STRINGSTRING
RELA RELA ENSMNEP00000000821 ENSMNEP00000000821 STAT1 STAT1 ENSMNEP00000001351 ENSMNEP00000001351 TLR2 TLR2 JAK1 JAK1 HLA-DOA HLA-DOA ENSMNEP00000002245 ENSMNEP00000002245 TAB2 TAB2 HLA-DRA HLA-DRA ITGB1 ITGB1 ENSMNEP00000004521 ENSMNEP00000004521 LOC105470433 LOC105470433 IRAK1 IRAK1 ENSMNEP00000004839 ENSMNEP00000004839 PRKCB PRKCB CYBB CYBB ENSMNEP00000009424 ENSMNEP00000009424 ENSMNEP00000010506 ENSMNEP00000010506 HLA-DPB1 HLA-DPB1 NFKB1 NFKB1 MAPK1 MAPK1 MAPK11 MAPK11 ENSMNEP00000012002 ENSMNEP00000012002 NOS2 NOS2 ENSMNEP00000013480 ENSMNEP00000013480 CR1L CR1L ITGB2 ITGB2 JAK2 JAK2 FOS FOS NCF2 NCF2 MAPK3 MAPK3 ELK1 ELK1 HLA-DMA HLA-DMA NCF1 NCF1 NCF4 NCF4 ENSMNEP00000018421 ENSMNEP00000018421 ENSMNEP00000018709 ENSMNEP00000018709 PTGS2 PTGS2 FCGR1A FCGR1A IL12B IL12B LOC105470432 LOC105470432 IL4 IL4 ENSMNEP00000020833 ENSMNEP00000020833 ENSMNEP00000021289 ENSMNEP00000021289 IFNGR2 IFNGR2 NOXA1 NOXA1 FCGR2B FCGR2B EEF1A1 EEF1A1 ENSMNEP00000025520 ENSMNEP00000025520 CR1 CR1 LOC105477893 LOC105477893 TNF TNF PTPN6 PTPN6 HLA-DQA1 HLA-DQA1 C3 C3 LOC105498220 LOC105498220 MYD88 MYD88 MAP3K7 MAP3K7 NFKBIA NFKBIA IRAK4 IRAK4 IL1B IL1B IL1A IL1A ENSMNEP00000033999 ENSMNEP00000033999 CYBA CYBA ITGAM ITGAM MAPK13 MAPK13 TLR4 TLR4 ENSMNEP00000035156 ENSMNEP00000035156 HLA-DPA1 HLA-DPA1 IL10 IL10 FAM229A FAM229A TRAF6 TRAF6 ENSMNEP00000038649 ENSMNEP00000038649 TAB1 TAB1 IFNGR1 IFNGR1 MAPK12 MAPK12 TGFB1 TGFB1 TGFB2 TGFB2 TGFB3 TGFB3 HLA-DOB HLA-DOB ITGA4 ITGA4 IL12A IL12A ENSMNEP00000042851 ENSMNEP00000042851 LOC105474413 LOC105474413 LOC105474426 LOC105474426 NFKBIB NFKBIB EEF1A2 EEF1A2 IFNG IFNG MARCKSL1 MARCKSL1 MAPK14 MAPK14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
ENSMNEP00000000821Ig-like domain-containing protein. (143 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
ENSMNEP00000001351Ig-like domain-containing protein. (151 aa)
TLR2Toll-like receptor. (784 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
ENSMNEP00000002245Ig-like domain-containing protein. (232 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ENSMNEP00000004521Ig-like domain-containing protein. (230 aa)
LOC105470433MHC class II antigen. (260 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (717 aa)
ENSMNEP00000004839Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (433 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CYBBCytochrome b-245 beta chain. (614 aa)
ENSMNEP00000009424Ig-like domain-containing protein. (161 aa)
ENSMNEP00000010506Ig-like domain-containing protein. (142 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (268 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1063 aa)
ENSMNEP00000013480Tr-type G domain-containing protein. (409 aa)
CR1LComplement C3b/C4b receptor 1 like. (569 aa)
ITGB2Integrin beta. (921 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ELK1ETS transcription factor ELK1. (428 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
ENSMNEP00000018421Tr-type G domain-containing protein. (113 aa)
ENSMNEP00000018709Ig-like domain-containing protein. (122 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
FCGR1AUncharacterized protein. (357 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
LOC105470432Ig-like domain-containing protein; Belongs to the MHC class II family. (260 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
ENSMNEP00000020833Ig-like domain-containing protein. (145 aa)
ENSMNEP00000021289Ig-like domain-containing protein. (182 aa)
IFNGR2Interferon gamma receptor 2. (312 aa)
NOXA1NADPH oxidase activator 1. (476 aa)
FCGR2BUncharacterized protein. (313 aa)
EEF1A1Uncharacterized protein. (330 aa)
ENSMNEP00000025520Ig-like domain-containing protein. (194 aa)
CR1Complement C3b/C4b receptor 1 (Knops blood group). (1649 aa)
LOC105477893Uncharacterized protein. (1747 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (267 aa)
C3Complement C3. (1642 aa)
LOC105498220Uncharacterized protein. (342 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (224 aa)
ENSMNEP00000033999Tr-type G domain-containing protein. (422 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1153 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
ENSMNEP00000035156Tr-type G domain-containing protein. (113 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
FAM229AFamily with sequence similarity 229 member A. (127 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ENSMNEP00000038649Ig-like domain-containing protein. (235 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (285 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ENSMNEP00000042851Tr-type G domain-containing protein. (113 aa)
LOC105474413Ig-like domain-containing protein. (295 aa)
LOC105474426Ig-like domain-containing protein. (263 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
MARCKSL1MARCKS like 1. (195 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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