STRINGSTRING
PDGFRB PDGFRB SLC1A2 SLC1A2 HDAC4 HDAC4 PINK1 PINK1 TET2 TET2 SGK1 SGK1 HDAC3 HDAC3 SRC SRC EGFR EGFR PDGFC PDGFC COMT COMT SLC1A7 SLC1A7 STAT1 STAT1 SNCA SNCA BDNF BDNF IL6 IL6 DCTN1 DCTN1 DNAJC13 DNAJC13 GPX1 GPX1 MAPT MAPT PDGFA PDGFA RHOA RHOA NES NES CYGB CYGB CYCS CYCS SLC1A5 SLC1A5 IL1B IL1B NGB NGB SLC1A3 SLC1A3 VPS35 VPS35 PDGFB PDGFB SLC1A6 SLC1A6 PDGFD PDGFD PDGFRA PDGFRA UCHL1 UCHL1 NOTCH3 NOTCH3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
SLC1A2Amino acid transporter. (574 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1094 aa)
PINK1PTEN induced kinase 1. (581 aa)
TET2Tet methylcytosine dioxygenase 2. (2023 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
SRCTyrosine-protein kinase. (644 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (221 aa)
SLC1A7Amino acid transporter. (619 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
IL6Interleukin 6. (214 aa)
DCTN1CAP-Gly domain-containing protein. (1278 aa)
DNAJC13DnaJ heat shock protein family (Hsp40) member C13. (2243 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
MAPTMicrotubule-associated protein. (776 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
RHOARas homolog family member A. (193 aa)
NESNestin; Belongs to the intermediate filament family. (1549 aa)
CYGBCytoglobin; Belongs to the globin family. (202 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SLC1A5Amino acid transporter. (526 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
NGBNeuroglobin; Belongs to the globin family. (151 aa)
SLC1A3Amino acid transporter. (542 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SLC1A6Amino acid transporter. (564 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (239 aa)
NOTCH3Notch receptor 3. (2275 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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