(65 nodes) Metabolism of xenobiotics by cytochrome P450 network (Macaca nemestrina)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MGST2	Microsomal glutathione S-transferase 2. (147 aa)
	ADH6	Alcohol dehydrogenase 6 (class V). (374 aa)
	LOC105497405	Uncharacterized protein. (240 aa)
	AKR7A3	Aldo-keto reductase family 7 member A3. (331 aa)
	LOC105477366	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
	CYP2E1	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (494 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa)
	ENSMNEP00000027418	Uncharacterized protein; Belongs to the GST superfamily. (202 aa)
	LOC105498674	Uncharacterized protein; Belongs to the cytochrome P450 family. (537 aa)
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
	LOC105464352	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	GSTA3	Glutathione S-transferase alpha 3. (222 aa)
	CBR1	Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (290 aa)
	UGT2A3	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (522 aa)
	LOC105477362	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	SULT2A1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	LOC105479916	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	HSD11B1	Hydroxysteroid 11-beta dehydrogenase 1. (292 aa)
	ADH4	Alcohol dehydrogenase 4 (class II), pi polypeptide. (416 aa)
	CYP2F1	Cytochrome P450 family 2 subfamily F member 1. (466 aa)
	GSTO2	Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
	ENSMNEP00000017251	Uncharacterized protein. (311 aa)
	LOC105477045	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
	GSTO1	Uncharacterized protein; Belongs to the GST superfamily. (252 aa)
	LOC105490779	Aldo_ket_red domain-containing protein. (323 aa)
	ADH5	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
	UGT1A1	UDP glucuronosyltransferase family 1 member A1; Belongs to the UDP-glycosyltransferase family. (570 aa)
	LOC105495313	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	ENSMNEP00000035800	Uncharacterized protein; Belongs to the cytochrome P450 family. (448 aa)
	MGST3	Microsomal glutathione S-transferase 3. (166 aa)
	EPHX1	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (477 aa)
	LOC105464350	Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
	ALDH3B2	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family. (385 aa)
	MGST1	Microsomal glutathione S-transferase 1. (155 aa)
	DHDH	Dihydrodiol dehydrogenase. (216 aa)
	CYP2B6	Cytochrome P450 family 2 subfamily B member 6; Belongs to the cytochrome P450 family. (491 aa)
	GSTK1	Glutathione S-transferase kappa. (226 aa)
	ENSMNEP00000042658	annotation not available (67 aa)
	GSTP1	Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
	LOC105490780	Aldo-keto reductase family 1 member C1. (323 aa)
	LOC105463617	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	LOC105477363	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	ENSMNEP00000044246	Uncharacterized protein. (426 aa)
	GSTM3	Glutathione S-transferase. (225 aa)
	ALDH3B1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (534 aa)
	LOC105483116	Aldo_ket_red domain-containing protein. (359 aa)
	HSD11B1L	Hydroxysteroid 11-beta dehydrogenase 1 like. (300 aa)
	ENSMNEP00000000907	Uncharacterized protein. (241 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
	ENSMNEP00000019397	Uncharacterized protein. (279 aa)
	AKR7L	Aldo-keto reductase family 7 like (gene/pseudogene). (331 aa)
	UGT2A1	UDP glucuronosyltransferase family 2 member A1 complex locus; Belongs to the UDP-glycosyltransferase family. (693 aa)
	ENSMNEP00000021019	Glutathione S-transferase. (213 aa)
	ADH7	Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide. (394 aa)
	LOC105497406	GST N-terminal domain-containing protein. (67 aa)
	C2orf69	Chromosome 2 open reading frame 69. (386 aa)
	CYP3A5	Cytochrome P450 family 3 subfamily A member 5. (503 aa)
	ENSMNEP00000008644	Uncharacterized protein. (322 aa)
	ALDH3A1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (480 aa)
	GSTM4	Glutathione S-transferase mu 4; Belongs to the GST superfamily. (218 aa)
	GSTT2B	Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
	ADH1A	Alcohol dehydrogenase 1A (class I), alpha polypeptide. (374 aa)
	GSTA4	Glutathione S-transferase alpha 4. (222 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH1A	ADH7	ENSMNEP00000005435	ENSMNEP00000018247	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide.	0.546
ADH1A	ALDH3A1	ENSMNEP00000005435	ENSMNEP00000007851	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.999
ADH1A	ALDH3B1	ENSMNEP00000005435	ENSMNEP00000044622	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.999
ADH1A	ALDH3B2	ENSMNEP00000005435	ENSMNEP00000038675	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family.	0.908
ADH1A	CYP2E1	ENSMNEP00000005435	ENSMNEP00000025973	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	0.999
ADH1A	ENSMNEP00000000907	ENSMNEP00000005435	ENSMNEP00000000907	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Uncharacterized protein.	0.545
ADH1A	ENSMNEP00000021019	ENSMNEP00000005435	ENSMNEP00000021019	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase.	0.414
ADH1A	ENSMNEP00000042658	ENSMNEP00000005435	ENSMNEP00000042658	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	annotation not available	0.521
ADH1A	GSTA3	ENSMNEP00000005435	ENSMNEP00000028936	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase alpha 3.	0.751
ADH1A	GSTA4	ENSMNEP00000005435	ENSMNEP00000003867	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase alpha 4.	0.752
ADH1A	GSTK1	ENSMNEP00000005435	ENSMNEP00000042555	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase kappa.	0.758
ADH1A	GSTM3	ENSMNEP00000005435	ENSMNEP00000044309	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase.	0.862
ADH1A	GSTM4	ENSMNEP00000005435	ENSMNEP00000007721	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase mu 4; Belongs to the GST superfamily.	0.835
ADH1A	GSTO1	ENSMNEP00000005435	ENSMNEP00000014207	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Uncharacterized protein; Belongs to the GST superfamily.	0.864
ADH1A	GSTO2	ENSMNEP00000005435	ENSMNEP00000017342	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase omega 2; Belongs to the GST superfamily.	0.864
ADH1A	GSTP1	ENSMNEP00000005435	ENSMNEP00000043232	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase pi 1; Belongs to the GST superfamily.	0.877
ADH1A	GSTT2B	ENSMNEP00000005435	ENSMNEP00000007488	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Uncharacterized protein; Belongs to the GST superfamily.	0.760
ADH1A	HPGDS	ENSMNEP00000005435	ENSMNEP00000019062	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	0.874
ADH1A	LOC105463617	ENSMNEP00000005435	ENSMNEP00000044184	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.748
ADH1A	LOC105477362	ENSMNEP00000005435	ENSMNEP00000030637	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.860