Your Input: | |
| | ENSMNEP00000034688 | Uncharacterized protein. (288 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) |
| | ENSMNEP00000036315 | Uncharacterized protein. (182 aa) |
| | LIMK1 | LIM domain kinase 1. (677 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | MAPK9 | Mitogen-activated protein kinase 9. (354 aa) |
| | BAIAP2 | BAI1 associated protein 2. (552 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | GIT2 | GIT ArfGAP 2. (760 aa) |
| | ENSMNEP00000038177 | Uncharacterized protein; Belongs to the actin family. (156 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (463 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (489 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | ENSMNEP00000041206 | Uncharacterized protein; Belongs to the actin family. (163 aa) |
| | ENSMNEP00000041446 | Uncharacterized protein. (60 aa) |
| | ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1035 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | ACTR2 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa) |
| | ROCK2 | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa) |
| | ACTL8 | Actin like 8; Belongs to the actin family. (366 aa) |
| | ENSMNEP00000045127 | Uncharacterized protein. (183 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | WIPF1 | WAS/WASL interacting protein family member 1. (510 aa) |
| | TRAV22 | T cell receptor alpha variable 22. (147 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | ENSMNEP00000032785 | PIPK domain-containing protein. (470 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | LCP2 | Lymphocyte cytosolic protein 2. (533 aa) |
| | RAC1 | Rac family small GTPase 1. (211 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (862 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | CCL2 | C-C motif chemokine. (99 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | TRAC | T cell receptor alpha constant. (110 aa) |
| | PXN | Paxillin. (1082 aa) |
| | ACTRT2 | Actin related protein T2; Belongs to the actin family. (377 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (519 aa) |
| | ACTL7A | Actin like 7A; Belongs to the actin family. (435 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | ENSMNEP00000029022 | Uncharacterized protein. (185 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | ENSMNEP00000028956 | Uncharacterized protein. (185 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa) |
| | ENSMNEP00000028604 | IGv domain-containing protein. (139 aa) |
| | ENSMNEP00000028540 | Uncharacterized protein. (139 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (548 aa) |
| | MEFV | MEFV innate immuity regulator, pyrin. (786 aa) |
| | IRF3 | Interferon regulatory factor 3. (422 aa) |
| | ENSMNEP00000027902 | Protein kinase domain-containing protein. (365 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa) |
| | RHOC | Ras homolog family member C. (193 aa) |
| | LPXN | Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa) |
| | ENSMNEP00000026694 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (353 aa) |
| | LCK | Tyrosine-protein kinase. (540 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | ENSMNEP00000025520 | Ig-like domain-containing protein. (194 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (916 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1054 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (878 aa) |
| | WASL | WASP like actin nucleation promoting factor. (505 aa) |
| | FCGR2B | Uncharacterized protein. (313 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (374 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (384 aa) |
| | ARF6 | ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa) |
| | LAT | Linker for activation of T cells. (271 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | DOCK1 | Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (921 aa) |
| | ELMO2 | Engulfment and cell motility 2. (720 aa) |
| | ENSMNEP00000021289 | Ig-like domain-containing protein. (182 aa) |
| | CDC42 | Uncharacterized protein. (191 aa) |
| | WAS | WASP actin nucleation promoting factor. (545 aa) |
| | ENSMNEP00000020833 | Ig-like domain-containing protein. (145 aa) |
| | PKN2 | Protein kinase N2. (983 aa) |
| | ACTB | Actin beta. (379 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1484 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (846 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | ENSMNEP00000019244 | Uncharacterized protein. (175 aa) |
| | WASF2 | WASP family member 2. (499 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | ACTR3B | Actin related protein 3B; Belongs to the actin family. (418 aa) |
| | FYB1 | FYN binding protein 1. (839 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | ARHGEF28 | Rho guanine nucleotide exchange factor 28. (1729 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | ENSMNEP00000012002 | TNF receptor-associated factor. (457 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa) |
| | WIPF2 | WAS/WASL interacting protein family member 2. (246 aa) |
| | ENSMNEP00000011554 | Uncharacterized protein. (157 aa) |
| | CD8B | Ig-like domain-containing protein. (243 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) |
| | FN1 | Fibronectin 1. (2477 aa) |
| | ENSMNEP00000010506 | Ig-like domain-containing protein. (142 aa) |
| | ENSMNEP00000010486 | Ig-like domain-containing protein. (133 aa) |
| | GNAQ | G protein subunit alpha q. (359 aa) |
| | SKAP2 | Src kinase associated phosphoprotein 2. (359 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (875 aa) |
| | RPS6KA6 | Ribosomal protein S6 kinase. (745 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1. (972 aa) |
| | CD8A | CD8a molecule. (253 aa) |
| | RAC3 | Rac family small GTPase 3. (192 aa) |
| | PIK3R2 | Uncharacterized protein. (668 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (723 aa) |
| | WIPF3 | WAS/WASL interacting protein family member 3. (500 aa) |
| | ENSMNEP00000007520 | CARD domain-containing protein. (359 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1. (361 aa) |
| | SRC | Tyrosine-protein kinase. (644 aa) |
| | ENSMNEP00000006186 | Uncharacterized protein. (184 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa) |
| | ENSMNEP00000005419 | Uncharacterized protein. (114 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1075 aa) |
| | PIP5K1C | Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (705 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (717 aa) |
| | ENSMNEP00000004647 | Uncharacterized protein. (185 aa) |
| | ACTRT1 | Actin related protein T1; Belongs to the actin family. (375 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa) |
| | ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (801 aa) |
| | PKN1 | Protein kinase N1. (949 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (612 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (988 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | ACTL7B | Actin like 7B; Belongs to the actin family. (415 aa) |
| | ACTR3 | Actin related protein 3; Belongs to the actin family. (418 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (554 aa) |
| | ACTG1 | Actin gamma 1. (377 aa) |
| | ELMO1 | Engulfment and cell motility 1. (727 aa) |
| | ENSMNEP00000001351 | Ig-like domain-containing protein. (151 aa) |
| | RHOG | Uncharacterized protein. (191 aa) |
| | ENSMNEP00000000821 | Ig-like domain-containing protein. (143 aa) |
| | IL6 | Interleukin 6. (214 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) |
