STRINGSTRING
PUS3 PUS3 UPB1 UPB1 ITPA ITPA ENSMNEP00000017255 ENSMNEP00000017255 GSTO2 GSTO2 SPSB1 SPSB1 CES2 CES2 DPYS DPYS ENSMNEP00000019144 ENSMNEP00000019144 FAM78A FAM78A ENSMNEP00000019397 ENSMNEP00000019397 TK2 TK2 SPSB2 SPSB2 UGT2A1 UGT2A1 GDAP1L1 GDAP1L1 ENSMNEP00000021019 ENSMNEP00000021019 CES1 CES1 LOC105497406 LOC105497406 CDA CDA FBXL2 FBXL2 RRM1 RRM1 HPRT1 HPRT1 ENSMNEP00000023472 ENSMNEP00000023472 MGST2 MGST2 LOC105497405 LOC105497405 IMPDH2 IMPDH2 LOC105477366 LOC105477366 CYP2E1 CYP2E1 UCK1 UCK1 UMPS UMPS ENSMNEP00000027418 ENSMNEP00000027418 NME5 NME5 ENSMNEP00000015921 ENSMNEP00000015921 ENSMNEP00000027461 ENSMNEP00000027461 CMPK1 CMPK1 TK1 TK1 NAT1 NAT1 ENSMNEP00000028510 ENSMNEP00000028510 GSTA3 GSTA3 PUSL1 PUSL1 PFDN5 PFDN5 UGT2A3 UGT2A3 LOC105477362 LOC105477362 ENSMNEP00000030853 ENSMNEP00000030853 ENSMNEP00000032397 ENSMNEP00000032397 ENSMNEP00000033027 ENSMNEP00000033027 UCK2 UCK2 UPP2 UPP2 FAM78B FAM78B NME6 NME6 PUS1 PUS1 FBXO45 FBXO45 ENSMNEP00000000907 ENSMNEP00000000907 PRTFDC1 PRTFDC1 ENSMNEP00000001503 ENSMNEP00000001503 ENSMNEP00000002012 ENSMNEP00000002012 ENSMNEP00000002133 ENSMNEP00000002133 ENSMNEP00000002186 ENSMNEP00000002186 ENSMNEP00000002532 ENSMNEP00000002532 TPMT TPMT NME3 NME3 GSTA4 GSTA4 UCKL1 UCKL1 ENSMNEP00000005163 ENSMNEP00000005163 SLC12A1 SLC12A1 LOC105494112 LOC105494112 ENSMNEP00000006481 ENSMNEP00000006481 RRM2 RRM2 GSTT2B GSTT2B GSTM4 GSTM4 SPSB4 SPSB4 ENSMNEP00000008691 ENSMNEP00000008691 DPYD DPYD UGT1A1 UGT1A1 GMPS GMPS GDAP1 GDAP1 ENSMNEP00000011489 ENSMNEP00000011489 XDH XDH MPO MPO IMPDH1 IMPDH1 IMPDH IMPDH GSTO1 GSTO1 UPP1 UPP1 NME4 NME4 NME7 NME7 NME1-NME2 NME1-NME2 MRPS34 MRPS34 MGST3 MGST3 DUT DUT FBXL20 FBXL20 ENSMNEP00000038452 ENSMNEP00000038452 MGST1 MGST1 DALRD3 DALRD3 SPSB3 SPSB3 ENSMNEP00000042658 ENSMNEP00000042658 GSTP1 GSTP1 LOC105463617 LOC105463617 LOC105477363 LOC105477363 GSTM3 GSTM3 FBXO41 FBXO41 TYMP TYMP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PUS3Pseudouridine synthase 3. (480 aa)
UPB1Beta-ureidopropionase 1. (386 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (208 aa)
ENSMNEP00000017255Uncharacterized protein. (152 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
SPSB1SplA/ryanodine receptor domain and SOCS box containing 1. (273 aa)
CES2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (645 aa)
DPYSDihydropyrimidinase. (519 aa)
ENSMNEP00000019144IMPDH domain-containing protein. (465 aa)
FAM78AFamily with sequence similarity 78 member A. (283 aa)
ENSMNEP00000019397Uncharacterized protein. (279 aa)
TK2Thymidine kinase 2. (281 aa)
SPSB2SplA/ryanodine receptor domain and SOCS box containing 2. (257 aa)
UGT2A1UDP glucuronosyltransferase family 2 member A1 complex locus; Belongs to the UDP-glycosyltransferase family. (693 aa)
GDAP1L1Ganglioside induced differentiation associated protein 1 like 1. (367 aa)
ENSMNEP00000021019Glutathione S-transferase. (213 aa)
CES1Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa)
LOC105497406GST N-terminal domain-containing protein. (67 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
FBXL2F-box and leucine rich repeat protein 2. (423 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (220 aa)
ENSMNEP00000023472Uncharacterized protein. (66 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
LOC105497405Uncharacterized protein. (240 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
LOC105477366UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
CYP2E1Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (494 aa)
UCK1Uridine-cytidine kinase; Belongs to the uridine kinase family. (277 aa)
UMPSUridine monophosphate synthetase. (480 aa)
ENSMNEP00000027418Uncharacterized protein; Belongs to the GST superfamily. (202 aa)
NME5NME/NM23 family member 5; Belongs to the NDK family. (212 aa)
ENSMNEP00000015921Uncharacterized protein. (554 aa)
ENSMNEP00000027461Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (337 aa)
