STRINGSTRING
TNS2 TNS2 ARHGEF28 ARHGEF28 ARHGAP29 ARHGAP29 ARAF ARAF PRKCE PRKCE DGKB DGKB DEF8 DEF8 RASGRP1 RASGRP1 CHN1 CHN1 DGKE DGKE CHN2 CHN2 DGKK DGKK RASGRP3 RASGRP3 VAV1 VAV1 DGKA DGKA PLEKHM1 PLEKHM1 DGKQ DGKQ RASGRP2 RASGRP2 CIT CIT PRKD1 PRKD1 DGKI DGKI PDZD8 PDZD8 MYO9B MYO9B DGKD DGKD PLEKHM3 PLEKHM3 ROCK2 ROCK2 RACGAP1 RACGAP1 UNC13A UNC13A KMT2C KMT2C KSR2 KSR2 PRKCI PRKCI DGKZ DGKZ GMIP GMIP ARHGAP45 ARHGAP45 PRKCH PRKCH STAC STAC RAF1 RAF1 STAC2 STAC2 PRKCD PRKCD DGKG DGKG PRKD2 PRKD2 UNC13C UNC13C CDC42BPG CDC42BPG DGKH DGKH CDC42BPB CDC42BPB PRKCZ PRKCZ ROCK1 ROCK1 PRKCG PRKCG PRKCA PRKCA AKAP13 AKAP13 UNC13B UNC13B PRKD3 PRKD3 VAV2 VAV2 STAC3 STAC3 RASGRP4 RASGRP4 CDC42BPA CDC42BPA RASSF5 RASSF5 BRAF BRAF PRKCB PRKCB PRKCQ PRKCQ MYO9A MYO9A VAV3 VAV3 KSR1 KSR1 RASSF1 RASSF1 ARHGEF2 ARHGEF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNS2Tensin 2. (1432 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1729 aa)
ARHGAP29Rho GTPase activating protein 29. (1266 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
DGKBDiacylglycerol kinase. (803 aa)
DEF8Differentially expressed in FDCP 8 homolog. (463 aa)
RASGRP1RAS guanyl releasing protein 1. (832 aa)
CHN1Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
DGKEDiacylglycerol kinase. (567 aa)
CHN2Chimaerin; GTPase-activating protein for p21-rac. (468 aa)
DGKKDiacylglycerol kinase. (1265 aa)
RASGRP3RAS guanyl releasing protein 3. (734 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
DGKADiacylglycerol kinase. (735 aa)
PLEKHM1Pleckstrin homology and RUN domain containing M1. (1055 aa)
DGKQDiacylglycerol kinase. (957 aa)
RASGRP2RAS guanyl releasing protein 2. (771 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2069 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (892 aa)
DGKIDiacylglycerol kinase. (1079 aa)
PDZD8PDZ domain containing 8. (1154 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2135 aa)
DGKDDiacylglycerol kinase. (1216 aa)
PLEKHM3Pleckstrin homology domain containing M3. (761 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
RACGAP1Rac GTPase activating protein 1. (632 aa)
UNC13AUnc-13 homolog A. (1717 aa)
KMT2CLysine methyltransferase 2C. (4913 aa)
KSR2Kinase suppressor of ras 2. (950 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
DGKZDiacylglycerol kinase. (1172 aa)
GMIPGEM interacting protein. (974 aa)
ARHGAP45Rho GTPase activating protein 45. (1148 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
STACSH3 and cysteine rich domain. (402 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
STAC2SH3 and cysteine rich domain 2. (411 aa)
PRKCDProtein kinase C. (729 aa)
DGKGDiacylglycerol kinase. (791 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
UNC13CUnc-13 homolog C. (2216 aa)
CDC42BPGCDC42 binding protein kinase gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1559 aa)
DGKHDiacylglycerol kinase. (1220 aa)
CDC42BPBCDC42 binding protein kinase beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1728 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
AKAP13A-kinase anchoring protein 13. (2830 aa)
UNC13BUncharacterized protein. (4339 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (887 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
RASGRP4RAS guanyl releasing protein 4. (673 aa)
CDC42BPANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1732 aa)
RASSF5Ras association domain family member 5. (418 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2555 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
KSR1Kinase suppressor of ras 1. (932 aa)
RASSF1Ras association domain family member 1. (340 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1003 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.