STRINGSTRING
BIRC5 BIRC5 APC APC AXIN2 AXIN2 DLG4 DLG4 SAV1 SAV1 LATS2 LATS2 CTNNB1 CTNNB1 NKD2 NKD2 BMP7 BMP7 BBC3 BBC3 ENSMNEP00000002161 ENSMNEP00000002161 ACTG1 ACTG1 ACTL7B ACTL7B FZD10 FZD10 MYC MYC ACTRT1 ACTRT1 WNT5A WNT5A TEAD1 TEAD1 PATJ PATJ WNT10B WNT10B MPP5 MPP5 PPP2R2A PPP2R2A FZD5 FZD5 SOX3 SOX3 MYO15B MYO15B SOX2 SOX2 WNT8B WNT8B DLG5 DLG5 FZD7 FZD7 SMAD1 SMAD1 GSK3B GSK3B SERPINE1 SERPINE1 WWC1 WWC1 YWHAG YWHAG LOC105464452 LOC105464452 STK3 STK3 LLGL2 LLGL2 WNT9A WNT9A GDF5 GDF5 ENSMNEP00000009204 ENSMNEP00000009204 WWTR1 WWTR1 GLI2 GLI2 SCRIB SCRIB FZD4 FZD4 WNT4 WNT4 NKD1 NKD1 LRRC1 LRRC1 RASSF1 RASSF1 DVL2 DVL2 DLG3 DLG3 DVL3 DVL3 TEAD2 TEAD2 SMAD4 SMAD4 ITGB2 ITGB2 WNT7B WNT7B WNT6 WNT6 PPP2R2B PPP2R2B CCND2 CCND2 LLGL1 LLGL1 PPP2R2C PPP2R2C TGFBR1 TGFBR1 PARD6G PARD6G YAP1 YAP1 ENSMNEP00000016333 ENSMNEP00000016333 FGF1 FGF1 BMPR2 BMPR2 PPP1CB PPP1CB BMP5 BMP5 BMPR1A BMPR1A APC2 APC2 AMH AMH SMAD3 SMAD3 DLG2 DLG2 FBXW11 FBXW11 MOB1A MOB1A RASSF6 RASSF6 AJUBA AJUBA ENSMNEP00000020290 ENSMNEP00000020290 ACTB ACTB BMP8B BMP8B ENSMNEP00000020581 ENSMNEP00000020581 SNAI2 SNAI2 PPP2R1A PPP2R1A CCN2 CCN2 ENSMNEP00000021363 ENSMNEP00000021363 CSNK1D CSNK1D PARD3 PARD3 FZD2 FZD2 ENSMNEP00000022738 ENSMNEP00000022738 WNT8A WNT8A PARD6B PARD6B BMP6 BMP6 TEAD3 TEAD3 AFP AFP GDF6 GDF6 TP73 TP73 WNT2 WNT2 YWHAQ YWHAQ ENSMNEP00000024827 ENSMNEP00000024827 WNT9B WNT9B PPP2R1B PPP2R1B AMOT AMOT BMP4 BMP4 GDF7 GDF7 AREG AREG PARD6A PARD6A BMP2 BMP2 WNT3A WNT3A WNT2B WNT2B LDAH LDAH SMAD2 SMAD2 WNT7A WNT7A WNT5B WNT5B ENSMNEP00000028540 ENSMNEP00000028540 WNT16 WNT16 CCND3 CCND3 PRKCZ PRKCZ BIRC2 BIRC2 ENSMNEP00000029305 ENSMNEP00000029305 ACTL7A ACTL7A ACTRT2 ACTRT2 NF2 NF2 YWHAB YWHAB PPP1CC PPP1CC ENSMNEP00000031713 ENSMNEP00000031713 ID2 ID2 ID1 ID1 TP53BP2 TP53BP2 TCF7L2 TCF7L2 SMAD7 SMAD7 YWHAH YWHAH CDH1 CDH1 FZD3 FZD3 BIRC3 BIRC3 BMPR1B BMPR1B ENSMNEP00000034709 ENSMNEP00000034709 CCND1 CCND1 MYO15A MYO15A CRB2 CRB2 CTNNA3 CTNNA3 TGFBR2 TGFBR2 PPP2R2D PPP2R2D DVL1 DVL1 YWHAZ YWHAZ ENSMNEP00000036686 ENSMNEP00000036686 TEAD4 TEAD4 AXIN1 AXIN1 LIMD1 LIMD1 ENSMNEP00000038177 ENSMNEP00000038177 FZD8 FZD8 ENSMNEP00000038522 ENSMNEP00000038522 FRMD1 FRMD1 PPP1CA PPP1CA WNT11 WNT11 LATS1 LATS1 WTIP WTIP FZD6 FZD6 TGFB1 TGFB1 PPP2CB PPP2CB CRB1 CRB1 YWHAE YWHAE PRKCI PRKCI CTNNA1 CTNNA1 TGFB2 TGFB2 ENSMNEP00000041206 ENSMNEP00000041206 BMP8A BMP8A PPP2CA PPP2CA TGFB3 TGFB3 LEF1 LEF1 WNT1 WNT1 BTRC BTRC WNT10A WNT10A TCF7 TCF7 WNT3 WNT3 FRMD6 FRMD6 DLG1 DLG1 MOB1B MOB1B TCF7L1 TCF7L1 ACTL8 ACTL8 CTNNA2 CTNNA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BIRC5Uncharacterized protein. (147 aa)
APCAPC regulator of WNT signaling pathway. (2864 aa)
AXIN2Axin 2. (844 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
LATS2Non-specific serine/threonine protein kinase. (1086 aa)
CTNNB1Catenin beta 1. (781 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (442 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BBC3BCL2 binding component 3. (261 aa)
ENSMNEP00000002161Uncharacterized protein. (142 aa)
ACTG1Actin gamma 1. (377 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
PATJPATJ crumbs cell polarity complex component. (1802 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
SOX3SRY-box transcription factor 3. (446 aa)
MYO15BMyosin XVB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2999 aa)
SOX2SRY-box transcription factor 2. (319 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (379 aa)
WWC1WW and C2 domain containing 1. (1119 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
LOC105464452Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
STK3Serine/threonine kinase 3. (519 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1020 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
GDF5Growth differentiation factor 5. (499 aa)
ENSMNEP0000000920414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (224 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
GLI2GLI family zinc finger 2. (1586 aa)
SCRIBScribble planar cell polarity protein. (1698 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
RASSF1Ras association domain family member 1. (340 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (863 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