CMPK1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa)
TK1Thymidine kinase. (261 aa)
NAT1N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family. (352 aa)
ENSMNEP00000028510Uncharacterized protein; Belongs to the IMPDH/GMPR family. (458 aa)
GSTA3Glutathione S-transferase alpha 3. (222 aa)
PUSL1tRNA pseudouridine synthase. (302 aa)
PFDN5Uncharacterized protein. (160 aa)
UGT2A3UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
LOC105477362UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
ENSMNEP00000030853Uncharacterized protein. (642 aa)
ENSMNEP00000032397Uncharacterized protein. (298 aa)
ENSMNEP00000033027CBS domain-containing protein. (458 aa)
UCK2Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
UPP2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (363 aa)
FAM78BFamily with sequence similarity 78 member B. (261 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
PUS1Pseudouridine synthase 1. (427 aa)
FBXO45F-box protein 45. (271 aa)
ENSMNEP00000000907Uncharacterized protein. (241 aa)
PRTFDC1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (220 aa)
ENSMNEP00000001503Uncharacterized protein. (73 aa)
ENSMNEP00000002012dUTPase domain-containing protein. (159 aa)
ENSMNEP00000002133Uncharacterized protein. (656 aa)
ENSMNEP00000002186Uncharacterized protein. (402 aa)
ENSMNEP00000002532Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (499 aa)
TPMTThiopurine S-methyltransferase. (244 aa)
NME3Nucleoside diphosphate kinase. (169 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
UCKL1Uridine-cytidine kinase; Belongs to the uridine kinase family. (555 aa)
ENSMNEP00000005163dUTPase domain-containing protein. (66 aa)
SLC12A1Solute carrier family 12 member 1. (1099 aa)
LOC105494112Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (570 aa)
ENSMNEP00000006481NDK domain-containing protein; Belongs to the NDK family. (179 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (439 aa)
GSTT2BUncharacterized protein; Belongs to the GST superfamily. (244 aa)
GSTM4Glutathione S-transferase mu 4; Belongs to the GST superfamily. (218 aa)
SPSB4SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
ENSMNEP00000008691dUTPase domain-containing protein. (136 aa)
DPYDDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa)
UGT1A1UDP glucuronosyltransferase family 1 member A1; Belongs to the UDP-glycosyltransferase family. (570 aa)
GMPSGuanine monophosphate synthase. (661 aa)
GDAP1Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (358 aa)
ENSMNEP00000011489Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
XDHXanthine dehydrogenase. (1333 aa)
MPOMyeloperoxidase. (797 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (627 aa)
IMPDHInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (634 aa)
GSTO1Uncharacterized protein; Belongs to the GST superfamily. (252 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (314 aa)
NME4Nucleoside diphosphate kinase. (195 aa)
NME7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (387 aa)
NME1-NME2Nucleoside diphosphate kinase. (292 aa)
MRPS34Mitochondrial ribosomal protein S34. (218 aa)
MGST3Microsomal glutathione S-transferase 3. (166 aa)
DUTdUTPase domain-containing protein. (252 aa)
FBXL20F-box and leucine rich repeat protein 20. (438 aa)
ENSMNEP00000038452Uncharacterized protein. (396 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
DALRD3DALR anticodon binding domain containing 3. (543 aa)
SPSB3SplA/ryanodine receptor domain and SOCS box containing 3. (355 aa)
ENSMNEP00000042658annotation not available (67 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
LOC105463617UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
LOC105477363UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
GSTM3Glutathione S-transferase. (225 aa)
FBXO41F-box protein 41. (878 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (482 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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