STRINGSTRING
BAD BAD ENSMNEP00000000010 ENSMNEP00000000010 PIK3CB PIK3CB ERAS ERAS BDNF BDNF CALML3 CALML3 NTF4 NTF4 SH2B2 SH2B2 ZNF274 ZNF274 RPS6KA3 RPS6KA3 PLCG2 PLCG2 PTPN11 PTPN11 ENSMNEP00000004647 ENSMNEP00000004647 IRAK2 IRAK2 IRAK1 IRAK1 ENSMNEP00000005419 ENSMNEP00000005419 BRAF BRAF GSK3B GSK3B MAP2K1 MAP2K1 SOS2 SOS2 BEX3 BEX3 ABL1 ABL1 RPS6KA2 RPS6KA2 PIK3R2 PIK3R2 RPS6KA6 RPS6KA6 ZFR ZFR NFKB1 NFKB1 RAPGEF1 RAPGEF1 NTRK2 NTRK2 ENSMNEP00000011545 ENSMNEP00000011545 ENSMNEP00000011554 ENSMNEP00000011554 MAPK1 MAPK1 MAPK11 MAPK11 ENSMNEP00000012002 ENSMNEP00000012002 ENSMNEP00000012679 ENSMNEP00000012679 MAPK8 MAPK8 CAMK4 CAMK4 RAP1A RAP1A SH2B3 SH2B3 MAGED1 MAGED1 ARHGDIB ARHGDIB MAPK3 MAPK3 ENSMNEP00000016333 ENSMNEP00000016333 ENSMNEP00000016378 ENSMNEP00000016378 ENSMNEP00000016414 ENSMNEP00000016414 PRDM4 PRDM4 GAB1 GAB1 IRAK3 IRAK3 CALML4 CALML4 CEP152 CEP152 ZSCAN1 ZSCAN1 CRKL CRKL ENSMNEP00000019824 ENSMNEP00000019824 PIK3CA PIK3CA SORT1 SORT1 CDC42 CDC42 NTRK3 NTRK3 GCNA GCNA CSK CSK BAX BAX BCL2 BCL2 SHC4 SHC4 MAP2K7 MAP2K7 FRS2 FRS2 PVALEF PVALEF CALML6 CALML6 TP73 TP73 PSEN2 PSEN2 ENSMNEP00000025369 ENSMNEP00000025369 SHC3 SHC3 AKT1 AKT1 RHOC RHOC CALM2 CALM2 GRB2 GRB2 NGF NGF ENSMNEP00000027695 ENSMNEP00000027695 PSEN1 PSEN1 ENSMNEP00000027902 ENSMNEP00000027902 ATF4 ATF4 MAP3K3 MAP3K3 RELA RELA ARHGDIA ARHGDIA AKT2 AKT2 ENSMNEP00000029022 ENSMNEP00000029022 RPS6KA5 RPS6KA5 CALM3 CALM3 PIK3R1 PIK3R1 TP53 TP53 PIK3CD PIK3CD RAC1 RAC1 PRKCD PRKCD MAP3K1 MAP3K1 HRAS HRAS CAMK2B CAMK2B ARSI ARSI CRK CRK NFKBIA NFKBIA IRAK4 IRAK4 IKBKB IKBKB FOXO3 FOXO3 NTF3 NTF3 SHC1 SHC1 FASLG FASLG SHC2 SHC2 RAF1 RAF1 MAPK13 MAPK13 RAP1B RAP1B MAPK7 MAPK7 CAMK2G CAMK2G MAPK9 MAPK9 RIPK2 RIPK2 IRS1 IRS1 TRAF6 TRAF6 RHOA RHOA PIK3R3 PIK3R3 AKT3 AKT3 MAPK12 MAPK12 ENSMNEP00000039571 ENSMNEP00000039571 PLCG1 PLCG1 MATK MATK SH2B1 SH2B1 YWHAE YWHAE MAP3K5 MAP3K5 MAPK10 MAPK10 RPS6KA1 RPS6KA1 NGFR NGFR ZFR2 ZFR2 NTRK1 NTRK1 MAP2K5 MAP2K5 CALM1 CALM1 SOS1 SOS1 MAP2K2 MAP2K2 MAPKAPK2 MAPKAPK2 CAMK2A CAMK2A KIDINS220 KIDINS220 NFKBIB NFKBIB NRAS NRAS ENSMNEP00000045127 ENSMNEP00000045127 KRAS KRAS MAPK14 MAPK14 CSDE1 CSDE1 PDPK1 PDPK1 ARHGDIG ARHGDIG PPP1R14B PPP1R14B CAMK2D CAMK2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BADBCL2 associated agonist of cell death. (167 aa)
ENSMNEP00000000010Uncharacterized protein. (141 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ERASES cell expressed Ras. (233 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
SH2B2SH2B adaptor protein 2. (680 aa)
ZNF274Zinc finger protein 274. (653 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ENSMNEP00000004647Uncharacterized protein. (185 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (717 aa)
ENSMNEP00000005419Uncharacterized protein. (114 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
BEX3Brain expressed X-linked 3. (123 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
RPS6KA2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (723 aa)
PIK3R2Uncharacterized protein. (668 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
ZFRZinc finger RNA binding protein. (1074 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ENSMNEP00000011545Uncharacterized protein. (81 aa)
ENSMNEP00000011554Uncharacterized protein. (157 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
ENSMNEP00000012679Uncharacterized protein. (262 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
SH2B3SH2B adaptor protein 3. (570 aa)
MAGED1MAGE family member D1. (834 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (201 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSMNEP0000001633314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (190 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
ENSMNEP00000016414Uncharacterized protein; Belongs to the calmodulin family. (179 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
CALML4Calmodulin like 4. (193 aa)
CEP152Centrosomal protein 152. (1703 aa)
ZSCAN1Zinc finger and SCAN domain containing 1. (398 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ENSMNEP00000019824Uncharacterized protein. (194 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SORT1Sortilin. (831 aa)
CDC42Uncharacterized protein. (191 aa)
NTRK3Tyrosine-protein kinase receptor. (866 aa)
GCNAGerm cell nuclear acidic peptidase. (672 aa)
CSKTyrosine-protein kinase. (450 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (384 aa)
FRS2Fibroblast growth factor receptor substrate 2. (515 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
CALML6Calmodulin like 6. (181 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
ENSMNEP00000025369Uncharacterized protein. (129 aa)
SHC3SHC adaptor protein 3. (598 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RHOCRas homolog family member C. (193 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
ENSMNEP00000027695Uncharacterized protein. (445 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
ATF4Activating transcription factor 4. (351 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (235 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSMNEP00000029022Uncharacterized protein. (185 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
CALM3Calmodulin 3. (149 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RAC1Rac family small GTPase 1. (211 aa)
PRKCDProtein kinase C. (729 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1345 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
ARSIArylsulfatase family member I. (569 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
FOXO3Forkhead box O3. (716 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
SHC1SHC adaptor protein 1. (584 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
SHC2Uncharacterized protein. (572 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
RAP1BUncharacterized protein. (137 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (813 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RHOARas homolog family member A. (193 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ENSMNEP00000039571Uncharacterized protein. (136 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MATKTyrosine-protein kinase. (539 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
NGFRNerve growth factor receptor. (439 aa)
ZFR2Zinc finger RNA binding protein 2. (908 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (472 aa)
CALM1Calmodulin 1. (149 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
KIDINS220Kinase D interacting substrate 220. (1771 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSMNEP00000045127Uncharacterized protein. (183 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (582 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (225 aa)
PPP1R14BUncharacterized protein. (208 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (12%) [HD]