STRINGSTRING
ENSMNEP00000000212 ENSMNEP00000000212 PIK3CB PIK3CB ENSMNEP00000000769 ENSMNEP00000000769 ERAS ERAS ENSMNEP00000001215 ENSMNEP00000001215 RAB33A RAB33A DDIT4 DDIT4 ENSMNEP00000001669 ENSMNEP00000001669 TANK TANK PRKX PRKX TSSK6 TSSK6 TPTE2 TPTE2 ATG2B ATG2B BCL2L1 BCL2L1 ENSMNEP00000003849 ENSMNEP00000003849 GABARAPL2 GABARAPL2 RRAGA RRAGA RPTOR RPTOR WDR41 WDR41 SQSTM1 SQSTM1 PRKAA2 PRKAA2 EIF2AK4 EIF2AK4 RAB33B RAB33B NRBF2 NRBF2 HMGB4 HMGB4 MAP2K1 MAP2K1 BNIP3 BNIP3 PDIK1L PDIK1L PRKCQ PRKCQ PTEN PTEN ENSMNEP00000007677 ENSMNEP00000007677 ATG7 ATG7 DEPTOR DEPTOR REM2 REM2 ENSMNEP00000007890 ENSMNEP00000007890 PIK3R2 PIK3R2 RAB7B RAB7B ENSMNEP00000008131 ENSMNEP00000008131 ENSMNEP00000008139 ENSMNEP00000008139 ATG13 ATG13 NOL4 NOL4 TP53INP1 TP53INP1 HMGB1 HMGB1 RAB43 RAB43 CTSB CTSB STX17 STX17 ZFYVE1 ZFYVE1 MTOR MTOR STK11 STK11 ENSMNEP00000010344 ENSMNEP00000010344 MTMR3 MTMR3 MRAS MRAS LMLN LMLN PRKAA1 PRKAA1 ATG16L1 ATG16L1 ENSMNEP00000011545 ENSMNEP00000011545 ATG9A ATG9A ENSMNEP00000011718 ENSMNEP00000011718 ENSMNEP00000011766 ENSMNEP00000011766 MAPK1 MAPK1 ENSMNEP00000012002 ENSMNEP00000012002 KCNK1 KCNK1 RAB39B RAB39B ENSMNEP00000012634 ENSMNEP00000012634 NOL4L NOL4L MAPK8 MAPK8 ULK2 ULK2 TSSK4 TSSK4 ENSMNEP00000013739 ENSMNEP00000013739 BECN1 BECN1 CAMKK2 CAMKK2 ENSMNEP00000014610 ENSMNEP00000014610 ATG14 ATG14 SUPT20H SUPT20H RB1CC1 RB1CC1 ENSMNEP00000015675 ENSMNEP00000015675 CRYBB3 CRYBB3 MAPK3 MAPK3 RRAGB RRAGB ENSMNEP00000016083 ENSMNEP00000016083 C9orf72 C9orf72 RHEBL1 RHEBL1 RPS6KB2 RPS6KB2 DUS2 DUS2 RRAS RRAS IRS2 IRS2 ATG5 ATG5 EIF2AK3 EIF2AK3 EIF2S1 EIF2S1 ATG12 ATG12 ENSMNEP00000019154 ENSMNEP00000019154 RAB7A RAB7A ENSMNEP00000019824 ENSMNEP00000019824 RRAGD RRAGD PIK3CA PIK3CA ULK1 ULK1 ERN2 ERN2 SMCR8 SMCR8 LAMP2 LAMP2 DAPK3 DAPK3 RASL11B RASL11B SNAP29 SNAP29 NPAS3 NPAS3 WIPI2 WIPI2 LOC105496847 LOC105496847 BCL2 BCL2 PIK3C3 PIK3C3 ITPR1 ITPR1 HMGB2 HMGB2 ATG16L2 ATG16L2 UVRAG UVRAG MTMR14 MTMR14 VAMP8 VAMP8 INS INS AKT1 AKT1 RRAGC RRAGC RAB39A RAB39A ATG9B ATG9B TSC1 TSC1 ENSMNEP00000027902 ENSMNEP00000027902 PIK3R4 PIK3R4 ARID4A ARID4A DAPK2 DAPK2 AKT2 AKT2 RIT2 RIT2 ATG4B ATG4B ATG101 ATG101 NPAS1 NPAS1 IGF1R IGF1R HIF3A HIF3A STK35 STK35 ATG4C ATG4C PIK3R1 PIK3R1 PIK3CD PIK3CD PRKCD PRKCD PRKACB PRKACB HRAS HRAS RUBCN RUBCN MAP3K7 MAP3K7 RIT1 RIT1 SH3GLB1 SH3GLB1 ATG4A ATG4A ATG2A ATG2A ENSMNEP00000033022 ENSMNEP00000033022 LMLN2 LMLN2 ZFYVE28 ZFYVE28 RRAS2 RRAS2 RAF1 RAF1 DDIT4L DDIT4L GABARAPL1 GABARAPL1 LOC105495891 LOC105495891 AMBRA1 AMBRA1 MAPK9 MAPK9 PRAP1 PRAP1 LAMP1 LAMP1 MLST8 MLST8 VMP1 VMP1 AKT1S1 AKT1S1 PPP1R14B PPP1R14B PDPK1 PDPK1 CSDE1 CSDE1 KRAS KRAS ENSMNEP00000045290 ENSMNEP00000045290 RPS6KB1 RPS6KB1 NRAS NRAS TTC14 TTC14 TP53INP2 TP53INP2 BAD BAD TSC2 TSC2 GABARAP GABARAP DAPK1 DAPK1 RASEF RASEF ERN1 ERN1 MTMR4 MTMR4 RAB8A RAB8A MAP2K2 MAP2K2 ATG4D ATG4D REM1 REM1 RAB19 RAB19 TSSK3 TSSK3 CFLAR CFLAR IGBP1 IGBP1 PPP2CA PPP2CA PRKACA PRKACA SNAP47 SNAP47 HIF1A HIF1A RUBCNL RUBCNL TBK1 TBK1 MAPK10 MAPK10 ATG3 ATG3 PPP2CB PPP2CB CTSL CTSL GEM GEM AKT3 AKT3 IRS4 IRS4 PIK3R3 PIK3R3 RHEB RHEB WIPI1 WIPI1 TRAF6 TRAF6 ENSMNEP00000038197 ENSMNEP00000038197 IRS1 IRS1 ATG10 ATG10 RRAD RRAD KIAA1671 KIAA1671 CRYGN CRYGN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMNEP00000000212Uncharacterized protein. (175 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ENSMNEP00000000769Uncharacterized protein. (209 aa)
ERASES cell expressed Ras. (233 aa)
ENSMNEP00000001215Uncharacterized protein. (87 aa)
RAB33ARAB33A, member RAS oncogene family. (237 aa)
DDIT4DNA damage inducible transcript 4. (233 aa)
ENSMNEP00000001669Uncharacterized protein. (77 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
PRKXProtein kinase X-linked; Belongs to the protein kinase superfamily. (358 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
