STRINGSTRING
RNASEH2B RNASEH2B RFC5 RFC5 SASS6 SASS6 MCM6 MCM6 CPNE8 CPNE8 CPNE3 CPNE3 CPNE7 CPNE7 ENSMNEP00000010901 ENSMNEP00000010901 ENSMNEP00000010543 ENSMNEP00000010543 ENSMNEP00000010064 ENSMNEP00000010064 CABP5 CABP5 TM4SF19 TM4SF19 CPNE4 CPNE4 DNA2 DNA2 POLE2 POLE2 FEN1 FEN1 POLE4 POLE4 POLD4 POLD4 ENSMNEP00000001946 ENSMNEP00000001946 ENSMNEP00000001356 ENSMNEP00000001356 ENSMNEP00000001312 ENSMNEP00000001312 MEIOB MEIOB TOR3A TOR3A PRKRIP1 PRKRIP1 LIG1 LIG1 ENSMNEP00000014131 ENSMNEP00000014131 ENSMNEP00000015014 ENSMNEP00000015014 STN1 STN1 PCNA PCNA RPA2 RPA2 POLA1 POLA1 PPIL3 PPIL3 FAM162B FAM162B CPNE9 CPNE9 WRNIP1 WRNIP1 MCMDC2 MCMDC2 PRIM1 PRIM1 RFC1 RFC1 POLD2 POLD2 RFC3 RFC3 RNASEH2A RNASEH2A CPNE5 CPNE5 PARP9 PARP9 C16orf70 C16orf70 ENSMNEP00000021343 ENSMNEP00000021343 MCM2 MCM2 RFC2 RFC2 MACROD1 MACROD1 SSBP1 SSBP1 ENSMNEP00000023094 ENSMNEP00000023094 POLE POLE CPNE6 CPNE6 MCM3 MCM3 MCM9 MCM9 ENSMNEP00000024470 ENSMNEP00000024470 RAD17 RAD17 PARP14 PARP14 YJU2 YJU2 ENSMNEP00000026028 ENSMNEP00000026028 FAM162A FAM162A TOR1B TOR1B EXOC8 EXOC8 CPNE2 CPNE2 GTF3C6 GTF3C6 RFC4 RFC4 POLD1 POLD1 PARP15 PARP15 TOR2A TOR2A RNASEH1 RNASEH1 RNASEH2C RNASEH2C TOR1A TOR1A ATAD5 ATAD5 GEN1 GEN1 GDAP2 GDAP2 MCM7 MCM7 MCM5 MCM5 CHRAC1 CHRAC1 MCM4 MCM4 POLE3 POLE3 POLD3 POLD3 ENSMNEP00000042122 ENSMNEP00000042122 RPA3 RPA3 ENSMNEP00000045253 ENSMNEP00000045253 ENSMNEP00000045772 ENSMNEP00000045772
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNASEH2BUncharacterized protein. (359 aa)
RFC5Replication factor C subunit 5. (340 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
MCM6DNA helicase; Belongs to the MCM family. (785 aa)
CPNE8Copine 8. (564 aa)
CPNE3Copine 3. (537 aa)
CPNE7Copine 7. (592 aa)
ENSMNEP00000010901Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (547 aa)
ENSMNEP00000010543Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (277 aa)
ENSMNEP00000010064TFIIIC_sub6 domain-containing protein. (182 aa)
CABP5Calcium binding protein 5. (173 aa)
TM4SF19Uncharacterized protein. (209 aa)
CPNE4Copine 4. (575 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
POLD4Uncharacterized protein. (107 aa)
ENSMNEP00000001946Uncharacterized protein. (83 aa)
ENSMNEP00000001356Uncharacterized protein. (139 aa)
ENSMNEP00000001312Uncharacterized protein. (139 aa)
MEIOBMeiosis specific with OB-fold. (476 aa)
TOR3ATorsin family 3 member A. (402 aa)
PRKRIP1PRKR interacting protein 1. (181 aa)
LIG1DNA ligase. (919 aa)
ENSMNEP00000014131Uncharacterized protein. (72 aa)
ENSMNEP00000015014Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (596 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RPA2Replication protein A2. (270 aa)
POLA1DNA polymerase. (1478 aa)
PPIL3Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (177 aa)
FAM162BFamily with sequence similarity 162 member B. (125 aa)
CPNE9Copine family member 9. (553 aa)
WRNIP1WRN helicase interacting protein 1. (665 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (374 aa)
RFC1Replication factor C subunit 1. (1148 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
RFC3Replication factor C subunit 3. (356 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa)
CPNE5Copine 5. (593 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (818 aa)
C16orf70Chromosome 16 open reading frame 70. (422 aa)
ENSMNEP00000021343Uncharacterized protein. (92 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
RFC2Replication factor C subunit 2. (340 aa)
MACROD1Mono-ADP ribosylhydrolase 1. (334 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
ENSMNEP00000023094Uncharacterized protein. (159 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2263 aa)
CPNE6Copine 6. (560 aa)
MCM3DNA helicase; Belongs to the MCM family. (853 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
ENSMNEP00000024470RPA_C domain-containing protein. (247 aa)
RAD17RAD17 checkpoint clamp loader component. (681 aa)
PARP14Poly [ADP-ribose] polymerase. (1800 aa)
YJU2YJU2 splicing factor homolog. (323 aa)
ENSMNEP00000026028Uncharacterized protein. (77 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
TOR1BTorsin. (336 aa)
EXOC8Exocyst complex component 8. (725 aa)
CPNE2Copine 2. (548 aa)
GTF3C6TFIIIC_sub6 domain-containing protein. (213 aa)
RFC4Replication factor C subunit 4. (363 aa)
POLD1DNA polymerase. (1126 aa)
PARP15Poly [ADP-ribose] polymerase. (660 aa)
TOR2ATorsin. (321 aa)
RNASEH1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa)
RNASEH2CRibonuclease H2 subunit C. (164 aa)
TOR1ATorsin. (327 aa)
ATAD5ATPase family AAA domain containing 5. (1833 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (918 aa)
GDAP2Ganglioside induced differentiation associated protein 2. (497 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
MCM5DNA helicase; Belongs to the MCM family. (742 aa)
CHRAC1Chromatin accessibility complex subunit 1. (131 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
POLD3Uncharacterized protein. (466 aa)
ENSMNEP00000042122Uncharacterized protein. (222 aa)
RPA3Replication protein A3. (121 aa)
ENSMNEP00000045253Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (234 aa)
ENSMNEP00000045772DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (578 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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