STRINGSTRING
MAPK14 MAPK14 IL17D IL17D CD3D CD3D STAT3 STAT3 CD3E CD3E SMAD3 SMAD3 PPP3CB PPP3CB HLA-DMA HLA-DMA STAT5B STAT5B STAT5A STAT5A IL4R IL4R MAPK3 MAPK3 DUSP15 DUSP15 ENSMNEP00000015253 ENSMNEP00000015253 TGFBR1 TGFBR1 FOS FOS ENSMNEP00000014831 ENSMNEP00000014831 JAK2 JAK2 IL2RG IL2RG IL21 IL21 SMAD4 SMAD4 MAPK8 MAPK8 CHUK CHUK MAPK11 MAPK11 MAPK1 MAPK1 NFKB1 NFKB1 HLA-DPB1 HLA-DPB1 IL22 IL22 ENSMNEP00000010486 ENSMNEP00000010486 RARA RARA IL1R1 IL1R1 MTOR MTOR RXRA RXRA ENSMNEP00000008684 ENSMNEP00000008684 PRKCQ PRKCQ NFATC3 NFATC3 IL12RB1 IL12RB1 LOC105470433 LOC105470433 RORA RORA ENSMNEP00000004521 ENSMNEP00000004521 HLA-DRA HLA-DRA NFATC1 NFATC1 ENSMNEP00000002245 ENSMNEP00000002245 FOXS1 FOXS1 HLA-DOA HLA-DOA JAK1 JAK1 ENSMNEP00000001232 ENSMNEP00000001232 STAT1 STAT1 IL6 IL6 IKBKG IKBKG IL2 IL2 ENSMNEP00000000010 ENSMNEP00000000010 IL4 IL4 RXRB RXRB HSP90AB1 HSP90AB1 NFATC2 NFATC2 HSP90AA1 HSP90AA1 IFNGR2 IFNGR2 IL6ST IL6ST LAT LAT FOXP3 FOXP3 IL23A IL23A TBX21 TBX21 RXRG RXRG LCK LCK IL1RAP IL1RAP PPP3CA PPP3CA AHR AHR ZAP70 ZAP70 SMAD2 SMAD2 RELA RELA IRF4 IRF4 ENSMNEP00000028604 ENSMNEP00000028604 TRAC TRAC HLA-DQA1 HLA-DQA1 IL17F IL17F TYK2 TYK2 CD3G CD3G NFKBIA NFKBIA IL1B IL1B IKBKB IKBKB TRAV22 TRAV22 JAK3 JAK3 MAPK13 MAPK13 IL2RA IL2RA HLA-DPA1 HLA-DPA1 IL17A IL17A TGFBR2 TGFBR2 RORC RORC CD247 CD247 IL23R IL23R IL21R IL21R MAPK9 MAPK9 ENSMNEP00000038155 ENSMNEP00000038155 ENSMNEP00000038649 ENSMNEP00000038649 IFNGR1 IFNGR1 MAPK12 MAPK12 PLCG1 PLCG1 IL2RB IL2RB TGFB1 TGFB1 PPP3CC PPP3CC CD4 CD4 MAPK10 MAPK10 HIF1A HIF1A HLA-DOB HLA-DOB PPP3R1 PPP3R1 LOC105474413 LOC105474413 GATA3 GATA3 LOC105474426 LOC105474426 IL6R IL6R IL27RA IL27RA NFKBIB NFKBIB RUNX1 RUNX1 IFNG IFNG STAT6 STAT6 LOC105470432 LOC105470432
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK14Mitogen-activated protein kinase. (360 aa)
IL17DInterleukin 17D. (202 aa)
CD3DCD3d molecule. (171 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
CD3ECD3e molecule. (198 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
STAT5BSignal transducer and activator of transcription. (783 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
IL4RInterleukin 4 receptor. (825 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
DUSP15Dual specificity phosphatase 15; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (258 aa)
ENSMNEP00000015253HATPase_c domain-containing protein. (688 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ENSMNEP00000014831HATPase_c domain-containing protein. (645 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (268 aa)
IL22Interleukin 22. (179 aa)
ENSMNEP00000010486Ig-like domain-containing protein. (133 aa)
RARARetinoic acid receptor alpha. (477 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
RXRARetinoid X receptor alpha. (523 aa)
ENSMNEP00000008684Uncharacterized protein. (389 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (678 aa)
LOC105470433MHC class II antigen. (260 aa)
RORARAR related orphan receptor A. (555 aa)
ENSMNEP00000004521Ig-like domain-containing protein. (230 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
NFATC1Nuclear factor of activated T cells 1. (988 aa)
ENSMNEP00000002245Ig-like domain-containing protein. (232 aa)
FOXS1Forkhead box S1. (330 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
ENSMNEP00000001232Uncharacterized protein. (117 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
IL6Interleukin 6. (214 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
ENSMNEP00000000010Uncharacterized protein. (141 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
RXRBRetinoid X receptor beta. (537 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
NFATC2Nuclear factor of activated T cells 2. (921 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (823 aa)
IFNGR2Interferon gamma receptor 2. (312 aa)
IL6STInterleukin 6 signal transducer. (942 aa)
LATLinker for activation of T cells. (271 aa)
FOXP3Forkhead box P3. (456 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
TBX21T-box transcription factor 21. (535 aa)
RXRGRetinoid X receptor gamma. (463 aa)
LCKTyrosine-protein kinase. (540 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
AHRUncharacterized protein. (848 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
IRF4Interferon regulatory factor 4. (451 aa)
ENSMNEP00000028604IGv domain-containing protein. (139 aa)
TRACT cell receptor alpha constant. (110 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (267 aa)
IL17FInterleukin 17F. (163 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
CD3GCD3g molecule. (209 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TRAV22T cell receptor alpha variable 22. (147 aa)
JAK3Tyrosine-protein kinase. (1088 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
IL17AInterleukin 17A. (155 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RORCRAR related orphan receptor C. (518 aa)
CD247CD247 molecule. (164 aa)
IL23RInterleukin 23 receptor. (576 aa)
IL21RInterleukin 21 receptor. (538 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
ENSMNEP00000038155Uncharacterized protein. (314 aa)
ENSMNEP00000038649Ig-like domain-containing protein. (235 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (285 aa)
PPP3R1Uncharacterized protein. (189 aa)
LOC105474413Ig-like domain-containing protein. (295 aa)
GATA3GATA binding protein 3. (444 aa)
LOC105474426Ig-like domain-containing protein. (263 aa)
IL6RInterleukin 6 receptor. (467 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
LOC105470432Ig-like domain-containing protein; Belongs to the MHC class II family. (260 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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