node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD68 | IL1B | ENSMNEP00000031272 | ENSMNEP00000033521 | CD68 molecule. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.654 |
CD68 | IL6 | ENSMNEP00000031272 | ENSMNEP00000000727 | CD68 molecule. | Interleukin 6. | 0.738 |
CD68 | TLR4 | ENSMNEP00000031272 | ENSMNEP00000035110 | CD68 molecule. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.520 |
CXCL1 | IL1B | ENSMNEP00000015830 | ENSMNEP00000033521 | C-X-C motif chemokine. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.725 |
CXCL1 | IL6 | ENSMNEP00000015830 | ENSMNEP00000000727 | C-X-C motif chemokine. | Interleukin 6. | 0.761 |
CXCL1 | TLR4 | ENSMNEP00000015830 | ENSMNEP00000035110 | C-X-C motif chemokine. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.524 |
IL1B | CD68 | ENSMNEP00000033521 | ENSMNEP00000031272 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | CD68 molecule. | 0.654 |
IL1B | CXCL1 | ENSMNEP00000033521 | ENSMNEP00000015830 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | C-X-C motif chemokine. | 0.725 |
IL1B | IL6 | ENSMNEP00000033521 | ENSMNEP00000000727 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Interleukin 6. | 0.932 |
IL1B | PTGS2 | ENSMNEP00000033521 | ENSMNEP00000019419 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Prostaglandin-endoperoxide synthase 2. | 0.807 |
IL1B | TLR4 | ENSMNEP00000033521 | ENSMNEP00000035110 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.778 |
IL6 | CD68 | ENSMNEP00000000727 | ENSMNEP00000031272 | Interleukin 6. | CD68 molecule. | 0.738 |
IL6 | CXCL1 | ENSMNEP00000000727 | ENSMNEP00000015830 | Interleukin 6. | C-X-C motif chemokine. | 0.761 |
IL6 | IL1B | ENSMNEP00000000727 | ENSMNEP00000033521 | Interleukin 6. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.932 |
IL6 | PTGS2 | ENSMNEP00000000727 | ENSMNEP00000019419 | Interleukin 6. | Prostaglandin-endoperoxide synthase 2. | 0.706 |
IL6 | TLR4 | ENSMNEP00000000727 | ENSMNEP00000035110 | Interleukin 6. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.832 |
OXTR | PTGFR | ENSMNEP00000028131 | ENSMNEP00000045017 | Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | Prostaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. | 0.505 |
OXTR | SST | ENSMNEP00000028131 | ENSMNEP00000044922 | Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | Somatostatin. | 0.815 |
PTGFR | OXTR | ENSMNEP00000045017 | ENSMNEP00000028131 | Prostaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. | Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | 0.505 |
PTGFR | PTGS2 | ENSMNEP00000045017 | ENSMNEP00000019419 | Prostaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. | Prostaglandin-endoperoxide synthase 2. | 0.456 |