(58 nodes) Cholesterol metabolism network (Macaca nemestrina)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APOA2	Apolipoprotein A2. (132 aa)
	LDLR	Low density lipoprotein receptor. (783 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1277 aa)
	VDAC1	Uncharacterized protein. (321 aa)
	LRP2	LDL receptor related protein 2. (4655 aa)
	ENSMNEP00000006534	START domain-containing protein. (249 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (673 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (308 aa)
	ENSMNEP00000006959	Uncharacterized protein. (262 aa)
	APOC1	Cholesteryl ester transfer inhibitor protein; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. [...] (129 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (902 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1. (408 aa)
	TSPO	Translocator protein. (169 aa)
	LRPAP1	LDL receptor related protein associated protein 1. (358 aa)
	ANGPTL8	Angiopoietin like 8. (198 aa)
	APOC3	Apolipoprotein C3. (99 aa)
	LRP1B	LDL receptor related protein 1B. (4599 aa)
	VDAC2	Voltage dependent anion channel 2. (308 aa)
	OSBPL5	Oxysterol-binding protein; Belongs to the OSBP family. (879 aa)
	LIPG	Lipase G, endothelial type. (500 aa)
	APOB	Apolipoprotein B. (4555 aa)
	VAPB	VAMP associated protein B and C. (243 aa)
	APOA1	Apolipoprotein A1. (267 aa)
	MYLIP	Myosin regulatory light chain interacting protein. (445 aa)
	STAR	Steroidogenic acute regulatory protein. (294 aa)
	NPC2	NPC intracellular cholesterol transporter 2. (202 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
	VDAC3	Voltage dependent anion channel 3. (284 aa)
	ANGPTL4	Angiopoietin like 4. (406 aa)
	SOAT1	O-acyltransferase. (556 aa)
	LCAT	Lecithin-cholesterol acyltransferase. (440 aa)
	APOA4	Apolipoprotein A4. (435 aa)
	APOC2	Apolipoprotein C2. (101 aa)
	SOAT2	O-acyltransferase. (526 aa)
	LIPA	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (401 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (553 aa)
	VAPA	MSP domain-containing protein. (294 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (811 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (651 aa)
	ENSMNEP00000022499	Uncharacterized protein. (499 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
	LIPC	Lipase C, hepatic type. (500 aa)
	SORT1	Sortilin. (831 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1323 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
	TSPO2	Translocator protein 2. (170 aa)
	ENSMNEP00000020105	MSP domain-containing protein. (267 aa)
	CYP27A1	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (531 aa)
	APOH	Apolipoprotein H. (342 aa)
	ENSMNEP00000018013	Uncharacterized protein. (243 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
	LRP1	LDL receptor related protein 1. (4544 aa)
	STARD3	StAR related lipid transfer domain containing 3. (493 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2268 aa)
	PLTP	Phospholipid transfer protein. (493 aa)
	NR1I3	Nuclear receptor subfamily 1 group I member 3. (357 aa)
	ANGPTL3	Angiopoietin like 3. (460 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ANGPTL3	ENSMNEP00000015634	ENSMNEP00000014045	ATP binding cassette subfamily A member 1.	Angiopoietin like 3.	0.555
ABCA1	APOA1	ENSMNEP00000015634	ENSMNEP00000035632	ATP binding cassette subfamily A member 1.	Apolipoprotein A1.	0.995
ABCA1	APOA2	ENSMNEP00000015634	ENSMNEP00000000098	ATP binding cassette subfamily A member 1.	Apolipoprotein A2.	0.795
ABCA1	APOB	ENSMNEP00000015634	ENSMNEP00000037476	ATP binding cassette subfamily A member 1.	Apolipoprotein B.	0.793
ABCA1	APOC3	ENSMNEP00000015634	ENSMNEP00000044452	ATP binding cassette subfamily A member 1.	Apolipoprotein C3.	0.594
ABCA1	APOE	ENSMNEP00000015634	ENSMNEP00000017988	ATP binding cassette subfamily A member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.789
ABCA1	CD36	ENSMNEP00000015634	ENSMNEP00000008350	ATP binding cassette subfamily A member 1.	CD36 molecule; Belongs to the CD36 family.	0.558
ABCA1	CETP	ENSMNEP00000015634	ENSMNEP00000022195	ATP binding cassette subfamily A member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.678
ABCA1	CYP7A1	ENSMNEP00000015634	ENSMNEP00000033685	ATP binding cassette subfamily A member 1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.569
ABCA1	LCAT	ENSMNEP00000015634	ENSMNEP00000030550	ATP binding cassette subfamily A member 1.	Lecithin-cholesterol acyltransferase.	0.710
ABCA1	LIPC	ENSMNEP00000015634	ENSMNEP00000021881	ATP binding cassette subfamily A member 1.	Lipase C, hepatic type.	0.609
ABCA1	LIPG	ENSMNEP00000015634	ENSMNEP00000041613	ATP binding cassette subfamily A member 1.	Lipase G, endothelial type.	0.515
ABCA1	NPC1	ENSMNEP00000015634	ENSMNEP00000000403	ATP binding cassette subfamily A member 1.	NPC intracellular cholesterol transporter 1.	0.583
ABCA1	PLTP	ENSMNEP00000015634	ENSMNEP00000014423	ATP binding cassette subfamily A member 1.	Phospholipid transfer protein.	0.578
ABCA1	SCARB1	ENSMNEP00000015634	ENSMNEP00000027764	ATP binding cassette subfamily A member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.556
ABCB11	CYP7A1	ENSMNEP00000020777	ENSMNEP00000033685	ATP binding cassette subfamily B member 11.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.559
ABCB11	LCAT	ENSMNEP00000020777	ENSMNEP00000030550	ATP binding cassette subfamily B member 11.	Lecithin-cholesterol acyltransferase.	0.450
ABCB11	NPC1	ENSMNEP00000020777	ENSMNEP00000000403	ATP binding cassette subfamily B member 11.	NPC intracellular cholesterol transporter 1.	0.567
ABCG5	ABCG8	ENSMNEP00000023658	ENSMNEP00000006603	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 8.	0.999
ABCG5	APOB	ENSMNEP00000023658	ENSMNEP00000037476	ATP binding cassette subfamily G member 5.	Apolipoprotein B.	0.427