STRINGSTRING
IL2 IL2 LSP1 LSP1 CSDE1 CSDE1 MAPK14 MAPK14 KRAS KRAS PAK1 PAK1 NRAS NRAS MAPKAPK2 MAPKAPK2 CALM1 CALM1 IL12A IL12A NLRP3 NLRP3 REM1 REM1 CLEC1B CLEC1B PPP3R1 PPP3R1 CEACAM1 CEACAM1 MAPK10 MAPK10 PPP3CC PPP3CC EFCAB3 EFCAB3 MAPK12 MAPK12 GEM GEM AKT3 AKT3 PIK3R3 PIK3R3 RHOA RHOA EGR2 EGR2 RRAD RRAD CEACAM4 CEACAM4 IKBKE IKBKE IL10 IL10 MAPK9 MAPK9 MDM2 MDM2 PYCARD PYCARD BCL10 BCL10 LOC105495284 LOC105495284 MALT1 MALT1 TMEM52B TMEM52B MAPK13 MAPK13 CLEC7A CLEC7A RAF1 RAF1 RRAS2 RRAS2 CEACAM8 CEACAM8 IKBKB IKBKB IL1B IL1B CASP8 CASP8 NFKBIA NFKBIA PLK3 PLK3 HRAS HRAS PRKCD PRKCD PIK3CD PIK3CD PIK3R1 PIK3R1 CALM3 CALM3 CEACAM7 CEACAM7 TNF TNF AKT2 AKT2 SYK SYK RELA RELA ENSMNEP00000027695 ENSMNEP00000027695 PPP3CA PPP3CA CALM2 CALM2 RHOC RHOC RELB RELB ITPR3 ITPR3 AKT1 AKT1 IL23A IL23A CLEC4D CLEC4D CALML6 CALML6 LOC105495621 LOC105495621 EGR3 EGR3 PVALEF PVALEF ITPR1 ITPR1 CBLB CBLB CLEC4E CLEC4E BCL3 BCL3 LOC105495257 LOC105495257 NFATC2 NFATC2 FCER1G FCER1G CLEC1A CLEC1A CLEC4A CLEC4A STAT2 STAT2 ENSMNEP00000020329 ENSMNEP00000020329 PIK3CA PIK3CA IL17D IL17D IL12B IL12B ARHGEF12 ARHGEF12 PTGS2 PTGS2 CALML4 CALML4 CD209 CD209 PPP3CB PPP3CB PLK5 PLK5 CCL17 CCL17 ENSMNEP00000017586 ENSMNEP00000017586 CCL22 CCL22 RRAS RRAS CLEC4G CLEC4G ENSMNEP00000016414 ENSMNEP00000016414 IRF1 IRF1 MAPK3 MAPK3 IRF9 IRF9 CLEC6A CLEC6A LOC105495285 LOC105495285 ENSMNEP00000013536 ENSMNEP00000013536 CARD9 CARD9 MAPK8 MAPK8 CHUK CHUK ENSMNEP00000012679 ENSMNEP00000012679 NFATC4 NFATC4 CYLD CYLD MAPK11 MAPK11 MAPK1 MAPK1 NFKB2 NFKB2 NFKB1 NFKB1 MRAS MRAS KSR1 KSR1 PIK3R2 PIK3R2 CEACAM16 CEACAM16 CLEC9A CLEC9A SRC SRC ENSMNEP00000005419 ENSMNEP00000005419 NFATC3 NFATC3 ITPR2 ITPR2 PTPN11 PTPN11 MAP3K14 MAP3K14 NFATC1 NFATC1 PLCG2 PLCG2 CALML3 CALML3 ENSMNEP00000001187 ENSMNEP00000001187 STAT1 STAT1 ERAS ERAS ENSMNEP00000000774 ENSMNEP00000000774 IL6 IL6 ENSMNEP00000000584 ENSMNEP00000000584 PIK3CB PIK3CB IKBKG IKBKG EFCAB13 EFCAB13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
LSP1Lymphocyte specific protein 1. (454 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
CALM1Calmodulin 1. (149 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
CLEC1BC-type lectin domain family 1 member B. (229 aa)
PPP3R1Uncharacterized protein. (189 aa)
CEACAM1Uncharacterized protein. (544 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
EFCAB3EF-hand calcium binding domain 3. (488 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
RHOARas homolog family member A. (193 aa)
EGR2Early growth response 2. (426 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
CEACAM4Carcinoembryonic antigen related cell adhesion molecule 4. (254 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
PYCARDPYD and CARD domain containing. (195 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
LOC105495284IGv domain-containing protein. (252 aa)
MALT1MALT1 paracaspase. (824 aa)
TMEM52BTransmembrane protein 52B. (191 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
RRAS2RAS related 2. (204 aa)
CEACAM8Carcinoembryonic antigen related cell adhesion molecule 8. (349 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (487 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PLK3Serine/threonine-protein kinase PLK. (608 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PRKCDProtein kinase C. (729 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CALM3Calmodulin 3. (149 aa)
