSMNEP00000030968	ENSMNEP00000036763	C-C motif chemokine.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.882
CCL2	IL15	ENSMNEP00000030968	ENSMNEP00000033614	C-C motif chemokine.	Interleukin; Belongs to the IL-15/IL-21 family.	0.703
CCL2	IL17A	ENSMNEP00000030968	ENSMNEP00000035713	C-C motif chemokine.	Interleukin 17A.	0.562
CCL2	IL1B	ENSMNEP00000030968	ENSMNEP00000033521	C-C motif chemokine.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.850