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GDF5 GDF5 FBN2 FBN2 ADAMTSL4 ADAMTSL4 SNAPIN SNAPIN PITX3 PITX3 SMAD1 SMAD1 E2F4 E2F4 ENSMNEP00000005419 ENSMNEP00000005419 MYC MYC TGIF2LY TGIF2LY ACVR1C ACVR1C BMP7 BMP7 ENSMNEP00000001266 ENSMNEP00000001266 GREM2 GREM2 LEFTY1 LEFTY1 PKNOX1 PKNOX1 GDF6 GDF6 BAMBI BAMBI CUL1 CUL1 BMP6 BMP6 TGIF1 TGIF1 LTBP1 LTBP1 SMAD9 SMAD9 SMAD6 SMAD6 PPP2R1A PPP2R1A ENSMNEP00000021101 ENSMNEP00000021101 SMURF2 SMURF2 ZFYVE9 ZFYVE9 ID3 ID3 ROCK1 ROCK1 PITX2 PITX2 TNF TNF NOG NOG RBX1 RBX1 E2F5 E2F5 USF2 USF2 ID2 ID2 ID1 ID1 SMAD7 SMAD7 HAMP HAMP MATN4 MATN4 INHBE INHBE BMPR1B BMPR1B ZFYVE16 ZFYVE16 MATN2 MATN2 TGFBR2 TGFBR2 CDKN2B CDKN2B SP1 SP1 DCN DCN ACVR1B ACVR1B INHBA INHBA NEO1 NEO1 LTBP3 LTBP3 RHOA RHOA LOC105478551 LOC105478551 THBS1 THBS1 SMAD5 SMAD5 AMHR2 AMHR2 FBN3 FBN3 TGFB1 TGFB1 PPP2CB PPP2CB CHRD CHRD EP300 EP300 THSD4 THSD4 TGFB2 TGFB2 CREBBP CREBBP BMP8A BMP8A PPP2CA PPP2CA TGFB3 TGFB3 ACVR2A ACVR2A INHBC INHBC ENSMNEP00000042218 ENSMNEP00000042218 LTBP4 LTBP4 HJV HJV TFDP1 TFDP1 IFNG IFNG RPS6KB1 RPS6KB1 NBL1 NBL1 ID4 ID4 SMAD2 SMAD2 FMOD FMOD LDAH LDAH ACVR1 ACVR1 RBL1 RBL1 RHOC RHOC BMP2 BMP2 GDF7 GDF7 BMP4 BMP4 RGMA RGMA NODAL NODAL LTBP2 LTBP2 PPP2R1B PPP2R1B PKNOX2 PKNOX2 BMP8B BMP8B ACVR2B ACVR2B ANKFN1 ANKFN1 SMAD3 SMAD3 AMH AMH BMPR1A BMPR1A INTS8 INTS8 BMP5 BMP5 BMPR2 BMPR2 SKP1 SKP1 RGMB RGMB RPS6KB2 RPS6KB2 ENSMNEP00000015849 ENSMNEP00000015849 MAPK3 MAPK3 FBN1 FBN1 TGFBR1 TGFBR1 PITX1 PITX1 FSTL3 FSTL3 SMAD4 SMAD4 SMURF1 SMURF1 TGIF2 TGIF2 INHBB INHBB MAPK1 MAPK1 FST FST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF5Growth differentiation factor 5. (499 aa)
FBN2Fibrillin 2. (2912 aa)
ADAMTSL4ADAMTS like 4. (1100 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
PITX3Homeobox protein. (302 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
E2F4E2F transcription factor 4. (415 aa)
ENSMNEP00000005419Uncharacterized protein. (114 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
TGIF2LYTGFB induced factor homeobox 2 like Y-linked. (177 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ENSMNEP00000001266Uncharacterized protein. (234 aa)
GREM2Gremlin. (168 aa)
LEFTY1Left-right determination factor. (366 aa)
PKNOX1PBX/knotted 1 homeobox 1. (436 aa)
GDF6Growth differentiation factor 6. (455 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
BMP6Bone morphogenetic protein 6. (513 aa)
TGIF1TGFB induced factor homeobox 1. (286 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1722 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
ENSMNEP00000021101Zf-rbx1 domain-containing protein. (93 aa)
SMURF2E3 ubiquitin-protein ligase. (740 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
PITX2Homeobox protein. (325 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
RBX1RING-type domain-containing protein. (108 aa)
E2F5E2F transcription factor 5. (346 aa)
USF2Upstream transcription factor 2, c-fos interacting. (365 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
SMAD7Mothers against decapentaplegic homolog. (488 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
MATN4Matrilin 4. (622 aa)
INHBEInhibin subunit beta E. (351 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZFYVE16Zinc finger FYVE-type containing 16. (1540 aa)
MATN2Matrilin 2. (937 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
SP1Sp1 transcription factor. (786 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
INHBAInhibin subunit beta A. (426 aa)
NEO1Neogenin 1. (1498 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1298 aa)
RHOARas homolog family member A. (193 aa)
LOC105478551Left-right determination factor. (366 aa)
THBS1Thrombospondin 1. (1173 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (572 aa)
FBN3Fibrillin 3. (2697 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (946 aa)
EP300E1A binding protein p300. (2397 aa)
THSD4Thrombospondin type 1 domain containing 4. (1017 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CREBBPCREB binding protein. (2442 aa)
BMP8ATGF_BETA_2 domain-containing protein. (402 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
INHBCInhibin subunit beta C. (352 aa)
ENSMNEP00000042218Uncharacterized protein; Belongs to the SKP1 family. (171 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1608 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
TFDP1Transcription factor. (410 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
NBL1NBL1, DAN family BMP antagonist. (216 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FMODFibromodulin. (376 aa)
LDAHLipid droplet associated hydrolase. (372 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
RBL1RB transcriptional corepressor like 1. (1137 aa)
RHOCRas homolog family member C. (193 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GDF7Growth differentiation factor 7. (448 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
NODALNodal growth differentiation factor. (347 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
PKNOX2PBX/knotted 1 homeobox 2. (472 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
ANKFN1Ankyrin repeat and fibronectin type III domain containing 1. (1149 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
AMHAnti-Mullerian hormone. (562 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
INTS8Integrator complex subunit 8. (985 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (479 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENSMNEP00000015849Transcription factor. (392 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
FBN1Fibrillin 1. (2871 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
PITX1Homeobox protein. (348 aa)
FSTL3Follistatin like 3. (263 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMURF1SMAD specific E3 ubiquitin protein ligase 1. (641 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
INHBBInhibin subunit beta B. (407 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
FSTFollistatin. (344 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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