127 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CREB3	cAMP responsive element binding protein 3. (372 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
	LOC105470579	Uncharacterized protein. (245 aa)
	ERAS	ES cell expressed Ras. (233 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	JUNB	JunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
	SOCS3	Suppressor of cytokine signaling 3. (225 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	SSTR1	Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	SOCS1	Suppressor of cytokine signaling 1. (213 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	SSTR3	Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
	SSTR5	Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1. (361 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1174 aa)
	PIK3R2	Uncharacterized protein. (668 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1088 aa)
	ATF6B	Activating transcription factor 6 beta. (710 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
	POU1F1	POU domain protein. (291 aa)
	SOCS2	Suppressor of cytokine signaling 2. (210 aa)
	GHR	Growth hormone receptor. (645 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
	MAPK11	Mitogen-activated protein kinase. (366 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
	LOC105483030	Uncharacterized protein. (199 aa)
	JAK2	Tyrosine-protein kinase. (1139 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	IGFALS	Insulin like growth factor binding protein acid labile subunit. (605 aa)
	STAT5A	Signal transducer and activator of transcription. (794 aa)
	STAT5B	Signal transducer and activator of transcription. (783 aa)
	IRS2	Insulin receptor substrate 2. (1334 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
	STAT3	Signal transducer and activator of transcription. (660 aa)
	CEP152	Centrosomal protein 152. (1703 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	GNAS	GNAS complex locus. (1007 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (374 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
	GNAI3	G protein subunit alpha i3. (328 aa)
	ADCY10	Adenylate cyclase 10. (1597 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1054 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (916 aa)
	SHC3	SHC adaptor protein 3. (598 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	LOC105469367	Uncharacterized protein. (147 aa)
	LOC105468986	Uncharacterized protein. (227 aa)
	ENSMNEP00000027902	Protein kinase domain-containing protein. (365 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	SSTR2	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (402 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	GNAI1	G protein subunit alpha i1. (422 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1345 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	CRK	CRK proto-oncogene, adaptor protein. (304 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (446 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	SHC2	Uncharacterized protein. (572 aa)
	ENSMNEP00000034688	Uncharacterized protein. (288 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	MAPK9	Mitogen-activated protein kinase 9. (354 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (291 aa)
	ADCY4	Adenylate cyclase 4. (1299 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
	IRS4	Insulin receptor substrate 4. (1250 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (422 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	EP300	E1A binding protein p300. (2397 aa)
	MAPK10	Mitogen-activated protein kinase. (489 aa)
	CREBBP	CREB binding protein. (2442 aa)
	ENSMNEP00000041110	Uncharacterized protein. (177 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1214 aa)
	LOC105483028	Uncharacterized protein. (217 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
	GHRL	Ghrelin and obestatin prepropeptide. (117 aa)
	GHRHR	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (464 aa)
	GH1	Uncharacterized protein. (217 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	GHRH	Growth hormone releasing hormone. (107 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	SST	Somatostatin. (116 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	GNA11	G protein subunit alpha 11. (346 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY10	ENSMNEP00000008537	ENSMNEP00000024576	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 10.	0.446
ADCY1	ADCY2	ENSMNEP00000008537	ENSMNEP00000045150	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.513
ADCY1	ADCY4	ENSMNEP00000008537	ENSMNEP00000037416	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 4.	0.506
ADCY1	ADCY5	ENSMNEP00000008537	ENSMNEP00000041778	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.492
ADCY1	ADCY6	ENSMNEP00000008537	ENSMNEP00000041432	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.492
ADCY1	ADCY7	ENSMNEP00000008537	ENSMNEP00000008144	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.541
ADCY1	ADCY9	ENSMNEP00000008537	ENSMNEP00000003749	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.630
ADCY1	AKT1	ENSMNEP00000008537	ENSMNEP00000026038	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.761
ADCY1	AKT2	ENSMNEP00000008537	ENSMNEP00000028923	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.761
ADCY1	AKT3	ENSMNEP00000008537	ENSMNEP00000038984	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.761
ADCY1	GNAI1	ENSMNEP00000008537	ENSMNEP00000030662	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.786
ADCY1	GNAI2	ENSMNEP00000008537	ENSMNEP00000020560	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.780
ADCY1	GNAI3	ENSMNEP00000008537	ENSMNEP00000024539	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.786
ADCY1	GNAS	ENSMNEP00000008537	ENSMNEP00000021175	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.956
ADCY1	LOC105470579	ENSMNEP00000008537	ENSMNEP00000000695	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.995
ADCY1	PRKACA	ENSMNEP00000008537	ENSMNEP00000041404	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.913
ADCY1	PRKACB	ENSMNEP00000008537	ENSMNEP00000031679	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.936
ADCY1	PRKCA	ENSMNEP00000008537	ENSMNEP00000028729	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.770
ADCY1	PRKCB	ENSMNEP00000008537	ENSMNEP00000005739	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.758
ADCY1	PRKCG	ENSMNEP00000008537	ENSMNEP00000028859	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.764