STRINGSTRING
ENSMNEP00000028956 ENSMNEP00000028956 PRKCG PRKCG PRKCA PRKCA SYK SYK ENSMNEP00000028225 ENSMNEP00000028225 KLRK1 KLRK1 ENSMNEP00000027902 ENSMNEP00000027902 ZAP70 ZAP70 ENSMNEP00000027695 ENSMNEP00000027695 CSF2 CSF2 PPP3CA PPP3CA GRB2 GRB2 LOC105497646 LOC105497646 LCK LCK SHC3 SHC3 ULBP1 ULBP1 ENSMNEP00000025520 ENSMNEP00000025520 SH2D1A SH2D1A VAV2 VAV2 TNFRSF10B TNFRSF10B SHC4 SHC4 ENSMNEP00000023427 ENSMNEP00000023427 LAT LAT IFNGR2 IFNGR2 NFATC2 NFATC2 FCER1G FCER1G ENSMNEP00000021289 ENSMNEP00000021289 TNFRSF10A TNFRSF10A ENSMNEP00000020833 ENSMNEP00000020833 SH3BP2 SH3BP2 PIK3CA PIK3CA ENSMNEP00000020180 ENSMNEP00000020180 ENSMNEP00000019904 ENSMNEP00000019904 VAV1 VAV1 CEP152 CEP152 ENSMNEP00000019155 ENSMNEP00000019155 RAC2 RAC2 ENSMNEP00000018955 ENSMNEP00000018955 ENSMNEP00000018934 ENSMNEP00000018934 KIR3DL3 KIR3DL3 ICAM1 ICAM1 PTK2B PTK2B PPP3CB PPP3CB ARAF ARAF ENSMNEP00000016378 ENSMNEP00000016378 BID BID MAPK3 MAPK3 ENSMNEP00000014001 ENSMNEP00000014001 ITGB2 ITGB2 PIK3CB PIK3CB ENSMNEP00000000821 ENSMNEP00000000821 ERAS ERAS IFNA6 IFNA6 ENSMNEP00000001351 ENSMNEP00000001351 ENSMNEP00000002263 ENSMNEP00000002263 PLCG2 PLCG2 NFATC1 NFATC1 ENSMNEP00000004019 ENSMNEP00000004019 PTPN11 PTPN11 LOC105489026 LOC105489026 SRMS SRMS PRF1 PRF1 LOC105492342 LOC105492342 BRAF BRAF PRKCB PRKCB MAP2K1 MAP2K1 ENSMNEP00000006342 ENSMNEP00000006342 SOS2 SOS2 ENSMNEP00000006768 ENSMNEP00000006768 FAS FAS HCST HCST PTK6 PTK6 PIK3R2 PIK3R2 RAC3 RAC3 FYN FYN LOC105489025 LOC105489025 VAV3 VAV3 ENSMNEP00000010506 ENSMNEP00000010506 GZMB GZMB KLRG1 KLRG1 MAPK1 MAPK1 ENSMNEP00000011919 ENSMNEP00000011919 ENSMNEP00000012679 ENSMNEP00000012679 ENSMNEP00000013313 ENSMNEP00000013313 NCR1 NCR1 ENSMNEP00000037373 ENSMNEP00000037373 TYROBP TYROBP PIK3R3 PIK3R3 IFNGR1 IFNGR1 PLCG1 PLCG1 PPP3CC PPP3CC ENSMNEP00000040882 ENSMNEP00000040882 LOC105497655 LOC105497655 LOC105498430 LOC105498430 ITGAL ITGAL PPP3R1 PPP3R1 CD48 CD48 ENSMNEP00000041867 ENSMNEP00000041867 CD244 CD244 SOS1 SOS1 MAP2K2 MAP2K2 NCR3 NCR3 LOC105496985 LOC105496985 NCR2 NCR2 LOC105499937 LOC105499937 KLRD1 KLRD1 NRAS NRAS PAK1 PAK1 IFNG IFNG KRAS KRAS CSDE1 CSDE1 IFNA14 IFNA14 IFNAR2 IFNAR2 CD247 CD247 ENSMNEP00000036315 ENSMNEP00000036315 RAF1 RAF1 SHC2 SHC2 FASLG FASLG SHC1 SHC1 KLRC1 KLRC1 HRAS HRAS LOC105498220 LOC105498220 TNFSF10 TNFSF10 ICAM2 ICAM2 LCP2 LCP2 RAC1 RAC1 PIK3CD PIK3CD PIK3R1 PIK3R1 KIR2DL4 KIR2DL4 PTPN6 PTPN6 SH2D1B SH2D1B TREML4 TREML4 LOC105498418 LOC105498418 TNF TNF IFNB1 IFNB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMNEP00000028956Uncharacterized protein. (185 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SYKTyrosine-protein kinase. (629 aa)
ENSMNEP00000028225MHC_I-like_Ag-recog domain-containing protein. (198 aa)
KLRK1Killer cell lectin like receptor K1. (216 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
ENSMNEP00000027695Uncharacterized protein. (445 aa)
CSF2Colony stimulating factor 2. (144 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LOC105497646Ig-like domain-containing protein. (220 aa)
LCKTyrosine-protein kinase. (540 aa)
SHC3SHC adaptor protein 3. (598 aa)
ULBP1UL16 binding protein 1. (245 aa)
ENSMNEP00000025520Ig-like domain-containing protein. (194 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
TNFRSF10BTNF receptor superfamily member 10b. (445 aa)
SHC4SHC adaptor protein 4. (630 aa)
ENSMNEP00000023427Uncharacterized protein. (198 aa)
LATLinker for activation of T cells. (271 aa)
IFNGR2Interferon gamma receptor 2. (312 aa)
NFATC2Nuclear factor of activated T cells 2. (921 aa)
FCER1GFc fragment of IgE receptor Ig. (112 aa)
ENSMNEP00000021289Ig-like domain-containing protein. (182 aa)
TNFRSF10ATNF receptor superfamily member 10a. (309 aa)
ENSMNEP00000020833Ig-like domain-containing protein. (145 aa)
SH3BP2SH3 domain binding protein 2. (613 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSMNEP00000020180MHC_I-like_Ag-recog domain-containing protein. (229 aa)
ENSMNEP00000019904Uncharacterized protein. (308 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
CEP152Centrosomal protein 152. (1703 aa)
ENSMNEP00000019155Interfer-bind domain-containing protein. (338 aa)
RAC2Rac family small GTPase 2. (192 aa)
