STRINGSTRING
NOD1 NOD1 IL23A IL23A CXCL6 CXCL6 GNAI3 GNAI3 CALML6 CALML6 PVALEF PVALEF CXCL8 CXCL8 TIRAP TIRAP LOC105485223 LOC105485223 C4BPA C4BPA GNAI2 GNAI2 CCDC125 CCDC125 C1QA C1QA CFL1 CFL1 IL12B IL12B LOC105477289 LOC105477289 CALML4 CALML4 SFTPA1 SFTPA1 ENSMNEP00000016854 ENSMNEP00000016854 ENSMNEP00000016414 ENSMNEP00000016414 IRF1 IRF1 MAPK3 MAPK3 CD14 CD14 FOS FOS ITGB2 ITGB2 NOS2 NOS2 ENSMNEP00000013201 ENSMNEP00000013201 MAPK8 MAPK8 TMED7 TMED7 ENSMNEP00000012002 ENSMNEP00000012002 C1RL C1RL MAPK11 MAPK11 MAPK1 MAPK1 NFKB1 NFKB1 SERPING1 SERPING1 LOC105477295 LOC105477295 IRF8 IRF8 LY96 LY96 LOC105492342 LOC105492342 ENSMNEP00000005419 ENSMNEP00000005419 TICAM2 TICAM2 IRAK1 IRAK1 ITGB1 ITGB1 ENSMNEP00000004019 ENSMNEP00000004019 C4BPB C4BPB C1QC C1QC C5 C5 CALML3 CALML3 C1R C1R IL6 IL6 EFCAB13 EFCAB13 PYCARD PYCARD MAPK9 MAPK9 IL10 IL10 C4A C4A TRAF6 TRAF6 RHOA RHOA MAPK12 MAPK12 EFCAB3 EFCAB3 MAPK10 MAPK10 ENSMNEP00000041202 ENSMNEP00000041202 ENSMNEP00000041867 ENSMNEP00000041867 NLRP3 NLRP3 IL12A IL12A CALM1 CALM1 MAPK14 MAPK14 TMED3 TMED3 C1S C1S TLR4 TLR4 MAPK13 MAPK13 ITGAM ITGAM IL1A IL1A IL1B IL1B IRAK4 IRAK4 MYD88 MYD88 CFL2 CFL2 C3 C3 GNAI1 GNAI1 CALM3 CALM3 C1QB C1QB TICAM1 TICAM1 TNF TNF LOC105484870 LOC105484870 RELA RELA LOC105477893 LOC105477893 IRF3 IRF3 ITGA5 ITGA5 CALM2 CALM2 RHOC RHOC CASP7 CASP7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
CXCL6C-X-C motif chemokine. (123 aa)
GNAI3G protein subunit alpha i3. (328 aa)
CALML6Calmodulin like 6. (181 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
LOC105485223NTR domain-containing protein. (131 aa)
C4BPAComplement component 4 binding protein alpha. (598 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CCDC125Coiled-coil domain containing 125. (510 aa)
C1QAUncharacterized protein. (266 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (196 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
LOC105477289C-X-C motif chemokine. (114 aa)
CALML4Calmodulin like 4. (193 aa)
SFTPA1C-type lectin domain-containing protein. (248 aa)
ENSMNEP00000016854ADF-H domain-containing protein. (135 aa)
ENSMNEP00000016414Uncharacterized protein; Belongs to the calmodulin family. (179 aa)
IRF1Interferon regulatory factor. (325 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ITGB2Integrin beta. (921 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1063 aa)
ENSMNEP00000013201C-type lectin domain-containing protein. (239 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TMED7Transmembrane p24 trafficking protein 7. (224 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
C1RLComplement C1r subcomponent like. (433 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (526 aa)
LOC105477295C-X-C motif chemokine. (114 aa)
IRF8Interferon regulatory factor 8. (434 aa)
LY96MD-2. (160 aa)
LOC105492342Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
ENSMNEP00000005419Uncharacterized protein. (114 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (717 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ENSMNEP00000004019Uncharacterized protein; Belongs to the peptidase C14A family. (242 aa)
C4BPBComplement component 4 binding protein beta. (252 aa)
C1QCComplement C1q C chain. (245 aa)
C5Complement C5. (1676 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (690 aa)
IL6Interleukin 6. (214 aa)
EFCAB13EF-hand calcium binding domain 13. (925 aa)
PYCARDPYD and CARD domain containing. (195 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
C4AUncharacterized protein. (1744 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RHOARas homolog family member A. (193 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
EFCAB3EF-hand calcium binding domain 3. (488 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
ENSMNEP00000041202ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (209 aa)
ENSMNEP00000041867Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
CALM1Calmodulin 1. (149 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TMED3Transmembrane p24 trafficking protein 3. (246 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (596 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1153 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (224 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
C3Complement C3. (1642 aa)
GNAI1G protein subunit alpha i1. (422 aa)
CALM3Calmodulin 3. (149 aa)
C1QBComplement C1q B chain. (253 aa)
TICAM1Toll like receptor adaptor molecule 1. (519 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC105484870Uncharacterized protein. (594 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
LOC105477893Uncharacterized protein. (1747 aa)
IRF3Interferon regulatory factor 3. (422 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
RHOCRas homolog family member C. (193 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (377 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (16%) [HD]