60 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSMNEP00000003956	RPOL9 domain-containing protein. (101 aa)
	POLR3H	RNA polymerase III subunit H. (204 aa)
	POLR2K	Uncharacterized protein. (58 aa)
	POLR2L	RNA polymerase II subunit L. (67 aa)
	POLR1C	RNA polymerase I and III subunit C. (350 aa)
	IRF7	Interferon regulatory factor 7. (504 aa)
	POLR3GL	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (218 aa)
	PIWIL2	Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (960 aa)
	POLR3G	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (223 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (693 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (968 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	AIM2	Absent in melanoma 2. (343 aa)
	ENSMNEP00000013313	Uncharacterized protein. (152 aa)
	ENSMNEP00000013537	C-C motif chemokine. (103 aa)
	ADAR	Adenosine deaminase RNA specific. (1364 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (518 aa)
	POLR3F	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
	ENSMNEP00000019120	RNA_pol_Rpb5_N domain-containing protein. (175 aa)
	ENSMNEP00000019366	Uncharacterized protein. (69 aa)
	POLR2E	RNA polymerase II subunit E. (211 aa)
	CCL5	C-C motif chemokine. (91 aa)
	POLR3A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1353 aa)
	LOC105490206	RNA_pol_L_2 domain-containing protein. (133 aa)
	IFNA6	Interferon alpha 6. (190 aa)
	IL6	Interleukin 6. (214 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa)
	ENSMNEP00000023427	Uncharacterized protein. (198 aa)
	POLR2H	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	IRF3	Interferon regulatory factor 3. (422 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (548 aa)
	IFNB1	Interferon beta 1. (187 aa)
	LOC105498418	Uncharacterized protein. (190 aa)
	ENSMNEP00000029296	RNA_pol_L_2 domain-containing protein. (125 aa)
	STING1	Transmembrane protein 173. (379 aa)
	POLR3D	RNA polymerase III subunit D. (397 aa)
	POLR3E	RNA polymerase III subunit E. (709 aa)
	NFKBIA	NFKB inhibitor alpha. (317 aa)
	MAVS	Mitochondrial antiviral signaling protein. (541 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	LOC105485102	C-C motif chemokine. (92 aa)
	POLR3C	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	IFNA14	Interferon alpha 14. (137 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	IL33	Interleukin 33. (270 aa)
	POLR2K-2	Uncharacterized protein. (67 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	LOC105498430	Uncharacterized protein. (189 aa)
	ZBP1	Z-DNA binding protein 1. (420 aa)
	POLR2F	RNA polymerase II subunit F. (158 aa)
	POLR3B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1148 aa)
	NFKBIB	NFKB inhibitor beta. (356 aa)
	ENSMNEP00000044641	Uncharacterized protein. (111 aa)
	CGAS	Cyclic GMP-AMP synthase. (522 aa)
	ENSMNEP00000045412	Uncharacterized protein. (188 aa)
	CXCL10	C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	DDX58	ENSMNEP00000014168	ENSMNEP00000037653	Adenosine deaminase RNA specific.	DExD/H-box helicase 58.	0.407
ADAR	IRF7	ENSMNEP00000014168	ENSMNEP00000009122	Adenosine deaminase RNA specific.	Interferon regulatory factor 7.	0.487
ADAR	ZBP1	ENSMNEP00000014168	ENSMNEP00000042463	Adenosine deaminase RNA specific.	Z-DNA binding protein 1.	0.406
AIM2	CGAS	ENSMNEP00000012916	ENSMNEP00000044671	Absent in melanoma 2.	Cyclic GMP-AMP synthase.	0.606
AIM2	IL18	ENSMNEP00000012916	ENSMNEP00000039965	Absent in melanoma 2.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.556
AIM2	IL1B	ENSMNEP00000012916	ENSMNEP00000033521	Absent in melanoma 2.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.560
AIM2	IRF3	ENSMNEP00000012916	ENSMNEP00000027938	Absent in melanoma 2.	Interferon regulatory factor 3.	0.485
AIM2	PYCARD	ENSMNEP00000012916	ENSMNEP00000036486	Absent in melanoma 2.	PYD and CARD domain containing.	0.983
AIM2	STING1	ENSMNEP00000012916	ENSMNEP00000032068	Absent in melanoma 2.	Transmembrane protein 173.	0.532
AIM2	TBK1	ENSMNEP00000012916	ENSMNEP00000040919	Absent in melanoma 2.	TANK binding kinase 1.	0.472
CCL5	CXCL10	ENSMNEP00000021616	ENSMNEP00000046238	C-C motif chemokine.	C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	0.988
CCL5	ENSMNEP00000013537	ENSMNEP00000021616	ENSMNEP00000013537	C-C motif chemokine.	C-C motif chemokine.	0.706
CCL5	IL18	ENSMNEP00000021616	ENSMNEP00000039965	C-C motif chemokine.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.581
CCL5	IL1B	ENSMNEP00000021616	ENSMNEP00000033521	C-C motif chemokine.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.726
CCL5	IL6	ENSMNEP00000021616	ENSMNEP00000000727	C-C motif chemokine.	Interleukin 6.	0.753
CCL5	IRF3	ENSMNEP00000021616	ENSMNEP00000027938	C-C motif chemokine.	Interferon regulatory factor 3.	0.536
CCL5	IRF7	ENSMNEP00000021616	ENSMNEP00000009122	C-C motif chemokine.	Interferon regulatory factor 7.	0.523
CCL5	LOC105485102	ENSMNEP00000021616	ENSMNEP00000034005	C-C motif chemokine.	C-C motif chemokine.	0.702
CCL5	NFKB1	ENSMNEP00000021616	ENSMNEP00000010935	C-C motif chemokine.	Nuclear factor kappa B subunit 1.	0.946
CCL5	RELA	ENSMNEP00000021616	ENSMNEP00000028444	C-C motif chemokine.	RELA proto-oncogene, NF-kB subunit.	0.928