STRINGSTRING
ENSMNEP00000002071 ENSMNEP00000002071 CDKN1A CDKN1A LOC105495040 LOC105495040 VHL VHL EIF4E EIF4E PLCG2 PLCG2 INSR INSR EGFR EGFR NOS3 NOS3 PFKFB3 PFKFB3 PRKCB PRKCB ENSMNEP00000005777 ENSMNEP00000005777 ENSMNEP00000000054 ENSMNEP00000000054 PIK3CB PIK3CB IL6 IL6 MKNK2 MKNK2 IGF1 IGF1 EGLN2 EGLN2 CAMK2D CAMK2D ENSMNEP00000045959 ENSMNEP00000045959 ERBB2 ERBB2 ENO1 ENO1 RPS6KB1 RPS6KB1 IFNG IFNG PDK1 PDK1 IL6R IL6R ENSMNEP00000043560 ENSMNEP00000043560 CAMK2A CAMK2A TBCA TBCA MAP2K2 MAP2K2 ARNT ARNT ENSMNEP00000041455 ENSMNEP00000041455 HIF1A HIF1A CREBBP CREBBP PDHA1 PDHA1 EP300 EP300 ENSMNEP00000040621 ENSMNEP00000040621 TF TF PLCG1 PLCG1 ENSMNEP00000039400 ENSMNEP00000039400 IFNGR1 IFNGR1 LOC105487991 LOC105487991 AKT3 AKT3 ENSMNEP00000038918 ENSMNEP00000038918 PIK3R3 PIK3R3 CAMK2G CAMK2G ANGPT1 ANGPT1 HKDC1 HKDC1 ENSMNEP00000036225 ENSMNEP00000036225 LDHAL6A LDHAL6A VEGFA VEGFA EGLN1 EGLN1 TLR4 TLR4 GAPDH GAPDH EPO EPO CUL2 CUL2 ENSMNEP00000032783 ENSMNEP00000032783 TFRC TFRC ENSMNEP00000032306 ENSMNEP00000032306 ARSI ARSI CAMK2B CAMK2B ANGPT4 ANGPT4 PFKP PFKP PIK3CD PIK3CD PIK3R1 PIK3R1 IGF1R IGF1R ENO4 ENO4 EIF4E2 EIF4E2 RBX1 RBX1 PGK2 PGK2 AKT2 AKT2 PRKCG PRKCG PRKCA PRKCA PDHA2 PDHA2 RELA RELA LTF LTF MKNK1 MKNK1 ENSMNEP00000027902 ENSMNEP00000027902 ENSMNEP00000027382 ENSMNEP00000027382 NPPA NPPA PFKM PFKM ALDOA ALDOA AKT1 AKT1 INS INS TEK TEK HK2 HK2 PDHB PDHB ENSMNEP00000025129 ENSMNEP00000025129 ELOB ELOB BCL2 BCL2 SLC2A1 SLC2A1 ALDOC ALDOC ENSMNEP00000022407 ENSMNEP00000022407 ENO2 ENO2 IFNGR2 IFNGR2 EGLN3 EGLN3 ENSMNEP00000021101 ENSMNEP00000021101 PGK1 PGK1 ENSMNEP00000020786 ENSMNEP00000020786 TIMP1 TIMP1 PIK3CA PIK3CA ZAN ZAN LDHC LDHC ENSMNEP00000019879 ENSMNEP00000019879 EGF EGF STAT3 STAT3 ENSMNEP00000018960 ENSMNEP00000018960 ENSMNEP00000018849 ENSMNEP00000018849 ENSMNEP00000018541 ENSMNEP00000018541 ENSMNEP00000018330 ENSMNEP00000018330 ANGPT2 ANGPT2 ELOC ELOC ENSMNEP00000017998 ENSMNEP00000017998 LDHB LDHB EIF4EBP1 EIF4EBP1 PFKL PFKL ALDOB ALDOB RPS6KB2 RPS6KB2 ENO3 ENO3 FLT1 FLT1 ENSMNEP00000016253 ENSMNEP00000016253 ENSMNEP00000016245 ENSMNEP00000016245 MAPK3 MAPK3 CDKN1B CDKN1B EIF4E1B EIF4E1B HMOX1 HMOX1 NOS2 NOS2 HK3 HK3 LTBR LTBR FCGBP FCGBP MAPK1 MAPK1 LOC105496960 LOC105496960 NFKB1 NFKB1 MTOR MTOR ENSMNEP00000008345 ENSMNEP00000008345 EDN1 EDN1 PIK3R2 PIK3R2 HK1 HK1 ENSMNEP00000007014 ENSMNEP00000007014 SERPINE1 SERPINE1 MAP2K1 MAP2K1 CYBB CYBB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMNEP00000002071PFK domain-containing protein. (205 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
LOC105495040Tubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
INSRTyrosine-protein kinase receptor. (1306 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (568 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ENSMNEP0000000577740S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ENSMNEP00000000054Ldh_1_C domain-containing protein. (311 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
IL6Interleukin 6. (214 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
IGF1Insulin like growth factor 1. (208 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
ENSMNEP00000045959Uncharacterized protein. (66 aa)
ERBB2Receptor protein-tyrosine kinase. (1390 aa)
ENO1Enolase 1. (413 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
IL6RInterleukin 6 receptor. (467 aa)
ENSMNEP00000043560E1_dh domain-containing protein. (371 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (714 aa)
ENSMNEP00000041455Phosphoglycerate kinase. (393 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
CREBBPCREB binding protein. (2442 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (428 aa)
EP300E1A binding protein p300. (2397 aa)
ENSMNEP00000040621Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (314 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
ENSMNEP00000039400Ubiquitin-like domain-containing protein. (104 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
