STRINGSTRING
DRD3 DRD3 CACNA1A CACNA1A CAMK2D CAMK2D MAPK14 MAPK14 GNAO1 GNAO1 SLC18A1 SLC18A1 PLCB1 PLCB1 KCNJ9 KCNJ9 GNG4 GNG4 GNG12 GNG12 CAMK2A CAMK2A ARNTL ARNTL CREB3 CREB3 CALM1 CALM1 PPP2R5A PPP2R5A GNGT1 GNGT1 ADCY5 ADCY5 PPP2CA PPP2CA PRKACA PRKACA CACNA1B CACNA1B MAPK10 MAPK10 PPP3CC PPP3CC PPP2CB PPP2CB CREB3L4 CREB3L4 MAPK12 MAPK12 AKT3 AKT3 KCNJ3 KCNJ3 GNG14 GNG14 PPP1CA PPP1CA GNG13 GNG13 DRD2 DRD2 MAPK9 MAPK9 CREB3L1 CREB3L1 CAMK2G CAMK2G PPP2R2D PPP2R2D GNG3 GNG3 PPP1R1B PPP1R1B GNB5 GNB5 CACNA1D CACNA1D ARRB1 ARRB1 MAPK13 MAPK13 CREB3L2 CREB3L2 ENSMNEP00000034688 ENSMNEP00000034688 GRIA1 GRIA1 KIF5B KIF5B GRIA4 GRIA4 CREB3L3 CREB3L3 ARSI ARSI CAMK2B CAMK2B CALY CALY PRKACB PRKACB PPP1CC PPP1CC GNAI1 GNAI1 ENSMNEP00000030648 ENSMNEP00000030648 GRIN2A GRIN2A SCN1A SCN1A GSK3A GSK3A CALM3 CALM3 ATF2 ATF2 PPP2R5B PPP2R5B AKT2 AKT2 PRKCG PRKCG PPP2R5E PPP2R5E PRKCA PRKCA ATF4 ATF4 GNG5 GNG5 TH TH MAOB MAOB PPP3CA PPP3CA CALM2 CALM2 KCNJ6 KCNJ6 ITPR3 ITPR3 GNB3 GNB3 AKT1 AKT1 GNB1 GNB1 PPP2R1B PPP2R1B KIF5A KIF5A GNAI3 GNAI3 CALML6 CALML6 PVALEF PVALEF ITPR1 ITPR1 PPP2R5C PPP2R5C GNAS GNAS PPP2R1A PPP2R1A PPP2R5D PPP2R5D CREB5 CREB5 GNAI2 GNAI2 PPP2R3A PPP2R3A SLC6A3 SLC6A3 CALML4 CALML4 GNAL GNAL GRIA3 GRIA3 PPP3CB PPP3CB PPP1CB PPP1CB ENSMNEP00000016414 ENSMNEP00000016414 GNG11 GNG11 PPP2R2C PPP2R2C FOS FOS CLOCK CLOCK PPP2R2B PPP2R2B ENSMNEP00000013845 ENSMNEP00000013845 GRIN2B GRIN2B CACNA1C CACNA1C ENSMNEP00000013158 ENSMNEP00000013158 MAPK8 MAPK8 ARR3 ARR3 CREB1 CREB1 MAPK11 MAPK11 DRD4 DRD4 LOC105468691 LOC105468691 GNGT2 GNGT2 GNG2 GNG2 GNG10 GNG10 GNG8 GNG8 GNAQ GNAQ KCNJ5 KCNJ5 GNB2 GNB2 PLCB4 PLCB4 ATF6B ATF6B GNB4 GNB4 PLCB2 PLCB2 GNG7 GNG7 PLCB3 PLCB3 GSK3B GSK3B PRKCB PRKCB PPP2R3C PPP2R3C KIF5C KIF5C PPP2R2A PPP2R2A ENSMNEP00000005141 ENSMNEP00000005141 COMT COMT ITPR2 ITPR2 MAOA MAOA GRIA2 GRIA2 DRD5 DRD5 ENSMNEP00000002738 ENSMNEP00000002738 DRD1 DRD1 SLC18A2 SLC18A2 CALML3 CALML3 ARRB2 ARRB2 LOC105470579 LOC105470579 DDC DDC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (400 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2497 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GNAO1G protein subunit alpha o1. (354 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (388 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (628 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CALM1Calmodulin 1. (149 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2340 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
GNB5G protein subunit beta 5. (409 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
ARRB1Arrestin beta 1. (443 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ENSMNEP00000034688Uncharacterized protein. (288 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (893 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (446 aa)
ARSIArylsulfatase family member I. (569 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
CALYCalcyon neuron specific vesicular protein. (217 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
GNAI1G protein subunit alpha i1. (422 aa)
ENSMNEP00000030648EF-hand domain-containing protein. (559 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
CALM3Calmodulin 3. (149 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (596 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ATF4Activating transcription factor 4. (351 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
THTyrosine hydroxylase. (529 aa)
MAOBAmine oxidase. (520 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
GNB3G protein subunit beta 3. (340 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNB1G protein subunit beta 1. (340 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1021 aa)
GNAI3G protein subunit alpha i3. (328 aa)
CALML6Calmodulin like 6. (181 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (533 aa)
GNASGNAS complex locus. (1007 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1127 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
CALML4Calmodulin like 4. (193 aa)
GNALG protein subunit alpha L. (447 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ENSMNEP00000016414Uncharacterized protein; Belongs to the calmodulin family. (179 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CLOCKClock circadian regulator. (851 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
ENSMNEP00000013845Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (436 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
ENSMNEP00000013158Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ARR3Arrestin 3. (389 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (380 aa)
LOC105468691Uncharacterized protein. (270 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNAQG protein subunit alpha q. (359 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (432 aa)
GNB2G protein subunit beta 2. (340 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ATF6BActivating transcription factor 6 beta. (710 aa)
GNB4G protein subunit beta 4. (340 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1174 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (958 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
ENSMNEP00000005141Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (221 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
MAOAAmine oxidase. (527 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (478 aa)
ENSMNEP00000002738Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ARRB2Arrestin beta 2. (454 aa)
LOC105470579Uncharacterized protein. (245 aa)
DDCDopa decarboxylase. (480 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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