29 items (Macaca nemestrina) - STRING interaction network

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Your Input:
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	CXCL9	C-X-C motif chemokine ligand 9. (125 aa)
	IL6	Interleukin 6. (214 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	PRF1	Perforin. (555 aa)
	CCR9	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	IL22	Interleukin 22. (179 aa)
	MPO	Myeloperoxidase. (797 aa)
	CCR5	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (409 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	CCL5	C-C motif chemokine. (91 aa)
	FOXP3	Forkhead box P3. (456 aa)
	IL7	Interleukin 7. (184 aa)
	CCL2	C-C motif chemokine. (99 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	CCL20	C-C motif chemokine. (96 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (403 aa)
	CD38	CD38 molecule. (301 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	CCL25	C-C motif chemokine ligand 25. (165 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	CCL21	C-C motif chemokine ligand 21. (131 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
	CCL19	C-C motif chemokine. (123 aa)
	CXCL10	C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL19	CCL2	ENSMNEP00000046138	ENSMNEP00000030968	C-C motif chemokine.	C-C motif chemokine.	0.406
CCL19	CCL21	ENSMNEP00000046138	ENSMNEP00000043476	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.995
CCL19	CCL25	ENSMNEP00000046138	ENSMNEP00000041302	C-C motif chemokine.	C-C motif chemokine ligand 25.	0.851
CCL19	CCL5	ENSMNEP00000046138	ENSMNEP00000021616	C-C motif chemokine.	C-C motif chemokine.	0.499
CCL19	CCR5	ENSMNEP00000046138	ENSMNEP00000012525	C-C motif chemokine.	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	0.912
CCL19	CCR9	ENSMNEP00000046138	ENSMNEP00000008965	C-C motif chemokine.	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	0.912
CCL19	CD4	ENSMNEP00000046138	ENSMNEP00000040289	C-C motif chemokine.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.599
CCL19	CXCL10	ENSMNEP00000046138	ENSMNEP00000046238	C-C motif chemokine.	C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	0.692
CCL19	CXCL9	ENSMNEP00000046138	ENSMNEP00000000488	C-C motif chemokine.	C-X-C motif chemokine ligand 9.	0.828
CCL19	CXCR4	ENSMNEP00000046138	ENSMNEP00000017146	C-C motif chemokine.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.921
CCL19	IFNG	ENSMNEP00000046138	ENSMNEP00000045088	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.469
CCL2	CCL19	ENSMNEP00000030968	ENSMNEP00000046138	C-C motif chemokine.	C-C motif chemokine.	0.406
CCL2	CCL20	ENSMNEP00000030968	ENSMNEP00000037448	C-C motif chemokine.	C-C motif chemokine.	0.646
CCL2	CCL25	ENSMNEP00000030968	ENSMNEP00000041302	C-C motif chemokine.	C-C motif chemokine ligand 25.	0.518
CCL2	CCL5	ENSMNEP00000030968	ENSMNEP00000021616	C-C motif chemokine.	C-C motif chemokine.	0.966
CCL2	CCR5	ENSMNEP00000030968	ENSMNEP00000012525	C-C motif chemokine.	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	0.982
CCL2	CCR9	ENSMNEP00000030968	ENSMNEP00000008965	C-C motif chemokine.	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	0.806
CCL2	CD4	ENSMNEP00000030968	ENSMNEP00000040289	C-C motif chemokine.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.743
CCL2	CXCL10	ENSMNEP00000030968	ENSMNEP00000046238	C-C motif chemokine.	C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	0.893
CCL2	CXCL9	ENSMNEP00000030968	ENSMNEP00000000488	C-C motif chemokine.	C-X-C motif chemokine ligand 9.	0.979