STRINGSTRING
PYGL PYGL PPP1R14B PPP1R14B PDPK1 PDPK1 CSDE1 CSDE1 KRAS KRAS RPS6KB1 RPS6KB1 PDE3B PDE3B NRAS NRAS ACACB ACACB MYO9B MYO9B BAD BAD TSC2 TSC2 TBCA TBCA MAP2K2 MAP2K2 SOS1 SOS1 CALM1 CALM1 FLOT2 FLOT2 PRKAR1A PRKAR1A REM1 REM1 ACACA ACACA GYS1 GYS1 PRKACA PRKACA MAPK10 MAPK10 PRKCI PRKCI SH2B1 SH2B1 EFCAB3 EFCAB3 GEM GEM LOC105487991 LOC105487991 AKT3 AKT3 IRS4 IRS4 PIK3R3 PIK3R3 PPP1CA PPP1CA RHEB RHEB IRS1 IRS1 RRAD RRAD KIAA1671 KIAA1671 CRYGN CRYGN MAPK9 MAPK9 HKDC1 HKDC1 SREBF2 SREBF2 ENSMNEP00000036225 ENSMNEP00000036225 PHKB PHKB BMT2 BMT2 RAF1 RAF1 SHC2 SHC2 PPP1R3C PPP1R3C SHC1 SHC1 LIPE LIPE ELK3 ELK3 IKBKB IKBKB CRK CRK PHKA2 PHKA2 ENSMNEP00000032306 ENSMNEP00000032306 HRAS HRAS PHKA1 PHKA1 PRKAR2B PRKAR2B PRKACB PRKACB RHOQ RHOQ PCK1 PCK1 PPP1CC PPP1CC PIK3CD PIK3CD PIK3R1 PIK3R1 SORBS3 SORBS3 EIF4E2 EIF4E2 PRKAG2 PRKAG2 CALM3 CALM3 FASN FASN PRKCZ PRKCZ AKT2 AKT2 FLOT1 FLOT1 GYS2 GYS2 MKNK1 MKNK1 PRKAG3 PRKAG3 ENSMNEP00000027902 ENSMNEP00000027902 PTPN1 PTPN1 TSC1 TSC1 SORBS2 SORBS2 GRB2 GRB2 GCK GCK PTPRD PTPRD CALM2 CALM2 BUD23 BUD23 AKT1 AKT1 INS INS SHC3 SHC3 PRKAB1 PRKAB1 PCK2 PCK2 HK2 HK2 CALML6 CALML6 TMEM145 TMEM145 PYGB PYGB PVALEF PVALEF PTPRF PTPRF PHKG2 PHKG2 ENSMNEP00000023757 ENSMNEP00000023757 SHC4 SHC4 PPP1R3A PPP1R3A CBLB CBLB ALKBH4 ALKBH4 SLC2A4 SLC2A4 PTPRS PTPRS G6PC G6PC EXOC7 EXOC7 PIK3CA PIK3CA PPP1R3F PPP1R3F ENSMNEP00000019824 ENSMNEP00000019824 CRKL CRKL SREBF1 SREBF1 CEP152 CEP152 CALML4 CALML4 G6PC2 G6PC2 IRS2 IRS2 TRIP10 TRIP10 PPP1CB PPP1CB ELK1 ELK1 EIF4EBP1 EIF4EBP1 ARAF ARAF PRKAG1 PRKAG1 RPS6KB2 RPS6KB2 ENSMNEP00000016414 ENSMNEP00000016414 ENSMNEP00000016378 ENSMNEP00000016378 RHEBL1 RHEBL1 MAPK3 MAPK3 CRYBB3 CRYBB3 INPPL1 INPPL1 CBL CBL EIF4E1B EIF4E1B FOXO1 FOXO1 SORBS1 SORBS1 HK3 HK3 MAPK8 MAPK8 MAPK1 MAPK1 ENSMNEP00000011545 ENSMNEP00000011545 PRKAA1 PRKAA1 RAPGEF1 RAPGEF1 PRKAR2A PRKAR2A FBP2 FBP2 MTOR MTOR SOCS2 SOCS2 G6PC3 G6PC3 PPARGC1A PPARGC1A PIK3R2 PIK3R2 HK1 HK1 MYO9A MYO9A FBP1 FBP1 SOS2 SOS2 PPP1R3B PPP1R3B MAP2K1 MAP2K1 GSK3B GSK3B ENSMNEP00000005777 ENSMNEP00000005777 BRAF BRAF INSR INSR PRKAA2 PRKAA2 PYGM PYGM RPTOR RPTOR SOCS4 SOCS4 SOCS1 SOCS1 PHKG1 PHKG1 INPP5A INPP5A EIF4E EIF4E SH2B2 SH2B2 LOC105495040 LOC105495040 PKLR PKLR CALML3 CALML3 SOCS3 SOCS3 PRKAB2 PRKAB2 PPP1R3E PPP1R3E MKNK2 MKNK2 PPP1R3D PPP1R3D ERAS ERAS PRKAR1B PRKAR1B PIK3CB PIK3CB EFCAB13 EFCAB13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
PPP1R14BUncharacterized protein. (208 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (582 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PDE3BPhosphodiesterase. (1117 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2135 aa)
BADBCL2 associated agonist of cell death. (167 aa)
TSC2TSC complex subunit 2. (1807 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
CALM1Calmodulin 1. (149 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (505 aa)
PRKAR1AUncharacterized protein. (381 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (383 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
EFCAB3EF-hand calcium binding domain 3. (488 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
LOC10548799140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (244 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IRS4Insulin receptor substrate 4. (1250 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
KIAA1671KIAA1671. (1803 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (182 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1248 aa)
ENSMNEP00000036225SRCR domain-containing protein; Belongs to the eukaryotic initiation factor 4E family. (111 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SHC2Uncharacterized protein. (572 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
SHC1SHC adaptor protein 1. (584 aa)
LIPELipase E, hormone sensitive type. (1056 aa)
ELK3ETS transcription factor ELK3. (407 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