TEAD2TEA domain transcription factor 2. (448 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ITGB2Integrin beta. (921 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1049 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
YAP1Yes associated protein 1. (506 aa)
ENSMNEP0000001633314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (190 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
AMHAnti-Mullerian hormone. (562 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
MOB1AMOB kinase activator 1A. (216 aa)
RASSF6Ras association domain family member 6. (443 aa)
AJUBAAjuba LIM protein. (538 aa)
ENSMNEP0000002029014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (125 aa)
ACTBActin beta. (379 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
ENSMNEP0000002058114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CCN2Cellular communication network factor 2. (387 aa)
ENSMNEP00000021363Uncharacterized protein. (369 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
PARD3Par-3 family cell polarity regulator. (1353 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (562 aa)
ENSMNEP0000002273814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (220 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
BMP6Bone morphogenetic protein 6. (513 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (428 aa)
AFPAlpha fetoprotein. (622 aa)
GDF6Growth differentiation factor 6. (455 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
ENSMNEP0000002482714_3_3 domain-containing protein; Belongs to the 14-3-3 family. (269 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
AMOTAngiomotin. (1101 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF7Growth differentiation factor 7. (448 aa)
AREGAmphiregulin. (274 aa)
PARD6APar-6 family cell polarity regulator alpha. (344 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
LDAHLipid droplet associated hydrolase. (372 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSMNEP00000028540Uncharacterized protein. (139 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (242 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
ENSMNEP0000002930514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (214 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (377 aa)
NF2Neurofibromin 2. (595 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
ENSMNEP0000003171314_3_3 domain-containing protein. (92 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
TP53BP2Tumor protein p53 binding protein 2. (1134 aa)
TCF7L2Transcription factor 7 like 2. (523 aa)
SMAD7Mothers against decapentaplegic homolog. (488 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (668 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSMNEP00000034709Uncharacterized protein. (439 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MYO15AMyosin XVA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3536 aa)
CRB2Crumbs cell polarity complex component 2. (1287 aa)
CTNNA3Catenin alpha 3. (895 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
DVL1Dishevelled segment polarity protein 1. (690 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (257 aa)
ENSMNEP0000003668614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (234 aa)
TEAD4TEA domain transcription factor 4. (454 aa)
AXIN1Axin 1. (867 aa)
LIMD1LIM domains containing 1. (676 aa)
ENSMNEP00000038177Uncharacterized protein; Belongs to the actin family. (156 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (627 aa)
ENSMNEP00000038522Uncharacterized protein. (795 aa)
FRMD1FERM domain containing 1. (583 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
LATS1Large tumor suppressor kinase 1. (1129 aa)
WTIPWT1 interacting protein. (428 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
CTNNA1Catenin alpha 1. (906 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ENSMNEP00000041206Uncharacterized protein; Belongs to the actin family. (163 aa)
BMP8ATGF_BETA_2 domain-containing protein. (402 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
TCF7Transcription factor 7. (496 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
FRMD6FERM domain containing 6. (622 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (947 aa)
MOB1BMOB kinase activator 1B. (221 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
CTNNA2Catenin alpha 2. (953 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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