(72 nodes) Amphetamine addiction network (Macaca nemestrina)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	CAMK2D	Calcium/calmodulin dependent protein kinase II delta. (533 aa)
	SLC18A1	Solute carrier family 18 member A1. (525 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
	CREB3	cAMP responsive element binding protein 3. (372 aa)
	CALM1	Calmodulin 1. (149 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1299 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
	PPP3R1	Uncharacterized protein. (189 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (520 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (422 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	CAMK2G	Calcium/calmodulin dependent protein kinase II gamma. (556 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (893 aa)
	GRIA4	Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (446 aa)
	ARSI	Arylsulfatase family member I. (569 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (666 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	PDYN	Prodynorphin. (253 aa)
	PPP1CC	Serine/threonine-protein phosphatase. (293 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (302 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
	CALM3	Calmodulin 3. (149 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	TH	Tyrosine hydroxylase. (529 aa)
	MAOB	Amine oxidase. (520 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (483 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	CALM2	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	CALML6	Calmodulin like 6. (181 aa)
	PVALEF	Parvalbumin like EF-hand containing. (133 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (901 aa)
	SIRT1	Sirtuin 1. (743 aa)
	GNAS	GNAS complex locus. (1007 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
	CALML4	Calmodulin like 4. (193 aa)
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	ENSMNEP00000017045	Hist_deacetyl domain-containing protein. (247 aa)
	ENSMNEP00000016650	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa)
	ENSMNEP00000016414	Uncharacterized protein; Belongs to the calmodulin family. (179 aa)
	ENSMNEP00000015951	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (443 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (996 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	ARC	Activity regulated cytoskeleton associated protein. (471 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	CAMK4	Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
	DDC	Dopa decarboxylase. (480 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	LOC105470579	Uncharacterized protein. (245 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	SLC18A2	Solute carrier family 18 member A2. (517 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	MAOA	Amine oxidase. (527 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	ATF6B	Activating transcription factor 6 beta. (710 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1242 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	CALM1	ENSMNEP00000041778	ENSMNEP00000042675	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1.	0.433
ADCY5	CALM2	ENSMNEP00000041778	ENSMNEP00000026788	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.433
ADCY5	CALM3	ENSMNEP00000041778	ENSMNEP00000029674	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3.	0.433
ADCY5	CALML3	ENSMNEP00000041778	ENSMNEP00000001834	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.777
ADCY5	CALML4	ENSMNEP00000041778	ENSMNEP00000018578	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.869
ADCY5	CALML6	ENSMNEP00000041778	ENSMNEP00000024512	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.690
ADCY5	CAMK2A	ENSMNEP00000041778	ENSMNEP00000043407	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.755
ADCY5	CAMK2B	ENSMNEP00000041778	ENSMNEP00000032011	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.754
ADCY5	CAMK2D	ENSMNEP00000041778	ENSMNEP00000046054	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II delta.	0.754
ADCY5	CAMK2G	ENSMNEP00000041778	ENSMNEP00000036455	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II gamma.	0.530
ADCY5	CAMK4	ENSMNEP00000041778	ENSMNEP00000013433	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily.	0.751
ADCY5	ENSMNEP00000016414	ENSMNEP00000041778	ENSMNEP00000016414	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.433
ADCY5	GNAS	ENSMNEP00000041778	ENSMNEP00000021175	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.974
ADCY5	LOC105470579	ENSMNEP00000041778	ENSMNEP00000000695	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.995
ADCY5	PRKACA	ENSMNEP00000041778	ENSMNEP00000041404	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.845
ADCY5	PRKACB	ENSMNEP00000041778	ENSMNEP00000031679	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.946
ADCY5	PRKCA	ENSMNEP00000041778	ENSMNEP00000028729	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.859
ADCY5	PRKCB	ENSMNEP00000041778	ENSMNEP00000005739	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.780
ADCY5	PRKCG	ENSMNEP00000041778	ENSMNEP00000028859	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.763
ARC	CAMK2B	ENSMNEP00000013891	ENSMNEP00000032011	Activity regulated cytoskeleton associated protein.	Calcium/calmodulin dependent protein kinase II beta.	0.549