ENSMNEP00000032306Uncharacterized protein. (202 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1240 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
RHOQRas homolog family member Q. (193 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SORBS3Sorbin and SH3 domain containing 3. (725 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
CALM3Calmodulin 3. (149 aa)
FASNFatty acid synthase. (2505 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
MKNK1MAPK interacting serine/threonine kinase 1. (520 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
TSC1TSC complex subunit 1. (1138 aa)
SORBS2Sorbin and SH3 domain containing 2. (1199 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
GCKPhosphotransferase. (466 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1912 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
BUD23BUD23 rRNA methyltransferase and ribosome maturation factor. (297 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SHC3SHC adaptor protein 3. (598 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
HK2Hexokinase 2. (917 aa)
CALML6Calmodulin like 6. (181 aa)
TMEM145Transmembrane protein 145. (563 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1910 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
ENSMNEP00000023757Uncharacterized protein. (369 aa)
SHC4SHC adaptor protein 4. (630 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1145 aa)
CBLBCbl proto-oncogene B. (961 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (302 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (559 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1911 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (711 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (798 aa)
ENSMNEP00000019824Uncharacterized protein. (194 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
CEP152Centrosomal protein 152. (1703 aa)
CALML4Calmodulin like 4. (193 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (353 aa)
IRS2Insulin receptor substrate 2. (1334 aa)
TRIP10Thyroid hormone receptor interactor 10. (601 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ELK1ETS transcription factor ELK1. (428 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENSMNEP00000016414Uncharacterized protein; Belongs to the calmodulin family. (179 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
RHEBL1RHEB like 1. (183 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1333 aa)
CBLCbl proto-oncogene. (907 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
FOXO1Forkhead box O1. (655 aa)
SORBS1Sorbin and SH3 domain containing 1. (1277 aa)
HK3Hexokinase 3. (960 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSMNEP00000011545Uncharacterized protein. (81 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (359 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (340 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
SOCS2Suppressor of cytokine signaling 2. (210 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
PIK3R2Uncharacterized protein. (668 aa)
HK1Hexokinase 1. (921 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2555 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (341 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
ENSMNEP0000000577740S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
INSRTyrosine-protein kinase receptor. (1306 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (421 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (412 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
SH2B2SH2B adaptor protein 2. (680 aa)
LOC105495040Tubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (566 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
ERASES cell expressed Ras. (233 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
EFCAB13EF-hand calcium binding domain 13. (925 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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