STRINGSTRING
SUFU SUFU CUL1 CUL1 BCL2 BCL2 SMO SMO FBXW11 FBXW11 DHH DHH CSNK1G3 CSNK1G3 ENSMNEP00000017273 ENSMNEP00000017273 CCND2 CCND2 MOSMO MOSMO HHIP HHIP PRKACA PRKACA IHH IHH SHH SHH EVC2 EVC2 KIF7 KIF7 CCND1 CCND1 TSPAN33 TSPAN33 SMURF1 SMURF1 ARR3 ARR3 MGRN1 MGRN1 KIF3A KIF3A PTCH2 PTCH2 LMBR1L LMBR1L GRK3 GRK3 MEGF8 MEGF8 GLI2 GLI2 LMBR1 LMBR1 CDON CDON LOC105464452 LOC105464452 GPR161 GPR161 GSK3B GSK3B GLI3 GLI3 LRP2 LRP2 BOC BOC GAS1 GAS1 ATRN ATRN GRK2 GRK2 ARRB2 ARRB2 ARRB1 ARRB1 ENSMNEP00000034709 ENSMNEP00000034709 CUL3 CUL3 ATRNL1 ATRNL1 LRP4 LRP4 PRKACB PRKACB SPOPL SPOPL PTCH1 PTCH1 KIF27 KIF27 EVC EVC CSNK1G2 CSNK1G2 GLI1 GLI1 CSNK1A1 CSNK1A1 ENSMNEP00000025825 ENSMNEP00000025825 CSNK1D CSNK1D CSNK1A1L CSNK1A1L CSNK1G1 CSNK1G1 SPOP SPOP BTRC BTRC SMURF2 SMURF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (526 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (657 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (455 aa)
ENSMNEP00000017273Protein kinase domain-containing protein. (311 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
MOSMOModulator of smoothened. (167 aa)
HHIPHedgehog interacting protein. (700 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
EVC2EvC ciliary complex subunit 2. (1308 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1344 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
TSPAN33Tetraspanin. (283 aa)
SMURF1SMAD specific E3 ubiquitin protein ligase 1. (641 aa)
ARR3Arrestin 3. (389 aa)
MGRN1Mahogunin ring finger 1. (495 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
PTCH2Patched 2. (1204 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
MEGF8Multiple EGF like domains 8. (2846 aa)
GLI2GLI family zinc finger 2. (1586 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (524 aa)
CDONCell adhesion associated, oncogene regulated. (1287 aa)
LOC105464452Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (550 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
GLI3GLI family zinc finger 3. (1580 aa)
LRP2LDL receptor related protein 2. (4655 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1116 aa)
GAS1Growth arrest specific 1. (347 aa)
ATRNAttractin. (1430 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
ARRB2Arrestin beta 2. (454 aa)
ARRB1Arrestin beta 1. (443 aa)
ENSMNEP00000034709Uncharacterized protein. (439 aa)
CUL3Cullin 3; Belongs to the cullin family. (767 aa)
ATRNL1Attractin like 1. (1378 aa)
LRP4LDL receptor related protein 4. (1873 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
SPOPLSpeckle type BTB/POZ protein like. (399 aa)
PTCH1Patched 1. (1449 aa)
KIF27Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1361 aa)
EVCEvC ciliary complex subunit 1. (992 aa)
CSNK1G2Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (415 aa)
GLI1GLI family zinc finger 1. (1065 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (365 aa)
ENSMNEP00000025825MATH domain-containing protein. (362 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
CSNK1A1LCasein kinase 1 alpha 1 like. (243 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (467 aa)
SPOPSpeckle type BTB/POZ protein. (373 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
SMURF2E3 ubiquitin-protein ligase. (740 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.