STRINGSTRING
CACNA1C CACNA1C ENSMNEP00000013158 ENSMNEP00000013158 TRPC1 TRPC1 JMJD7 JMJD7 PELP1 PELP1 MAPK1 MAPK1 PLA2G4C PLA2G4C GABRB1 GABRB1 GNGT2 GNGT2 GNG2 GNG2 GNG10 GNG10 CYP2J2 CYP2J2 SLC6A4 SLC6A4 GNG8 GNG8 GABRB2 GABRB2 GNAQ GNAQ KCNJ5 KCNJ5 GNB2 GNB2 PLCB4 PLCB4 GNB4 GNB4 TPH1 TPH1 PLCB2 PLCB2 GNG7 GNG7 PLCB3 PLCB3 HTR2B HTR2B MAP2K1 MAP2K1 PRKCB PRKCB BRAF BRAF LOC105492342 LOC105492342 CACNA1S CACNA1S CYP4X1 CYP4X1 ENSMNEP00000005141 ENSMNEP00000005141 ITPR2 ITPR2 MAOA MAOA PLA2G4D PLA2G4D HTR2A HTR2A ENSMNEP00000004019 ENSMNEP00000004019 HTR1D HTR1D ENSMNEP00000002738 ENSMNEP00000002738 CACNA1F CACNA1F LOC105470207 LOC105470207 SLC18A2 SLC18A2 RAPGEF3 RAPGEF3 HTR1A HTR1A HTR1E HTR1E LOC105470210 LOC105470210 ERAS ERAS LOC105470579 LOC105470579 HTR1F HTR1F KCND2 KCND2 DDC DDC LOC105470206 LOC105470206 KCNN2 KCNN2 CACNA1A CACNA1A APP APP CSDE1 CSDE1 KRAS KRAS LOC105492507 LOC105492507 GNAO1 GNAO1 SLC18A1 SLC18A1 NRAS NRAS PLCB1 PLCB1 LOC105473037 LOC105473037 KCNJ9 KCNJ9 GNG4 GNG4 GNG12 GNG12 GNGT1 GNGT1 ENSMNEP00000041867 ENSMNEP00000041867 ADCY5 ADCY5 PRKACA PRKACA PTGS1 PTGS1 CACNA1B CACNA1B ALOX15B ALOX15B DUSP1 DUSP1 CYP2W1 CYP2W1 ALOX12B ALOX12B KCNJ3 KCNJ3 GNG14 GNG14 ENSMNEP00000038667 ENSMNEP00000038667 GNG13 GNG13 LOC105464350 LOC105464350 ENSMNEP00000037329 ENSMNEP00000037329 LOC105479949 LOC105479949 GNG3 GNG3 ALOX15 ALOX15 GNB5 GNB5 CACNA1D CACNA1D ALOX5 ALOX5 RAF1 RAF1 LOC105481168 LOC105481168 ENSMNEP00000034688 ENSMNEP00000034688 HRAS HRAS PRKACB PRKACB PLA2G4A PLA2G4A HTR6 HTR6 LOC105479916 LOC105479916 GNAI1 GNAI1 HTR7 HTR7 ENSMNEP00000029058 ENSMNEP00000029058 PRKCG PRKCG PRKCA PRKCA HTR1B HTR1B GNG5 GNG5 ENSMNEP00000027902 ENSMNEP00000027902 HTR5A HTR5A LOC105464352 LOC105464352 MAOB MAOB TPH2 TPH2 KCNJ6 KCNJ6 HTR3D HTR3D ITPR3 ITPR3 GNB3 GNB3 HTR3C HTR3C GNB1 GNB1 GNAI3 GNAI3 ITPR1 ITPR1 HTR4 HTR4 ALOX12 ALOX12 GABRB3 GABRB3 GNAS GNAS GNAI2 GNAI2 PTGS2 PTGS2 PLA2G4E PLA2G4E ARAF ARAF ENSMNEP00000016378 ENSMNEP00000016378 MAPK3 MAPK3 GNG11 GNG11 HTR3A HTR3A HTR3B HTR3B PLA2G4F PLA2G4F HTR2C HTR2C
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
ENSMNEP00000013158Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (793 aa)
JMJD7Jumonji domain containing 7. (364 aa)
PELP1Proline, glutamate and leucine rich protein 1. (1180 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
PLA2G4CPhospholipase A2 group IVC. (535 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CYP2J2Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
GNAQG protein subunit alpha q. (359 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (432 aa)
GNB2G protein subunit beta 2. (340 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
GNB4G protein subunit beta 4. (340 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1174 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
LOC105492342Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
CYP4X1Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (509 aa)
ENSMNEP00000005141Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
MAOAAmine oxidase. (527 aa)
PLA2G4DPhospholipase A2. (822 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
ENSMNEP00000004019Uncharacterized protein; Belongs to the peptidase C14A family. (242 aa)
HTR1D5-hydroxytryptamine receptor 1D. (377 aa)
ENSMNEP00000002738Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
LOC105470207Uncharacterized protein. (467 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (878 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
HTR1E5-hydroxytryptamine receptor 1E. (365 aa)
LOC105470210Uncharacterized protein; Belongs to the cytochrome P450 family. (489 aa)
ERASES cell expressed Ras. (233 aa)
LOC105470579Uncharacterized protein. (245 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
DDCDopa decarboxylase. (480 aa)
LOC105470206Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (844 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2497 aa)
APPAmyloid beta precursor protein. (770 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LOC105492507G_PROTEIN_RECEP_F1_2 domain-containing protein. (370 aa)
GNAO1G protein subunit alpha o1. (354 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC105473037Uncharacterized protein. (661 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (388 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ENSMNEP00000041867Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (632 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2340 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (676 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (490 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (701 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSMNEP00000038667Uncharacterized protein. (459 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
LOC105464350Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
ENSMNEP00000037329Phospholipase A2. (781 aa)
LOC105479949Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
GNB5G protein subunit beta 5. (409 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
LOC105481168Uncharacterized protein; Belongs to the cytochrome P450 family. (329 aa)
ENSMNEP00000034688Uncharacterized protein. (288 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PLA2G4APhospholipase A2. (749 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
LOC105479916Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
GNAI1G protein subunit alpha i1. (422 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (480 aa)
ENSMNEP00000029058Uncharacterized protein. (98 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
HTR5A5-hydroxytryptamine receptor 5A. (357 aa)
LOC105464352Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
MAOBAmine oxidase. (520 aa)
TPH2Tryptophan hydroxylase 2. (490 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
HTR3D5-hydroxytryptamine receptor 3D. (446 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
GNB3G protein subunit beta 3. (340 aa)
HTR3C5-hydroxytryptamine receptor 3C; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (426 aa)
GNB1G protein subunit beta 1. (340 aa)
GNAI3G protein subunit alpha i3. (328 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (428 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (529 aa)
GNASGNAS complex locus. (1007 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PLA2G4EPhospholipase A2. (869 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (515 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (420 aa)
PLA2G4FPhospholipase A2. (849 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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