STRINGSTRING
CBLB CBLB PPP3CC PPP3CC PLCG1 PLCG1 MAPK12 MAPK12 AKT3 AKT3 PIK3R3 PIK3R3 RHOA RHOA IL10 IL10 MAPK9 MAPK9 CD247 CD247 BCL10 BCL10 MALT1 MALT1 MAPK13 MAPK13 RAF1 RAF1 TRAV22 TRAV22 IKBKB IKBKB PAK3 PAK3 NFKBIA NFKBIA MAP3K7 MAP3K7 HRAS HRAS CD40LG CD40LG LCP2 LCP2 NCK2 NCK2 PIK3CD PIK3CD CD3G CD3G PIK3R1 PIK3R1 TRAC TRAC PTPN6 PTPN6 TNF TNF ENSMNEP00000029022 ENSMNEP00000029022 AKT2 AKT2 ENSMNEP00000028604 ENSMNEP00000028604 RELA RELA ENSMNEP00000027902 ENSMNEP00000027902 ZAP70 ZAP70 CSF2 CSF2 PPP3CA PPP3CA GRB2 GRB2 RHOC RHOC LCK LCK AKT1 AKT1 NCK1 NCK1 VAV2 VAV2 MAP2K7 MAP2K7 CD4 CD4 MAPK10 MAPK10 PPP3R1 PPP3R1 CTLA4 CTLA4 SOS1 SOS1 MAP2K2 MAP2K2 GRAP2 GRAP2 DLG1 DLG1 NFKBIB NFKBIB NRAS NRAS PAK1 PAK1 PAK6 PAK6 IFNG IFNG ENSMNEP00000045127 ENSMNEP00000045127 KRAS KRAS MAPK14 MAPK14 CSDE1 CSDE1 PDPK1 PDPK1 ENSMNEP00000000010 ENSMNEP00000000010 IL2 IL2 IKBKG IKBKG PIK3CB PIK3CB CARD11 CARD11 ERAS ERAS IL5 IL5 ITK ITK NFATC1 NFATC1 MAP3K14 MAP3K14 PAK2 PAK2 ENSMNEP00000004647 ENSMNEP00000004647 SRMS SRMS NFATC3 NFATC3 ENSMNEP00000005419 ENSMNEP00000005419 GSK3B GSK3B MAP2K1 MAP2K1 PAK5 PAK5 SOS2 SOS2 PRKCQ PRKCQ PTK6 PTK6 PIK3R2 PIK3R2 FYN FYN CD8A CD8A VAV3 VAV3 ICOS ICOS ENSMNEP00000010486 ENSMNEP00000010486 NFKB1 NFKB1 CD8B CD8B ENSMNEP00000011554 ENSMNEP00000011554 MAPK1 MAPK1 MAPK11 MAPK11 PTPRC PTPRC CHUK CHUK MAPK8 MAPK8 TEC TEC FOS FOS MAPK3 MAPK3 CDK4 CDK4 PAK4 PAK4 MAP3K8 MAP3K8 PPP3CB PPP3CB RASGRP1 RASGRP1 CD3E CD3E CD3D CD3D CD28 CD28 VAV1 VAV1 IL4 IL4 PIK3CA PIK3CA PDCD1 PDCD1 CDC42 CDC42 NFATC2 NFATC2 LAT LAT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBLBCbl proto-oncogene B. (961 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
RHOARas homolog family member A. (193 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
CD247CD247 molecule. (164 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
MALT1MALT1 paracaspase. (824 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
TRAV22T cell receptor alpha variable 22. (147 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
NCK2Cytoplasmic protein. (382 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CD3GCD3g molecule. (209 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TRACT cell receptor alpha constant. (110 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ENSMNEP00000029022Uncharacterized protein. (185 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSMNEP00000028604IGv domain-containing protein. (139 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
CSF2Colony stimulating factor 2. (144 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RHOCRas homolog family member C. (193 aa)
LCKTyrosine-protein kinase. (540 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NCK1Cytoplasmic protein. (377 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (384 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
PPP3R1Uncharacterized protein. (189 aa)
CTLA4CD152 protein. (223 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (947 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
ENSMNEP00000045127Uncharacterized protein. (183 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (582 aa)
ENSMNEP00000000010Uncharacterized protein. (141 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
ERASES cell expressed Ras. (233 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
ITKTyrosine-protein kinase. (620 aa)
NFATC1Nuclear factor of activated T cells 1. (988 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
PAK2Non-specific serine/threonine protein kinase. (501 aa)
ENSMNEP00000004647Uncharacterized protein. (185 aa)
SRMSTyrosine-protein kinase. (492 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
ENSMNEP00000005419Uncharacterized protein. (114 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PTK6Tyrosine-protein kinase. (397 aa)
PIK3R2Uncharacterized protein. (668 aa)
FYNTyrosine-protein kinase. (537 aa)
CD8ACD8a molecule. (253 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
ICOSInducible T cell costimulator. (199 aa)
ENSMNEP00000010486Ig-like domain-containing protein. (133 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
CD8BIg-like domain-containing protein. (243 aa)
ENSMNEP00000011554Uncharacterized protein. (157 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TECTyrosine-protein kinase. (630 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (260 aa)
PAK4Non-specific serine/threonine protein kinase. (702 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (572 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
RASGRP1RAS guanyl releasing protein 1. (832 aa)
CD3ECD3e molecule. (198 aa)
CD3DCD3d molecule. (171 aa)
CD28CD28 molecule. (220 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDCD1Programmed cell death 1. (288 aa)
CDC42Uncharacterized protein. (191 aa)
NFATC2Nuclear factor of activated T cells 2. (921 aa)
LATLinker for activation of T cells. (271 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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