103 items (Macaca nemestrina) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EI24	EI24 autophagy associated transmembrane protein. (340 aa)
	GORAB	Golgin, RAB6 interacting. (394 aa)
	ENSMNEP00000000191	Uncharacterized protein. (61 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (433 aa)
	LOC105487609	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
	ENSMNEP00000001215	Uncharacterized protein. (87 aa)
	LOC105491771	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	LOC105497820	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	ENSMNEP00000001503	Uncharacterized protein. (73 aa)
	ATR	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
	ENSMNEP00000001669	Uncharacterized protein. (77 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	LOC105495842	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	FAM76B	Family with sequence similarity 76 member B. (339 aa)
	BBC3	BCL2 binding component 3. (261 aa)
	TPTE2	Uncharacterized protein. (558 aa)
	RPRML	Reprimo like. (120 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	LOC105486922	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	ENSMNEP00000004019	Uncharacterized protein; Belongs to the peptidase C14A family. (242 aa)
	LOC105477037	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	RPRM	Reprimo, TP53 dependent G2 arrest mediator homolog. (109 aa)
	LOC105495023	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
	LOC105477715	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	LOC105492342	Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (445 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (379 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (248 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (407 aa)
	FAM76A	Family with sequence similarity 76 member A. (341 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	CDK3	Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (333 aa)
	TRMU	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase. (421 aa)
	FAS	Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (439 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	PIDD1	P53-induced death domain protein 1. (936 aa)
	DDB2	Damage specific DNA binding protein 2. (427 aa)
	SESN3	Sestrin 3. (492 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	HPS5	Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1129 aa)
	TP53AIP1	Tumor protein p53 regulated apoptosis inducing protein 1. (118 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	CD82	Tetraspanin. (266 aa)
	PMAIP1	Uncharacterized protein. (133 aa)
	BID	BH3 interacting domain death agonist. (266 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (260 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (421 aa)
	ENSMNEP00000017370	Uncharacterized protein; Belongs to the cyclin family. (341 aa)
	SESN1	Sestrin 1. (551 aa)
	SIAH1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
	ADGRB2	Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1587 aa)
	ADGRB3	Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
	TNFRSF10A	TNF receptor superfamily member 10a. (309 aa)
	BAX	BCL2 associated X, apoptosis regulator. (203 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (404 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	CNTD2	Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (304 aa)
	TNFRSF10B	TNF receptor superfamily member 10b. (445 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
	ZMAT3	Zinc finger matrin-type 3. (289 aa)
	CHEK1	Checkpoint kinase 1. (493 aa)
	CDKN2A	Cyclin dependent kinase inhibitor 2A. (160 aa)
	TSC2	TSC complex subunit 2. (1807 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	SIVA1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	AIFM2	Apoptosis inducing factor mitochondria associated 2. (373 aa)
	ENSMNEP00000041867	Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
	SERPINB5	Serpin family B member 5; Belongs to the serpin family. (375 aa)
	SHISA5	Shisa family member 5. (238 aa)
	SIAH2	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
	CHEK2	Checkpoint kinase 2. (588 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	ENSMNEP00000039538	PKS_ER domain-containing protein. (271 aa)
	THBS1	Thrombospondin 1. (1173 aa)
	ENSMNEP00000038710	Uncharacterized protein. (122 aa)
	ENSMNEP00000038452	Uncharacterized protein. (396 aa)
	COP1	COP1 E3 ubiquitin ligase. (731 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (291 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
	GTSE1	G2 and S-phase expressed 1. (739 aa)
	C7orf31	Chromosome 7 open reading frame 31. (590 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (339 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	RCHY1	Ring finger and CHY zinc finger domain containing 1. (261 aa)
	SESN2	Sestrin 2. (480 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (487 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (344 aa)
	ENSMNEP00000032397	Uncharacterized protein. (298 aa)
	STEAP3	STEAP3 metalloreductase. (498 aa)
	CCNG1	Cyclin G1; Belongs to the cyclin family. (295 aa)
	ADGRB1	Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1566 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (242 aa)
	PERP	P53 apoptosis effector related to PMP22. (193 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (391 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM2	ENSMNEP00000038710	ENSMNEP00000042011	ENSMNEP00000038710	Apoptosis inducing factor mitochondria associated 2.	Uncharacterized protein.	0.479
AIFM2	SHISA5	ENSMNEP00000042011	ENSMNEP00000040731	Apoptosis inducing factor mitochondria associated 2.	Shisa family member 5.	0.479
APAF1	ATM	ENSMNEP00000012676	ENSMNEP00000001150	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.509
APAF1	BAX	ENSMNEP00000012676	ENSMNEP00000023344	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.745
APAF1	BCL2	ENSMNEP00000012676	ENSMNEP00000023608	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.838
APAF1	BCL2L1	ENSMNEP00000012676	ENSMNEP00000002756	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 1.	0.818
APAF1	CASP8	ENSMNEP00000012676	ENSMNEP00000032718	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.922
APAF1	CASP9	ENSMNEP00000012676	ENSMNEP00000016926	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CYCS	ENSMNEP00000012676	ENSMNEP00000035441	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.977
APAF1	DDB2	ENSMNEP00000012676	ENSMNEP00000010022	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Damage specific DNA binding protein 2.	0.464
APAF1	ENSMNEP00000004019	ENSMNEP00000012676	ENSMNEP00000004019	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.971
APAF1	ENSMNEP00000041867	ENSMNEP00000012676	ENSMNEP00000041867	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.967
APAF1	LOC105477037	ENSMNEP00000012676	ENSMNEP00000004050	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.987
APAF1	LOC105477715	ENSMNEP00000012676	ENSMNEP00000005280	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.987
APAF1	LOC105486922	ENSMNEP00000012676	ENSMNEP00000003672	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.969
APAF1	LOC105487609	ENSMNEP00000012676	ENSMNEP00000000810	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.969
APAF1	LOC105491771	ENSMNEP00000012676	ENSMNEP00000001254	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.969
APAF1	LOC105492342	ENSMNEP00000012676	ENSMNEP00000005628	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.971
APAF1	LOC105495023	ENSMNEP00000012676	ENSMNEP00000004599	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.987
APAF1	LOC105495842	ENSMNEP00000012676	ENSMNEP00000002102	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.969