CEACAM7Carcinoembryonic antigen related cell adhesion molecule 7. (264 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SYKTyrosine-protein kinase. (629 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
ENSMNEP00000027695Uncharacterized protein. (445 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
RHOCRas homolog family member C. (193 aa)
RELBRELB proto-oncogene, NF-kB subunit. (547 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
CLEC4DC-type lectin domain family 4 member D. (215 aa)
CALML6Calmodulin like 6. (181 aa)
LOC105495621Uncharacterized protein. (346 aa)
EGR3Early growth response 3. (387 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
CBLBCbl proto-oncogene B. (961 aa)
CLEC4EC-type lectin domain family 4 member E. (219 aa)
BCL3BCL3 transcription coactivator. (454 aa)
LOC105495257Uncharacterized protein. (456 aa)
NFATC2Nuclear factor of activated T cells 2. (921 aa)
FCER1GFc fragment of IgE receptor Ig. (112 aa)
CLEC1AC-type lectin domain family 1 member A. (280 aa)
CLEC4AC-type lectin domain family 4 member A. (237 aa)
STAT2Signal transducer and activator of transcription. (852 aa)
ENSMNEP00000020329IGv domain-containing protein. (125 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL17DInterleukin 17D. (202 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1484 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CALML4Calmodulin like 4. (193 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (413 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PLK5Polo like kinase 5. (299 aa)
CCL17C-C motif chemokine. (91 aa)
ENSMNEP00000017586Ig-like domain-containing protein. (234 aa)
CCL22C-C motif chemokine ligand 22. (93 aa)
RRASRAS related. (218 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
ENSMNEP00000016414Uncharacterized protein; Belongs to the calmodulin family. (179 aa)
IRF1Interferon regulatory factor. (325 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IRF9Interferon regulatory factor 9. (392 aa)
CLEC6AC-type lectin domain containing 6A. (209 aa)
LOC105495285Uncharacterized protein. (344 aa)
ENSMNEP00000013536Uncharacterized protein. (426 aa)
CARD9Caspase recruitment domain family member 9. (535 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSMNEP00000012679Uncharacterized protein. (262 aa)
NFATC4Nuclear factor of activated T cells 4. (961 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
KSR1Kinase suppressor of ras 1. (932 aa)
PIK3R2Uncharacterized protein. (668 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (452 aa)
CLEC9AC-type lectin domain containing 9A. (295 aa)
SRCTyrosine-protein kinase. (644 aa)
ENSMNEP00000005419Uncharacterized protein. (114 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
NFATC1Nuclear factor of activated T cells 1. (988 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ENSMNEP00000001187Uncharacterized protein. (333 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
ERASES cell expressed Ras. (233 aa)
ENSMNEP00000000774Uncharacterized protein. (378 aa)
IL6Interleukin 6. (214 aa)
ENSMNEP00000000584Uncharacterized protein. (304 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa)
EFCAB13EF-hand calcium binding domain 13. (925 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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