node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DEFB125 | DEFB128 | ENSMNEP00000035258 | ENSMNEP00000024003 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | 0.808 |
DEFB125 | DEFB135 | ENSMNEP00000035258 | ENSMNEP00000013391 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | 0.860 |
DEFB125 | NLRC5 | ENSMNEP00000035258 | ENSMNEP00000025631 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | NLR family CARD domain containing 5. | 0.639 |
DEFB125 | NOD2 | ENSMNEP00000035258 | ENSMNEP00000017054 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Nucleotide binding oligomerization domain containing 2. | 0.625 |
DEFB128 | DEFB125 | ENSMNEP00000024003 | ENSMNEP00000035258 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | 0.808 |
DEFB128 | DEFB135 | ENSMNEP00000024003 | ENSMNEP00000013391 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | 0.846 |
DEFB128 | IL10 | ENSMNEP00000024003 | ENSMNEP00000036763 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.474 |
DEFB128 | IL1B | ENSMNEP00000024003 | ENSMNEP00000033521 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.440 |
DEFB128 | NLRC5 | ENSMNEP00000024003 | ENSMNEP00000025631 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | NLR family CARD domain containing 5. | 0.650 |
DEFB128 | NOD2 | ENSMNEP00000024003 | ENSMNEP00000017054 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Nucleotide binding oligomerization domain containing 2. | 0.707 |
DEFB135 | DEFB125 | ENSMNEP00000013391 | ENSMNEP00000035258 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | 0.860 |
DEFB135 | DEFB128 | ENSMNEP00000013391 | ENSMNEP00000024003 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | 0.846 |
DEFB135 | IL4 | ENSMNEP00000013391 | ENSMNEP00000020267 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. | 0.462 |
DEFB135 | NLRC5 | ENSMNEP00000013391 | ENSMNEP00000025631 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | NLR family CARD domain containing 5. | 0.488 |
DEFB135 | NOD2 | ENSMNEP00000013391 | ENSMNEP00000017054 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Nucleotide binding oligomerization domain containing 2. | 0.596 |
GAPDH | GAPDHS | ENSMNEP00000034499 | ENSMNEP00000001461 | Glyceraldehyde-3-phosphate dehydrogenase. | Glyceraldehyde-3-phosphate dehydrogenase. | 0.923 |
GAPDH | IL10 | ENSMNEP00000034499 | ENSMNEP00000036763 | Glyceraldehyde-3-phosphate dehydrogenase. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.564 |
GAPDH | IL1B | ENSMNEP00000034499 | ENSMNEP00000033521 | Glyceraldehyde-3-phosphate dehydrogenase. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.625 |
GAPDH | IL4 | ENSMNEP00000034499 | ENSMNEP00000020267 | Glyceraldehyde-3-phosphate dehydrogenase. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. | 0.465 |
GAPDH | IL6 | ENSMNEP00000034499 | ENSMNEP00000000727 | Glyceraldehyde-3-phosphate dehydrogenase. | Interleukin 6. | 0.673 |