TPTE2Uncharacterized protein. (558 aa)
ATG2BAutophagy related 2B. (2078 aa)
BCL2L1BCL2 like 1. (233 aa)
ENSMNEP00000003849Uncharacterized protein. (191 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
RRAGARas related GTP binding A. (313 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
WDR41WD repeat domain 41. (459 aa)
SQSTM1Sequestosome 1. (440 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
RAB33BRAB33B, member RAS oncogene family. (229 aa)
NRBF2Nuclear receptor binding factor 2. (287 aa)
HMGB4High mobility group box 4. (191 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
BNIP3BCL2 interacting protein 3. (253 aa)
PDIK1LPDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. (341 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ENSMNEP00000007677Uncharacterized protein. (200 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
DEPTORDEP domain containing MTOR interacting protein. (454 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
ENSMNEP00000007890Uncharacterized protein. (340 aa)
PIK3R2Uncharacterized protein. (668 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
ENSMNEP00000008131Uncharacterized protein. (741 aa)
ENSMNEP00000008139Uncharacterized protein. (111 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
NOL4Nucleolar protein 4. (638 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
HMGB1High mobility group box 1. (215 aa)
RAB43RAB43, member RAS oncogene family. (212 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (302 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (789 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
ENSMNEP00000010344Uncharacterized protein. (206 aa)
MTMR3Myotubularin related protein 3. (1207 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
LMLNLeishmanolysin-like peptidase. (692 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ATG16L1Autophagy related 16 like 1. (624 aa)
ENSMNEP00000011545Uncharacterized protein. (81 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (851 aa)
ENSMNEP00000011718Uncharacterized protein. (188 aa)
ENSMNEP00000011766Uncharacterized protein. (272 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
KCNK1Potassium channel subfamily K member. (336 aa)
RAB39BRAB39B, member RAS oncogene family. (213 aa)
ENSMNEP00000012634Uncharacterized protein. (191 aa)
NOL4LNucleolar protein 4 like. (680 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1035 aa)
TSSK4Testis specific serine kinase 4. (338 aa)
ENSMNEP00000013739Uncharacterized protein. (202 aa)
BECN1Beclin 1. (450 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (648 aa)
ENSMNEP00000014610Uncharacterized protein. (193 aa)
ATG14Autophagy related 14. (493 aa)
SUPT20HSPT20 homolog, SAGA complex component. (779 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
ENSMNEP00000015675Uncharacterized protein. (105 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RRAGBRas related GTP binding B. (349 aa)
ENSMNEP00000016083Uncharacterized protein. (191 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
RHEBL1RHEB like 1. (183 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
DUS2Dihydrouridine synthase 2. (493 aa)
RRASRAS related. (218 aa)
IRS2Insulin receptor substrate 2. (1334 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
ENSMNEP00000019154Uncharacterized protein. (197 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
ENSMNEP00000019824Uncharacterized protein. (194 aa)
RRAGDRas related GTP binding D. (400 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (926 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
DAPK3Death associated protein kinase 3. (429 aa)
RASL11BRAS like family 11 member B. (248 aa)
SNAP29Synaptosome associated protein 29. (258 aa)
