node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOE | FGF2 | ENSMNEP00000017988 | ENSMNEP00000045834 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.436 |
APOE | IL1B | ENSMNEP00000017988 | ENSMNEP00000033521 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.576 |
APOE | IL6 | ENSMNEP00000017988 | ENSMNEP00000000727 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Interleukin 6. | 0.556 |
APOE | LDLR | ENSMNEP00000017988 | ENSMNEP00000000107 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Low density lipoprotein receptor. | 0.601 |
APOE | PPARG | ENSMNEP00000017988 | ENSMNEP00000007307 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.605 |
APOE | TLR4 | ENSMNEP00000017988 | ENSMNEP00000035110 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.478 |
BMP4 | FGF2 | ENSMNEP00000026047 | ENSMNEP00000045834 | Bone morphogenetic protein 4. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.671 |
BMP4 | MSX2 | ENSMNEP00000026047 | ENSMNEP00000025194 | Bone morphogenetic protein 4. | Msh homeobox 2. | 0.481 |
BMP4 | WNT3A | ENSMNEP00000026047 | ENSMNEP00000027488 | Bone morphogenetic protein 4. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.635 |
BMP4 | WNT7A | ENSMNEP00000026047 | ENSMNEP00000028117 | Bone morphogenetic protein 4. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.498 |
CDH11 | SOX9 | ENSMNEP00000042432 | ENSMNEP00000039074 | Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins. | SRY-box transcription factor 9. | 0.419 |
COL2A1 | MSX2 | ENSMNEP00000020889 | ENSMNEP00000025194 | Collagen type II alpha 1 chain. | Msh homeobox 2. | 0.435 |
COL2A1 | SOX9 | ENSMNEP00000020889 | ENSMNEP00000039074 | Collagen type II alpha 1 chain. | SRY-box transcription factor 9. | 0.715 |
COL2A1 | WNT7A | ENSMNEP00000020889 | ENSMNEP00000028117 | Collagen type II alpha 1 chain. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.572 |
ELN | TGFB1 | ENSMNEP00000010878 | ENSMNEP00000039914 | Elastin. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.500 |
FGF2 | APOE | ENSMNEP00000045834 | ENSMNEP00000017988 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.436 |
FGF2 | BMP4 | ENSMNEP00000045834 | ENSMNEP00000026047 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Bone morphogenetic protein 4. | 0.671 |
FGF2 | IL1B | ENSMNEP00000045834 | ENSMNEP00000033521 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.560 |
FGF2 | IL6 | ENSMNEP00000045834 | ENSMNEP00000000727 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Interleukin 6. | 0.587 |
FGF2 | TGFB1 | ENSMNEP00000045834 | ENSMNEP00000039914 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.574 |