STRINGSTRING
MDM2 MDM2 PPP1R14B PPP1R14B ERBB2 ERBB2 CSDE1 CSDE1 MAPK14 MAPK14 ADCY3 ADCY3 KRAS KRAS RPS6KB1 RPS6KB1 ADCY2 ADCY2 CDKN2A CDKN2A NRAS NRAS BAD BAD JAG2 JAG2 MAP2K2 MAP2K2 SOS1 SOS1 ADCY5 ADCY5 MED1 MED1 E2F3 E2F3 ADCY6 ADCY6 PRKACA PRKACA MAPK10 MAPK10 MAPK12 MAPK12 AKT3 AKT3 PIK3R3 PIK3R3 ADCY4 ADCY4 LOC105464350 LOC105464350 MAPK9 MAPK9 E2F2 E2F2 SP1 SP1 CCND1 CCND1 MAPK13 MAPK13 RAF1 RAF1 SHC2 SHC2 SHC1 SHC1 NOTCH4 NOTCH4 ADCY8 ADCY8 BIK BIK HRAS HRAS PRKACB PRKACB DLL4 DLL4 PIK3CD PIK3CD TP53 TP53 PIK3R1 PIK3R1 IGF1R IGF1R JAG1 JAG1 AKT2 AKT2 ENSMNEP00000027902 ENSMNEP00000027902 LOC105464352 LOC105464352 GPER1 GPER1 GRB2 GRB2 AKT1 AKT1 SHC3 SHC3 PTK2 PTK2 SHC4 SHC4 BCL2 BCL2 BAX BAX NCOA3 NCOA3 PTRHD1 PTRHD1 MMP9 MMP9 NCOR1 NCOR1 GNAS GNAS NOTCH3 NOTCH3 ABCB11 ABCB11 PIK3CA PIK3CA DLL3 DLL3 ENSMNEP00000019824 ENSMNEP00000019824 CEP152 CEP152 ESR1 ESR1 ESR2 ESR2 ARAF ARAF RPS6KB2 RPS6KB2 ENSMNEP00000016378 ENSMNEP00000016378 CDK4 CDK4 MAPK3 MAPK3 MMP2 MMP2 CDKN2C CDKN2C CDKN1B CDKN1B FOS FOS CARM1 CARM1 MAPK8 MAPK8 EYS EYS NOTCH1 NOTCH1 RB1 RB1 MAPK11 MAPK11 MAPK1 MAPK1 ENSMNEP00000011545 ENSMNEP00000011545 HBEGF HBEGF MTOR MTOR ADCY1 ADCY1 NOTCH2 NOTCH2 ADCY7 ADCY7 PIK3R2 PIK3R2 SOS2 SOS2 DLL1 DLL1 MAP2K1 MAP2K1 SRC SRC E2F1 E2F1 BRAF BRAF EGFR EGFR CCDC170 CCDC170 GPSM3 GPSM3 ADCY9 ADCY9 CDKN1A CDKN1A IGF1 IGF1 ERAS ERAS LOC105470579 LOC105470579 PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
PPP1R14BUncharacterized protein. (208 aa)
ERBB2Receptor protein-tyrosine kinase. (1390 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (160 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (167 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1238 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1490 aa)
E2F3E2F transcription factor 3. (465 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1214 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
LOC105464350Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
E2F2E2F transcription factor 2. (439 aa)
SP1Sp1 transcription factor. (786 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SHC2Uncharacterized protein. (572 aa)
SHC1SHC adaptor protein 1. (584 aa)
NOTCH4Notch receptor 4. (2001 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
BIKBCL2 interacting killer. (160 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
LOC105464352Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SHC3SHC adaptor protein 3. (598 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1054 aa)
SHC4SHC adaptor protein 4. (630 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
NCOA3Nuclear receptor coactivator. (1421 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
MMP9Matrix metallopeptidase 9. (694 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
GNASGNAS complex locus. (1007 aa)
NOTCH3Notch receptor 3. (2275 aa)
ABCB11ATP binding cassette subfamily B member 11. (1323 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DLL3Delta like canonical Notch ligand 3. (587 aa)
ENSMNEP00000019824Uncharacterized protein. (194 aa)
CEP152Centrosomal protein 152. (1703 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ESR2Estrogen receptor 2. (530 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (260 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (611 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
EYSEyes shut homolog. (3165 aa)
NOTCH1Notch receptor 1. (2556 aa)
RB1RB transcriptional corepressor 1. (928 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSMNEP00000011545Uncharacterized protein. (81 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1088 aa)
NOTCH2Notch receptor 2. (2471 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
PIK3R2Uncharacterized protein. (668 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
SRCTyrosine-protein kinase. (644 aa)
E2F1E2F transcription factor 1. (437 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CCDC170Coiled-coil domain containing 170. (763 aa)
GPSM3G protein signaling modulator 3. (160 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
IGF1Insulin like growth factor 1. (208 aa)
ERASES cell expressed Ras. (233 aa)
LOC105470579Uncharacterized protein. (245 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.