STRINGSTRING
TLE5 TLE5 TLE1 TLE1 CIR1 CIR1 NCOA7 NCOA7 JAG2 JAG2 CNPY3 CNPY3 HES5 HES5 CREBBP CREBBP CTBP2 CTBP2 EP300 EP300 NCSTN NCSTN MAML2 MAML2 RFNG RFNG TLE4 TLE4 MINDY3 MINDY3 DVL1 DVL1 NCOR2 NCOR2 NOTCH4 NOTCH4 MAML3 MAML3 LFNG LFNG DLL4 DLL4 ENSMNEP00000031398 ENSMNEP00000031398 DTX3L DTX3L MFNG MFNG PSENEN PSENEN DTX4 DTX4 JAG1 JAG1 CTBP1 CTBP1 RBPJ RBPJ HEY2 HEY2 PSEN1 PSEN1 TLE2 TLE2 HDAC1 HDAC1 HES1 HES1 RBPJL RBPJL TLE3 TLE3 ATXN1 ATXN1 PSEN2 PSEN2 KAT2A KAT2A DTX2 DTX2 ENSMNEP00000022622 ENSMNEP00000022622 APH1B APH1B NUMB NUMB APH1A APH1A NOTCH3 NOTCH3 HEY1 HEY1 DLL3 DLL3 PTCRA PTCRA NUMBL NUMBL BPTF BPTF ENSMNEP00000017045 ENSMNEP00000017045 TLE6 TLE6 ENSMNEP00000016650 ENSMNEP00000016650 PTPRE PTPRE ENSMNEP00000015951 ENSMNEP00000015951 MAML1 MAML1 ADAM17 ADAM17 EYS EYS DVL3 DVL3 NOTCH1 NOTCH1 LOC105466285 LOC105466285 PTPRA PTPRA DVL2 DVL2 NOTCH2 NOTCH2 KAT2B KAT2B DLL1 DLL1 VWDE VWDE SNW1 SNW1 DTX3 DTX3 ATXN1L ATXN1L GPSM3 GPSM3 DTX1 DTX1 OXR1 OXR1 HEYL HEYL HDAC2 HDAC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLE5TLE family member 5, transcriptional modulator. (264 aa)
TLE1TLE family member 1, transcriptional corepressor. (779 aa)
CIR1Corepressor interacting with RBPJ, 1. (374 aa)
NCOA7Nuclear receptor coactivator 7. (942 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1238 aa)
CNPY3Canopy FGF signaling regulator 3. (277 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
CREBBPCREB binding protein. (2442 aa)
CTBP2C-terminal binding protein 2. (987 aa)
EP300E1A binding protein p300. (2397 aa)
NCSTNNicastrin. (721 aa)
MAML2Mastermind like transcriptional coactivator 2. (1152 aa)
RFNGBeta-1,3-N-acetylglucosaminyltransferase. (331 aa)
TLE4TLE family member 4, transcriptional corepressor. (805 aa)
MINDY3MINDY lysine 48 deubiquitinase 3. (445 aa)
DVL1Dishevelled segment polarity protein 1. (690 aa)
NCOR2Nuclear receptor corepressor 2. (2510 aa)
NOTCH4Notch receptor 4. (2001 aa)
MAML3Mastermind like transcriptional coactivator 3. (1134 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (375 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
ENSMNEP00000031398Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (452 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (740 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (321 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
DTX4Deltex E3 ubiquitin ligase 4. (619 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
TLE2TLE family member 2, transcriptional corepressor. (755 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (483 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
TLE3TLE family member 3, transcriptional corepressor. (778 aa)
ATXN1Ataxin 1. (818 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
DTX2Deltex E3 ubiquitin ligase 2. (622 aa)
ENSMNEP00000022622Uncharacterized protein. (1137 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
NUMBNUMB endocytic adaptor protein. (652 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
NOTCH3Notch receptor 3. (2275 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
DLL3Delta like canonical Notch ligand 3. (587 aa)
PTCRAPre T cell antigen receptor alpha. (281 aa)
NUMBLNUMB like endocytic adaptor protein. (607 aa)
BPTFBromodomain PHD finger transcription factor. (3000 aa)
ENSMNEP00000017045Hist_deacetyl domain-containing protein. (247 aa)
TLE6TLE family member 6, subcortical maternal complex member. (550 aa)
ENSMNEP00000016650Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa)
PTPREReceptor-type tyrosine-protein phosphatase. (700 aa)
ENSMNEP00000015951Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (443 aa)
MAML1Mastermind like transcriptional coactivator 1. (969 aa)
ADAM17ADAM metallopeptidase domain 17. (803 aa)
EYSEyes shut homolog. (3165 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
NOTCH1Notch receptor 1. (2556 aa)
LOC105466285Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (437 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (804 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
NOTCH2Notch receptor 2. (2471 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (800 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
VWDEVon Willebrand factor D and EGF domains. (1590 aa)
SNW1SNW domain containing 1. (571 aa)
DTX3Deltex E3 ubiquitin ligase 3. (350 aa)
ATXN1LAtaxin 1 like. (689 aa)
GPSM3G protein signaling modulator 3. (160 aa)
DTX1Deltex E3 ubiquitin ligase 1. (622 aa)
OXR1Oxidation resistance 1. (874 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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