NPAS3Neuronal PAS domain protein 3. (814 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (451 aa)
LOC105496847Uncharacterized protein. (362 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
HMGB2Uncharacterized protein. (209 aa)
ATG16L2Autophagy related 16 like 2. (696 aa)
UVRAGUV radiation resistance associated. (699 aa)
MTMR14Myotubularin related protein 14. (650 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RRAGCRas related GTP binding C. (399 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (922 aa)
TSC1TSC complex subunit 1. (1138 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
ARID4AAT-rich interaction domain 4A. (1262 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RIT2Ras like without CAAX 2. (217 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (508 aa)
ATG101Autophagy related 101. (218 aa)
NPAS1Neuronal PAS domain protein 1. (591 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (570 aa)
STK35Serine/threonine kinase 35. (533 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PRKCDProtein kinase C. (729 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RUBCNRubicon autophagy regulator. (1011 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RIT1Ras like without CAAX 1. (219 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (402 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
ATG2AAutophagy related 2A. (1968 aa)
ENSMNEP00000033022Uncharacterized protein. (77 aa)
LMLN2Leishmanolysin-like peptidase. (785 aa)
ZFYVE28Zinc finger FYVE-type containing 28. (888 aa)
RRAS2RAS related 2. (204 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
DDIT4LDNA damage inducible transcript 4 like. (193 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
LOC105495891Uncharacterized protein. (201 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
PRAP1Uncharacterized protein. (153 aa)
LAMP1Lysosomal associated membrane protein 1. (416 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
VMP1Vacuole membrane protein 1. (406 aa)
AKT1S1AKT1 substrate 1. (276 aa)
PPP1R14BUncharacterized protein. (208 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (582 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSMNEP00000045290Uncharacterized protein. (161 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TTC14Tetratricopeptide repeat domain 14. (771 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (220 aa)
BADBCL2 associated agonist of cell death. (167 aa)
TSC2TSC complex subunit 2. (1807 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
DAPK1Death associated protein kinase 1. (1440 aa)
RASEFRAS and EF-hand domain containing. (743 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (447 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
RAB19RAB19, member RAS oncogene family. (217 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
IGBP1Uncharacterized protein. (339 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
SNAP47Synaptosome associated protein 47. (419 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
RUBCNLRubicon like autophagy enhancer. (677 aa)
TBK1TANK binding kinase 1. (729 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
ATG3Autophagy-related protein 3. (314 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (341 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IRS4Insulin receptor substrate 4. (1250 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (462 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ENSMNEP00000038197Uncharacterized protein. (121 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
ATG10Autophagy related 10. (228 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
KIAA1671KIAA1671. (1803 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (182 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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