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| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (333 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | PLK2 | Serine/threonine-protein kinase PLK. (685 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | BNIP3 | BCL2 interacting protein 3. (253 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1. (361 aa) |
| | SNAPIN | SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (763 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1306 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | RAG2 | Recombination activating 2. (532 aa) |
| | S1PR1 | Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | S1PR4 | Sphingosine-1-phosphate receptor 4. (384 aa) |
| | GABARAPL2 | GABA type A receptor associated protein like 2. (117 aa) |
| | HOMER1 | Homer scaffold protein 1. (358 aa) |
| | FOXJ2 | Forkhead box J2. (574 aa) |
| | RASGEF1A | RasGEF domain family member 1A. (489 aa) |
| | TPTE2 | Uncharacterized protein. (558 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | TSSK6 | Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa) |
| | STK4 | Serine/threonine kinase 4. (491 aa) |
| | PRMT1 | Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa) |
| | ENSMNEP00000001669 | Uncharacterized protein. (77 aa) |
| | RASGEF1B | RasGEF domain family member 1B. (521 aa) |
| | IGF1 | Insulin like growth factor 1. (208 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | ENSMNEP00000001215 | Uncharacterized protein. (87 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa) |
| | RNF111 | Ring finger protein 111. (1002 aa) |
| | ERAS | ES cell expressed Ras. (233 aa) |
| | IL6 | Interleukin 6. (214 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (433 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | RNF6 | Ring finger protein 6. (701 aa) |
| | SKP2 | S-phase kinase associated protein 2. (424 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | MYO9B | Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2135 aa) |
| | FOXO6 | Forkhead box O6. (627 aa) |
| | PRMT8 | Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa) |
| | SGK3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa) |
| | GABARAP | GABA type A receptor-associated protein. (117 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa) |
| | SLC35E3 | Solute carrier family 35 member E3. (313 aa) |
| | GRAP | GRB2 related adaptor protein. (217 aa) |
| | REM1 | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | SETD7 | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa) |
| | TSSK3 | Testis specific serine kinase 3. (268 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | FOXO4 | Forkhead box O4. (505 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (489 aa) |
| | EP300 | E1A binding protein p300. (2397 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | GEM | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa) |
| | PMEPA1 | Prostate transmembrane protein, androgen induced 1. (287 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | IRS4 | Insulin receptor substrate 4. (1250 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (463 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | HOMER3 | WH1 domain-containing protein. (361 aa) |
| | RRAD | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa) |
| | BCL6B | BCL6B transcription repressor. (475 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | MAPK9 | Mitogen-activated protein kinase 9. (354 aa) |
| | LDLRAD4 | Low density lipoprotein receptor class A domain containing 4. (306 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (138 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1102 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | GRM1 | Glutamate metabotropic receptor 1. (1195 aa) |
| | GABARAPL1 | GABA type A receptor associated protein like 1. (146 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | FOXO3 | Forkhead box O3. (716 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | ENSMNEP00000033022 | Uncharacterized protein. (77 aa) |
| | SUCO | SUN domain containing ossification factor. (1384 aa) |
| | CCNG2 | Cyclin G2; Belongs to the cyclin family. (344 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (608 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (160 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (391 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa) |
| | ENSMNEP00000027902 | Protein kinase domain-containing protein. (365 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | INS | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa) |
| | ENSMNEP00000024840 | Uncharacterized protein. (319 aa) |
| | SGK2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa) |
| | FOXJ3 | Forkhead box J3. (622 aa) |
| | CNTD2 | Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (304 aa) |
| | CCNB3 | Cyclin B3; Belongs to the cyclin family. (1363 aa) |
| | SLC2A4 | Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (559 aa) |
| | G6PC | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | RASL11B | RAS like family 11 member B. (248 aa) |
| | HOMER2 | Homer scaffold protein 2. (356 aa) |
| | BCL6 | BCL6 transcription repressor. (708 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1141 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | STAT3 | Signal transducer and activator of transcription. (660 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | G6PC2 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (353 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | PLK5 | Polo like kinase 5. (299 aa) |
| | IRS2 | Insulin receptor substrate 2. (1334 aa) |
| | ENSMNEP00000017370 | Uncharacterized protein; Belongs to the cyclin family. (341 aa) |
| | FBXO25 | F-box protein 25. (367 aa) |
| | PRMT3 | Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (579 aa) |
| | TMEM232 | Transmembrane protein 232. (657 aa) |
| | FBXO32 | F-box protein 32. (355 aa) |
| | KLF2 | Kruppel like factor 2. (355 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa) |
| | ENSMNEP00000016378 | Protein kinase domain-containing protein. (652 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | ENSMNEP00000015675 | Uncharacterized protein. (105 aa) |
| | SOD2 | Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa) |
| | SGK1 | Non-specific serine/threonine protein kinase. (526 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | IL7R | Interleukin 7 receptor. (459 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | FOXO1 | Forkhead box O1. (655 aa) |
| | PLK4 | Polo like kinase 4. (970 aa) |
| | TSSK4 | Testis specific serine kinase 4. (338 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (574 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | G6PC3 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa) |
| | PIK3R2 | Uncharacterized protein. (668 aa) |
| | REM2 | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa) |
| | LOC105464452 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa) |
| | MYO9A | Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2555 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | CSDE1 | Cold shock domain containing E1. (844 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (582 aa) |
