STRINGSTRING
ENSMNEP00000000821 ENSMNEP00000000821 ENSMNEP00000001351 ENSMNEP00000001351 LOC105481481 LOC105481481 PRKCB PRKCB THOP1 THOP1 FAS FAS PLCB3 PLCB3 PLCB2 PLCB2 PLCB4 PLCB4 ENSMNEP00000009424 ENSMNEP00000009424 HP HP GNAQ GNAQ ENSMNEP00000010506 ENSMNEP00000010506 LOC105468622 LOC105468622 HBZ HBZ SELE SELE ICAM1 ICAM1 ENSMNEP00000018709 ENSMNEP00000018709 IL12B IL12B AADACL2 AADACL2 ENSMNEP00000020833 ENSMNEP00000020833 IDO2 IDO2 ENSMNEP00000021289 ENSMNEP00000021289 VCAM1 VCAM1 AADAC AADAC ENSMNEP00000025520 ENSMNEP00000025520 HBQ1 HBQ1 LAMA4 LAMA4 NPPA NPPA PRKCA PRKCA PRKCG PRKCG TNF TNF NGB NGB MYD88 MYD88 ENSMNEP00000032655 ENSMNEP00000032655 IL1B IL1B FASLG FASLG ENSMNEP00000034688 ENSMNEP00000034688 HBM HBM APOA1 APOA1 MB MB IL6 IL6 IL10 IL10 CYGB CYGB IDO1 IDO1 HBE1 HBE1 APOL6 APOL6 IL18 IL18 ENSMNEP00000040460 ENSMNEP00000040460 IL12A IL12A PLCB1 PLCB1 KNG1 KNG1 IFNG IFNG LOC105480535 LOC105480535
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMNEP00000000821Ig-like domain-containing protein. (143 aa)
ENSMNEP00000001351Ig-like domain-containing protein. (151 aa)
LOC105481481GLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
THOP1Thimet oligopeptidase 1. (687 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1174 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ENSMNEP00000009424Ig-like domain-containing protein. (161 aa)
HPPeptidase S1 domain-containing protein. (426 aa)
GNAQG protein subunit alpha q. (359 aa)
ENSMNEP00000010506Ig-like domain-containing protein. (142 aa)
LOC105468622Hemoglobin subunit gamma; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains; Belongs to the globin family. (147 aa)
HBZHemoglobin subunit zeta; Belongs to the globin family. (142 aa)
SELESelectin E. (612 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
ENSMNEP00000018709Ig-like domain-containing protein. (122 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
AADACL2Arylacetamide deacetylase like 2. (401 aa)
ENSMNEP00000020833Ig-like domain-containing protein. (145 aa)
IDO2Indoleamine 2,3-dioxygenase 2. (420 aa)
ENSMNEP00000021289Ig-like domain-containing protein. (182 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
AADACArylacetamide deacetylase. (399 aa)
ENSMNEP00000025520Ig-like domain-containing protein. (194 aa)
HBQ1Hemoglobin subunit theta 1; Belongs to the globin family. (142 aa)
LAMA4Laminin subunit alpha 4. (1816 aa)
NPPANatriuretic peptide A. (153 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NGBNeuroglobin; Belongs to the globin family. (151 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
ENSMNEP00000032655Uncharacterized protein. (98 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
ENSMNEP00000034688Uncharacterized protein. (288 aa)
HBMHemoglobin subunit mu; Belongs to the globin family. (141 aa)
APOA1Apolipoprotein A1. (267 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
IL6Interleukin 6. (214 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
CYGBCytoglobin; Belongs to the globin family. (202 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (403 aa)
HBE1Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (147 aa)
APOL6Apolipoprotein L6. (340 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ENSMNEP00000040460Uncharacterized protein. (344 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
KNG1Kininogen 1. (618 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
LOC105480535TIR domain-containing protein. (1033 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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