STRINGSTRING
PIK3R1 PIK3R1 AXL AXL PIK3CB PIK3CB IL6 IL6 ERAS ERAS ENSMNEP00000001215 ENSMNEP00000001215 IGF1 IGF1 ENSMNEP00000001669 ENSMNEP00000001669 JAK1 JAK1 LOC105495040 LOC105495040 TPTE2 TPTE2 BCL2L1 BCL2L1 EIF4E EIF4E PLCG2 PLCG2 PDGFC PDGFC EGFR EGFR BRAF BRAF PRKCB PRKCB ENSMNEP00000005777 ENSMNEP00000005777 GSK3B GSK3B SRC SRC MAP2K1 MAP2K1 SOS2 SOS2 PTEN PTEN PIK3R2 PIK3R2 MTOR MTOR NRG2 NRG2 NF1 NF1 ENSMNEP00000011545 ENSMNEP00000011545 ERBB3 ERBB3 MAPK1 MAPK1 JAK2 JAK2 EIF4E1B EIF4E1B MAPK3 MAPK3 ENSMNEP00000016378 ENSMNEP00000016378 RPS6KB2 RPS6KB2 GAB1 GAB1 ARAF ARAF EIF4EBP1 EIF4EBP1 STAT3 STAT3 PDGFRB PDGFRB CEP152 CEP152 ENSMNEP00000046073 ENSMNEP00000046073 PPP1R14B PPP1R14B FGF2 FGF2 ERBB2 ERBB2 CSDE1 CSDE1 KRAS KRAS RPS6KB1 RPS6KB1 NRAS NRAS BAD BAD IL6R IL6R TBCA TBCA MAP2K2 MAP2K2 SOS1 SOS1 BCL2L11 BCL2L11 FGFR3 FGFR3 KDR KDR PLCG1 PLCG1 PDGFA PDGFA LOC105487991 LOC105487991 AKT3 AKT3 PIK3R3 PIK3R3 ENSMNEP00000036225 ENSMNEP00000036225 VEGFA VEGFA FGFR2 FGFR2 RAF1 RAF1 SHC2 SHC2 SHC1 SHC1 HGF HGF FOXO3 FOXO3 ENSMNEP00000032306 ENSMNEP00000032306 HRAS HRAS NRG1 NRG1 PIK3CD PIK3CD EGF EGF ENSMNEP00000019824 ENSMNEP00000019824 PIK3CA PIK3CA PDGFRA PDGFRA BAX BAX BCL2 BCL2 SHC4 SHC4 PDGFD PDGFD SHC3 SHC3 AKT1 AKT1 GAS6 GAS6 GRB2 GRB2 TGFA TGFA ENSMNEP00000027902 ENSMNEP00000027902 PRKCA PRKCA PRKCG PRKCG AKT2 AKT2 PDGFB PDGFB EIF4E2 EIF4E2 IGF1R IGF1R MET MET
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
IL6Interleukin 6. (214 aa)
ERASES cell expressed Ras. (233 aa)
ENSMNEP00000001215Uncharacterized protein. (87 aa)
IGF1Insulin like growth factor 1. (208 aa)
ENSMNEP00000001669Uncharacterized protein. (77 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
LOC105495040Tubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
TPTE2Uncharacterized protein. (558 aa)
BCL2L1BCL2 like 1. (233 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ENSMNEP0000000577740S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
SRCTyrosine-protein kinase. (644 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PIK3R2Uncharacterized protein. (668 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
NRG2Neuregulin 2. (632 aa)
NF1Neurofibromin 1. (2839 aa)
ENSMNEP00000011545Uncharacterized protein. (81 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CEP152Centrosomal protein 152. (1703 aa)
ENSMNEP00000046073Uncharacterized protein. (253 aa)
PPP1R14BUncharacterized protein. (208 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (357 aa)
ERBB2Receptor protein-tyrosine kinase. (1390 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (167 aa)
IL6RInterleukin 6 receptor. (467 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
LOC10548799140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (244 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
ENSMNEP00000036225SRCR domain-containing protein; Belongs to the eukaryotic initiation factor 4E family. (111 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (452 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SHC2Uncharacterized protein. (572 aa)
SHC1SHC adaptor protein 1. (584 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
FOXO3Forkhead box O3. (716 aa)
ENSMNEP00000032306Uncharacterized protein. (202 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NRG1Neuregulin 1. (645 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
ENSMNEP00000019824Uncharacterized protein. (194 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SHC4SHC adaptor protein 4. (630 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
SHC3SHC adaptor protein 3. (598 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GAS6Growth arrest specific 6. (683 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
TGFATransforming growth factor alpha. (166 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1403 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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