STRINGSTRING
TLR7 TLR7 NLRC5 NLRC5 DEFB128 DEFB128 IL4 IL4 NOD2 NOD2 DEFB135 DEFB135 TLR8 TLR8 GAPDHS GAPDHS IL6 IL6 IL10 IL10 GAPDH GAPDH DEFB125 DEFB125 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
NLRC5NLR family CARD domain containing 5. (1866 aa)
DEFB128Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (93 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
DEFB135Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (76 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (409 aa)
IL6Interleukin 6. (214 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
DEFB125Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (156 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (40%) [HD]