LOC10548799140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (244 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSMNEP00000038918L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (307 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
ANGPT1Angiopoietin 1. (498 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
ENSMNEP00000036225SRCR domain-containing protein; Belongs to the eukaryotic initiation factor 4E family. (111 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (452 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
CUL2Cullin 2; Belongs to the cullin family. (764 aa)
ENSMNEP00000032783L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
TFRCTransferrin receptor. (764 aa)
ENSMNEP00000032306Uncharacterized protein. (202 aa)
ARSIArylsulfatase family member I. (569 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
ANGPT4Angiopoietin 4. (503 aa)
PFKP6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (773 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ENO4Enolase 4. (627 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
RBX1RING-type domain-containing protein. (108 aa)
PGK2Phosphoglycerate kinase. (417 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
LTFLactotransferrin; Belongs to the transferrin family. (747 aa)
MKNK1MAPK interacting serine/threonine kinase 1. (520 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
ENSMNEP00000027382L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (324 aa)
NPPANatriuretic peptide A. (153 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
ALDOAUncharacterized protein. (139 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
HK2Hexokinase 2. (917 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
ENSMNEP00000025129Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa)
ELOBElongin B. (167 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (370 aa)
ENSMNEP00000022407Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (308 aa)
ENO2Enolase 2. (434 aa)
IFNGR2Interferon gamma receptor 2. (312 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
ENSMNEP00000021101Zf-rbx1 domain-containing protein. (93 aa)
PGK1Phosphoglycerate kinase. (417 aa)
ENSMNEP00000020786Uncharacterized protein; Belongs to the LDH/MDH superfamily. (330 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ZANZonadhesin (gene/pseudogene). (2561 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
ENSMNEP00000019879Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (323 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
ENSMNEP00000018960Enolase_C domain-containing protein. (184 aa)
ENSMNEP00000018849Uncharacterized protein; Belongs to the LDH/MDH superfamily. (342 aa)
ENSMNEP00000018541Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (302 aa)
ENSMNEP00000018330Ldh_1_N domain-containing protein. (252 aa)
ANGPT2Angiopoietin 2. (496 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
ENSMNEP00000017998Protein kinase domain-containing protein. (356 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENO3Enolase 3. (266 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
ENSMNEP00000016253Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (361 aa)
ENSMNEP00000016245Uncharacterized protein; Belongs to the LDH/MDH superfamily. (319 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
HMOX1Heme oxygenase 1. (288 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1063 aa)
HK3Hexokinase 3. (960 aa)
LTBRLymphotoxin beta receptor. (435 aa)
FCGBPFc fragment of IgG binding protein. (3551 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
LOC105496960Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (389 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
ENSMNEP00000008345L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (323 aa)
EDN1Endothelin 1. (211 aa)
PIK3R2Uncharacterized protein. (668 aa)
HK1Hexokinase 1. (921 aa)
ENSMNEP00000007014Phosphoglycerate kinase. (359 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (379 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
CYBBCytochrome b-245 beta chain. (614 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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