ENSMNEP00000018955Uncharacterized protein. (345 aa)
ENSMNEP00000018934MHC_I-like_Ag-recog domain-containing protein. (199 aa)
KIR3DL3Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3. (316 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
BIDBH3 interacting domain death agonist. (266 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSMNEP00000014001Uncharacterized protein. (457 aa)
ITGB2Integrin beta. (921 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ENSMNEP00000000821Ig-like domain-containing protein. (143 aa)
ERASES cell expressed Ras. (233 aa)
IFNA6Interferon alpha 6. (190 aa)
ENSMNEP00000001351Ig-like domain-containing protein. (151 aa)
ENSMNEP00000002263Uncharacterized protein. (329 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
NFATC1Nuclear factor of activated T cells 1. (988 aa)
ENSMNEP00000004019Uncharacterized protein; Belongs to the peptidase C14A family. (242 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
LOC105489026MHC_I-like_Ag-recog domain-containing protein. (249 aa)
SRMSTyrosine-protein kinase. (492 aa)
PRF1Perforin. (555 aa)
LOC105492342Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
ENSMNEP00000006342IG domain-containing protein. (154 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
ENSMNEP00000006768Uncharacterized protein. (236 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa)
HCSTHematopoietic cell signal transducer. (92 aa)
PTK6Tyrosine-protein kinase. (397 aa)
PIK3R2Uncharacterized protein. (668 aa)
RAC3Rac family small GTPase 3. (192 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC105489025MHC_I-like_Ag-recog domain-containing protein. (230 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
ENSMNEP00000010506Ig-like domain-containing protein. (142 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (281 aa)
KLRG1Killer cell lectin like receptor G1. (189 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSMNEP00000011919MHC_I-like_Ag-recog domain-containing protein. (259 aa)
ENSMNEP00000012679Uncharacterized protein. (262 aa)
ENSMNEP00000013313Uncharacterized protein. (152 aa)
NCR1Natural cytotoxicity triggering receptor 1. (270 aa)
ENSMNEP00000037373MHC_I-like_Ag-recog domain-containing protein. (232 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (144 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
ENSMNEP00000040882C-type lectin domain-containing protein. (239 aa)
LOC105497655Ig-like domain-containing protein. (390 aa)
LOC105498430Uncharacterized protein. (189 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1123 aa)
PPP3R1Uncharacterized protein. (189 aa)
CD48CD48 molecule. (240 aa)
ENSMNEP00000041867Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
CD244CD244 molecule. (367 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
NCR3Natural cytotoxicity triggering receptor 3. (176 aa)
LOC105496985Uncharacterized protein. (351 aa)
NCR2Natural cytotoxicity triggering receptor 2. (294 aa)
LOC105499937C-type lectin domain-containing protein. (284 aa)
KLRD1Killer cell lectin like receptor D1. (179 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CSDE1Cold shock domain containing E1. (844 aa)
IFNA14Interferon alpha 14. (137 aa)
IFNAR2Uncharacterized protein. (516 aa)
CD247CD247 molecule. (164 aa)
ENSMNEP00000036315Uncharacterized protein. (182 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SHC2Uncharacterized protein. (572 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
SHC1SHC adaptor protein 1. (584 aa)
KLRC1Killer cell lectin like receptor C1. (233 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC105498220Uncharacterized protein. (342 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
ICAM2Intercellular adhesion molecule 2. (275 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
RAC1Rac family small GTPase 1. (211 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
KIR2DL4Uncharacterized protein. (416 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
SH2D1BSH2 domain containing 1B. (132 aa)
TREML4Triggering receptor expressed on myeloid cells like 4. (202 aa)
LOC105498418Uncharacterized protein. (190 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IFNB1Interferon beta 1. (187 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (32%) [HD]