STRINGSTRING
MAP2K1 MAP2K1 ITPR1 ITPR1 MAP2K4 MAP2K4 MAP2K7 MAP2K7 PTRHD1 PTRHD1 GNAS GNAS CDC42 CDC42 CALML4 CALML4 PTK2B PTK2B MAP2K3 MAP2K3 PLA2G4E PLA2G4E PLD2 PLD2 ELK1 ELK1 MAP3K4 MAP3K4 GNRH2 GNRH2 ENSMNEP00000016414 ENSMNEP00000016414 PTX3 PTX3 MAPK3 MAPK3 MMP2 MMP2 PLA2G4F PLA2G4F CACNA1C CACNA1C MAPK8 MAPK8 MMP14 MMP14 JMJD7 JMJD7 MAPK11 MAPK11 MAPK1 MAPK1 ENSMNEP00000011554 ENSMNEP00000011554 PLA2G4C PLA2G4C LOC105497223 LOC105497223 HBEGF HBEGF GNAQ GNAQ PLCB4 PLCB4 ADCY1 ADCY1 ADCY7 ADCY7 PLCB2 PLCB2 PLCB3 PLCB3 SOS2 SOS2 SRC SRC PRKCB PRKCB CACNA1S CACNA1S EGFR EGFR ITPR2 ITPR2 ENSMNEP00000004647 ENSMNEP00000004647 ENSMNEP00000034688 ENSMNEP00000034688 PLA2G4D PLA2G4D ADCY9 ADCY9 PLD1 PLD1 CACNA1F CACNA1F FSHB FSHB CALML3 CALML3 ERAS ERAS LOC105470579 LOC105470579 EFCAB13 EFCAB13 ADCY8 ADCY8 ELK3 ELK3 MAP3K2 MAP3K2 ARSI ARSI CAMK2B CAMK2B HRAS HRAS MAP3K1 MAP3K1 PRKACB PRKACB PLA2G4A PLA2G4A PRKCD PRKCD ENSMNEP00000030203 ENSMNEP00000030203 CALM3 CALM3 ENSMNEP00000029022 ENSMNEP00000029022 PRKCA PRKCA MAP3K3 MAP3K3 ATF4 ATF4 ENSMNEP00000027902 ENSMNEP00000027902 GRB2 GRB2 CALM2 CALM2 MAP2K6 MAP2K6 ITPR3 ITPR3 CALML6 CALML6 PVALEF PVALEF RAF1 RAF1 MAPK13 MAPK13 CACNA1D CACNA1D MAPK7 MAPK7 CAMK2G CAMK2G MAPK9 MAPK9 ENSMNEP00000037329 ENSMNEP00000037329 ADCY4 ADCY4 RRAD RRAD GNRH1 GNRH1 GEM GEM MAPK12 MAPK12 LOC105479042 LOC105479042 EFCAB3 EFCAB3 MAPK10 MAPK10 PRKACA PRKACA ADCY6 ADCY6 ADCY5 ADCY5 REM1 REM1 CALM1 CALM1 SOS1 SOS1 MAP2K2 MAP2K2 CAMK2A CAMK2A EGR1 EGR1 PLCB1 PLCB1 GNRHR GNRHR NRAS NRAS ENSMNEP00000045127 ENSMNEP00000045127 ADCY2 ADCY2 CGA CGA KRAS KRAS ADCY3 ADCY3 MAPK14 MAPK14 CSDE1 CSDE1 GNA11 GNA11 CAMK2D CAMK2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (374 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (384 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
GNASGNAS complex locus. (1007 aa)
CDC42Uncharacterized protein. (191 aa)
CALML4Calmodulin like 4. (193 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
PLA2G4EPhospholipase A2. (869 aa)
PLD2Phospholipase. (933 aa)
ELK1ETS transcription factor ELK1. (428 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1791 aa)
GNRH2Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (121 aa)
ENSMNEP00000016414Uncharacterized protein; Belongs to the calmodulin family. (179 aa)
PTX3Pentraxin 3. (392 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
PLA2G4FPhospholipase A2. (849 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
JMJD7Jumonji domain containing 7. (364 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSMNEP00000011554Uncharacterized protein. (157 aa)
PLA2G4CPhospholipase A2 group IVC. (535 aa)
LOC105497223Cys_knot domain-containing protein. (165 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
GNAQG protein subunit alpha q. (359 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1088 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1174 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
SRCTyrosine-protein kinase. (644 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ENSMNEP00000004647Uncharacterized protein. (185 aa)
ENSMNEP00000034688Uncharacterized protein. (288 aa)
PLA2G4DPhospholipase A2. (822 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PLD1Phospholipase. (1074 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
FSHBFollicle stimulating hormone subunit beta. (131 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ERASES cell expressed Ras. (233 aa)
LOC105470579Uncharacterized protein. (245 aa)
EFCAB13EF-hand calcium binding domain 13. (925 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ELK3ETS transcription factor ELK3. (407 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (620 aa)
ARSIArylsulfatase family member I. (569 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1345 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PLA2G4APhospholipase A2. (749 aa)
PRKCDProtein kinase C. (729 aa)
ENSMNEP00000030203Cys_knot domain-containing protein. (141 aa)
CALM3Calmodulin 3. (149 aa)
ENSMNEP00000029022Uncharacterized protein. (185 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
ATF4Activating transcription factor 4. (351 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CALML6Calmodulin like 6. (181 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (813 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
ENSMNEP00000037329Phospholipase A2. (781 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LOC105479042G_PROTEIN_RECEP_F1_2 domain-containing protein. (379 aa)
EFCAB3EF-hand calcium binding domain 3. (488 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1214 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
CALM1Calmodulin 1. (149 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSMNEP00000045127Uncharacterized protein. (183 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (150 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CSDE1Cold shock domain containing E1. (844 aa)
GNA11G protein subunit alpha 11. (346 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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