C-C motif chemokine.

C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.

C-C motif chemokine.

C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.

C-C motif chemokine.

CD163 molecule.

C-C motif chemokine.

T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]

C-C motif chemokine.

CD40 molecule.

C-C motif chemokine.

CD68 molecule.

C-C motif chemokine.

CD80 molecule.

C-C motif chemokine.

CD86 molecule.

C-C motif chemokine.

C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.

C-C motif chemokine.

Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.

C-C motif chemokine.

Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]

C-C motif chemokine.

Interleukin 13.

C-C motif chemokine.

Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.

C-C motif chemokine.

Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.

C-C motif chemokine.

Interleukin 6.

C-C motif chemokine.

Signal transducer and activator of transcription.

C-C motif chemokine.

Toll-like receptor.

C-C motif chemokine.

Toll like receptor 3; Belongs to the Toll-like receptor family.

C-C motif chemokine.

Toll like receptor 4; Belongs to the Toll-like receptor family.

C-C motif chemokine.

Toll like receptor 7; Belongs to the Toll-like receptor family.