STRINGSTRING
IKBKG IKBKG PIK3CB PIK3CB IL6 IL6 DAB2IP DAB2IP JUNB JUNB SOCS3 SOCS3 TRAF3 TRAF3 CEBPB CEBPB MAP3K14 MAP3K14 TAB2 TAB2 TRADD TRADD ENSMNEP00000004019 ENSMNEP00000004019 TRAF2 TRAF2 LOC105492342 LOC105492342 MMP10 MMP10 RFWD3 RFWD3 MAP2K1 MAP2K1 CEACAM16 CEACAM16 FAS FAS PIK3R2 PIK3R2 EDN1 EDN1 ATF6B ATF6B LOC105477295 LOC105477295 ITCH ITCH RIPK1 RIPK1 NFKB1 NFKB1 LOC105471157 LOC105471157 TNFRSF1A TNFRSF1A MAPK1 MAPK1 MAPK11 MAPK11 CREB1 CREB1 CHUK CHUK MMP14 MMP14 MAPK8 MAPK8 RIPK3 RIPK3 FOS FOS LOC105477292 LOC105477292 MAPK3 MAPK3 CXCL1 CXCL1 RPS6KA4 RPS6KA4 PGAM5 PGAM5 IRF1 IRF1 NOD2 NOD2 SELE SELE MAP3K8 MAP3K8 MAP2K3 MAP2K3 ICAM1 ICAM1 LOC105477289 LOC105477289 CX3CL1 CX3CL1 CCDC88B CCDC88B PTGS2 PTGS2 PIK3CA PIK3CA CREB5 CREB5 CCL5 CCL5 BCL3 BCL3 MMP9 MMP9 VCAM1 VCAM1 BAG4 BAG4 MAP2K7 MAP2K7 MAP2K4 MAP2K4 TNFRSF1B TNFRSF1B CXCL6 CXCL6 TNFAIP3 TNFAIP3 CASP7 CASP7 AKT1 AKT1 MAP2K6 MAP2K6 CASP10 CASP10 CSF2 CSF2 ENSMNEP00000027902 ENSMNEP00000027902 DNM1L DNM1L ATF4 ATF4 RELA RELA CSF1 CSF1 VEGFD VEGFD AKT2 AKT2 IFNB1 IFNB1 RPS6KA5 RPS6KA5 FADD FADD ATF2 ATF2 BIRC2 BIRC2 TNF TNF JAG1 JAG1 TAB3 TAB3 LIF LIF PIK3R1 PIK3R1 CCL2 CCL2 PIK3CD PIK3CD TRAF5 TRAF5 MAP3K7 MAP3K7 NFKBIA NFKBIA LTA LTA CREB3L3 CREB3L3 CASP8 CASP8 IL1B IL1B IKBKB IKBKB IL15 IL15 BIRC3 BIRC3 CREB3L2 CREB3L2 MAPK13 MAPK13 CREB3L1 CREB3L1 MAPK9 MAPK9 CCL20 CCL20 PIK3R3 PIK3R3 IL18R1 IL18R1 TAB1 TAB1 AKT3 AKT3 MLKL MLKL MAPK12 MAPK12 CREB3L4 CREB3L4 MAP3K5 MAP3K5 MAPK10 MAPK10 MMP3 MMP3 CFLAR CFLAR ENSMNEP00000041867 ENSMNEP00000041867 TRAF1 TRAF1 CREB3 CREB3 VEGFC VEGFC MAPK14 MAPK14 CXCL10 CXCL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
IL6Interleukin 6. (214 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
ENSMNEP00000004019Uncharacterized protein; Belongs to the peptidase C14A family. (242 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
LOC105492342Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
MMP10Matrix metallopeptidase 10. (475 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (452 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa)
PIK3R2Uncharacterized protein. (668 aa)
EDN1Endothelin 1. (211 aa)
ATF6BActivating transcription factor 6 beta. (710 aa)
LOC105477295C-X-C motif chemokine. (114 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (693 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
LOC105471157C-X-C motif chemokine. (103 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LOC105477292C-X-C motif chemokine. (154 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CXCL1C-X-C motif chemokine. (107 aa)
RPS6KA4Non-specific serine/threonine protein kinase. (649 aa)
PGAM5Uncharacterized protein. (140 aa)
IRF1Interferon regulatory factor. (325 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
SELESelectin E. (612 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (572 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
LOC105477289C-X-C motif chemokine. (114 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
CCDC88BCoiled-coil domain containing 88B. (1476 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
CCL5C-C motif chemokine. (91 aa)
BCL3BCL3 transcription coactivator. (454 aa)
MMP9Matrix metallopeptidase 9. (694 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (384 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (374 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
CXCL6C-X-C motif chemokine. (123 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (377 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (520 aa)
CSF2Colony stimulating factor 2. (144 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
ATF4Activating transcription factor 4. (351 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IFNB1Interferon beta 1. (187 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CCL2C-C motif chemokine. (99 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (446 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (487 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
CCL20C-C motif chemokine. (96 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MLKLMixed lineage kinase domain like pseudokinase. (436 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
ENSMNEP00000041867Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
TRAF1TNF receptor-associated factor. (416 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CXCL10C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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