STRINGSTRING
MAPK14 MAPK14 IL1B IL1B LOC105496996 LOC105496996 TNFRSF11B TNFRSF11B NFKBIA NFKBIA MAP3K7 MAP3K7 LOC105498220 LOC105498220 LCP2 LCP2 RAC1 RAC1 ENSMNEP00000031218 ENSMNEP00000031218 FOSB FOSB PIK3CD PIK3CD TYK2 TYK2 PIK3R1 PIK3R1 TNF TNF IFNB1 IFNB1 AKT2 AKT2 SYK SYK CSF1 CSF1 RELA RELA ENSMNEP00000027902 ENSMNEP00000027902 BTK BTK PPP3CA PPP3CA GRB2 GRB2 LCK LCK RELB RELB MAP2K6 MAP2K6 TREM2 TREM2 AKT1 AKT1 MITF MITF GAB4 GAB4 FCGR2B FCGR2B ENSMNEP00000023973 ENSMNEP00000023973 NOXA1 NOXA1 MAP2K7 MAP2K7 IFNGR2 IFNGR2 NFATC2 NFATC2 STAT2 STAT2 PIK3CA PIK3CA SIRPB1 SIRPB1 FCGR1A FCGR1A ENSMNEP00000019155 ENSMNEP00000019155 LOC105497316 LOC105497316 IGSF1 IGSF1 CTSK CTSK NCF4 NCF4 NCF1 NCF1 PPP3CB PPP3CB SIRPD SIRPD MAPK3 MAPK3 NCF2 NCF2 TGFBR1 TGFBR1 TNFSF11 TNFSF11 FOS FOS IRF9 IRF9 BLNK BLNK LILRA4 LILRA4 TEC TEC CAMK4 CAMK4 MAPK8 MAPK8 CHUK CHUK ENSMNEP00000012002 ENSMNEP00000012002 CYLD CYLD CREB1 CREB1 MAPK11 MAPK11 MAPK1 MAPK1 NFKB2 NFKB2 TNFRSF1A TNFRSF1A NFKB1 NFKB1 IL1R1 IL1R1 LILRA5 LILRA5 FOSL2 FOSL2 ITGB3 ITGB3 FYN FYN PIK3R2 PIK3R2 ENSMNEP00000007926 ENSMNEP00000007926 SIRPG SIRPG FHL2 FHL2 PTK6 PTK6 PPARG PPARG SPI1 SPI1 LILRB5 LILRB5 MAP2K1 MAP2K1 TNFRSF11A TNFRSF11A SRMS SRMS SQSTM1 SQSTM1 TRAF2 TRAF2 SIRPA SIRPA ACP5 ACP5 TAB2 TAB2 SOCS1 SOCS1 MAP3K14 MAP3K14 NFATC1 NFATC1 PLCG2 PLCG2 ENSMNEP00000002451 ENSMNEP00000002451 ENSMNEP00000002263 ENSMNEP00000002263 JAK1 JAK1 SOCS3 SOCS3 JUNB JUNB STAT1 STAT1 PIK3CB PIK3CB NOX1 NOX1 IKBKG IKBKG IKBKB IKBKB IL1A IL1A CYBA CYBA MAPK13 MAPK13 GAB2 GAB2 TGFBR2 TGFBR2 CSF1R CSF1R MAPK9 MAPK9 IFNAR2 IFNAR2 OSCAR OSCAR TYROBP TYROBP TRAF6 TRAF6 RELCH RELCH PIK3R3 PIK3R3 TAB1 TAB1 AKT3 AKT3 IFNGR1 IFNGR1 MAPK12 MAPK12 ENSMNEP00000039463 ENSMNEP00000039463 TGFB1 TGFB1 PPP3CC PPP3CC MAPK10 MAPK10 TGFB2 TGFB2 FOSL1 FOSL1 CALCR CALCR PPP3R1 PPP3R1 IFNG IFNG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK14Mitogen-activated protein kinase. (360 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
LOC105496996Ig-like domain-containing protein. (481 aa)
TNFRSF11BTNF receptor superfamily member 11b. (428 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LOC105498220Uncharacterized protein. (342 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
RAC1Rac family small GTPase 1. (211 aa)
ENSMNEP00000031218Uncharacterized protein. (564 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (302 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IFNB1Interferon beta 1. (187 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SYKTyrosine-protein kinase. (629 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
BTKTyrosine-protein kinase. (659 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LCKTyrosine-protein kinase. (540 aa)
RELBRELB proto-oncogene, NF-kB subunit. (547 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MITFMelanocyte inducing transcription factor. (517 aa)
GAB4GRB2 associated binding protein family member 4. (533 aa)
FCGR2BUncharacterized protein. (313 aa)
ENSMNEP00000023973Ig-like domain-containing protein. (543 aa)
NOXA1NADPH oxidase activator 1. (476 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (384 aa)
IFNGR2Interferon gamma receptor 2. (312 aa)
NFATC2Nuclear factor of activated T cells 2. (921 aa)
STAT2Signal transducer and activator of transcription. (852 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SIRPB1Uncharacterized protein. (422 aa)
FCGR1AUncharacterized protein. (357 aa)
ENSMNEP00000019155Interfer-bind domain-containing protein. (338 aa)
LOC105497316Uncharacterized protein. (657 aa)
IGSF1Immunoglobulin superfamily member 1. (1354 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (348 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
SIRPDSignal regulatory protein delta. (198 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IRF9Interferon regulatory factor 9. (392 aa)
BLNKB cell linker. (456 aa)
LILRA4Leukocyte immunoglobulin like receptor A4. (462 aa)
TECTyrosine-protein kinase. (630 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
LILRA5Leukocyte immunoglobulin like receptor A5. (299 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3R2Uncharacterized protein. (668 aa)
ENSMNEP00000007926Uncharacterized protein. (483 aa)
SIRPGSignal regulatory protein gamma. (387 aa)
FHL2Four and a half LIM domains 2. (389 aa)
PTK6Tyrosine-protein kinase. (397 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
LILRB5Leukocyte immunoglobulin like receptor B5. (591 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
TNFRSF11ATNF receptor superfamily member 11a. (616 aa)
SRMSTyrosine-protein kinase. (492 aa)
SQSTM1Sequestosome 1. (440 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
SIRPAUncharacterized protein. (507 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
NFATC1Nuclear factor of activated T cells 1. (988 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ENSMNEP00000002451Uncharacterized protein. (497 aa)
ENSMNEP00000002263Uncharacterized protein. (329 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
NOX1NADPH oxidase 1. (564 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (224 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
GAB2GRB2 associated binding protein 2. (677 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
IFNAR2Uncharacterized protein. (516 aa)
OSCAROsteoclast associated Ig-like receptor. (300 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (144 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ENSMNEP00000039463Uncharacterized protein. (477 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (517 aa)
PPP3R1Uncharacterized protein. (189 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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