STRINGSTRING
ENSMNEP00000012002 ENSMNEP00000012002 PPP1R14B PPP1R14B PDPK1 PDPK1 MAPK14 MAPK14 IFNG IFNG GNAO1 GNAO1 PIK3R5 PIK3R5 LAMB2 LAMB2 NFKBIB NFKBIB BAD BAD LOC105474426 LOC105474426 LOC105474413 LOC105474413 IL12A IL12A ENSMNEP00000041867 ENSMNEP00000041867 HLA-DOB HLA-DOB TGFB3 TGFB3 TGFB2 TGFB2 MAPK10 MAPK10 LAMC1 LAMC1 ENSMNEP00000040265 ENSMNEP00000040265 TGFB1 TGFB1 MAPK12 MAPK12 IFNGR1 IFNGR1 AKT3 AKT3 TAB1 TAB1 ENSMNEP00000038649 ENSMNEP00000038649 TRAF6 TRAF6 PIK3CG PIK3CG IL10 IL10 MAPK9 MAPK9 C7orf31 C7orf31 HLA-DPA1 HLA-DPA1 CYCS CYCS TLR4 TLR4 MAPK13 MAPK13 ALOX5 ALOX5 ITGA6 ITGA6 LAMA5 LAMA5 BIRC3 BIRC3 BIRC7 BIRC7 IKBKB IKBKB IRAK4 IRAK4 CASP8 CASP8 NFKBIA NFKBIA MAP3K7 MAP3K7 MYD88 MYD88 CD40LG CD40LG CIITA CIITA HSPA8 HSPA8 LAMA1 LAMA1 ENSMNEP00000031290 ENSMNEP00000031290 LAMA3 LAMA3 TYK2 TYK2 GNAI1 GNAI1 HLA-DQA1 HLA-DQA1 ENSMNEP00000030339 ENSMNEP00000030339 TNF TNF BIRC2 BIRC2 AKT2 AKT2 RELA RELA LAMB1 LAMB1 XIAP XIAP MAP2K6 MAP2K6 LAMA4 LAMA4 AKT1 AKT1 GNAI3 GNAI3 ENSMNEP00000023823 ENSMNEP00000023823 BCL2 BCL2 IRGM IRGM LAMC2 LAMC2 IL10RA IL10RA IFNGR2 IFNGR2 HSPA2 HSPA2 GNAI2 GNAI2 HSPA6 HSPA6 PIK3R6 PIK3R6 LOC105470432 LOC105470432 ENSMNEP00000019824 ENSMNEP00000019824 IL12B IL12B STAT3 STAT3 MAP2K3 MAP2K3 HLA-DMA HLA-DMA CASP9 CASP9 LAMA2 LAMA2 MAPK3 MAPK3 JAK2 JAK2 NOS2 NOS2 MAPK8 MAPK8 CHUK CHUK LAMC3 LAMC3 CCR5 CCR5 IL10RB IL10RB MAPK11 MAPK11 MAPK1 MAPK1 ENSMNEP00000011844 ENSMNEP00000011844 TNFRSF1A TNFRSF1A ENSMNEP00000011545 ENSMNEP00000011545 LOC105498547 LOC105498547 LAMB4 LAMB4 NFKB1 NFKB1 HLA-DPB1 HLA-DPB1 PPIF PPIF LY96 LY96 LOC105492342 LOC105492342 LOC105477715 LOC105477715 IRAK1 IRAK1 LOC105470433 LOC105470433 LOC105495023 LOC105495023 ENSMNEP00000004521 ENSMNEP00000004521 ITGB1 ITGB1 HLA-DRA HLA-DRA LOC105477037 LOC105477037 ENSMNEP00000004019 ENSMNEP00000004019 LOC105486922 LOC105486922 TAB2 TAB2 SOCS1 SOCS1 BCL2L1 BCL2L1 ENSMNEP00000002245 ENSMNEP00000002245 CD40 CD40 LOC105495842 LOC105495842 HLA-DOA HLA-DOA JAK1 JAK1 TLR2 TLR2 LOC105497820 LOC105497820 LOC105491771 LOC105491771 STAT1 STAT1 LOC105487609 LOC105487609 LAMB3 LAMB3 HSPA1L HSPA1L IKBKG IKBKG LDLR LDLR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
PPP1R14BUncharacterized protein. (208 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (582 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
GNAO1G protein subunit alpha o1. (354 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
BADBCL2 associated agonist of cell death. (167 aa)
LOC105474426Ig-like domain-containing protein. (263 aa)
LOC105474413Ig-like domain-containing protein. (295 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ENSMNEP00000041867Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (285 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
ENSMNEP00000040265Uncharacterized protein; Belongs to the heat shock protein 70 family. (586 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ENSMNEP00000038649Ig-like domain-containing protein. (235 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
LAMA5Laminin subunit alpha 5. (3696 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (487 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
CIITAClass II major histocompatibility complex transactivator. (1235 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
LAMA1Laminin subunit alpha 1. (3079 aa)
ENSMNEP00000031290Uncharacterized protein; Belongs to the heat shock protein 70 family. (579 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
GNAI1G protein subunit alpha i1. (422 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (267 aa)
ENSMNEP00000030339Uncharacterized protein. (459 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LAMA4Laminin subunit alpha 4. (1816 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNAI3G protein subunit alpha i3. (328 aa)
ENSMNEP00000023823Uncharacterized protein; Belongs to the heat shock protein 70 family. (520 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
IRGMImmunity related GTPase M. (170 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
IL10RAInterleukin 10 receptor subunit alpha. (580 aa)
IFNGR2Interferon gamma receptor 2. (312 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (602 aa)
GNAI2G protein subunit alpha i2. (355 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (537 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (867 aa)
LOC105470432Ig-like domain-containing protein; Belongs to the MHC class II family. (260 aa)
ENSMNEP00000019824Uncharacterized protein. (194 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1063 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
LAMC3Laminin subunit gamma 3. (1468 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSMNEP00000011844Uncharacterized protein. (424 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
ENSMNEP00000011545Uncharacterized protein. (81 aa)
LOC105498547Uncharacterized protein; Belongs to the heat shock protein 70 family. (551 aa)
LAMB4Laminin subunit beta 4. (1762 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (268 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
LY96MD-2. (160 aa)
LOC105492342Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
LOC105477715Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (717 aa)
LOC105470433MHC class II antigen. (260 aa)
LOC105495023Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
ENSMNEP00000004521Ig-like domain-containing protein. (230 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
LOC105477037Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSMNEP00000004019Uncharacterized protein; Belongs to the peptidase C14A family. (242 aa)
LOC105486922Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
BCL2L1BCL2 like 1. (233 aa)
ENSMNEP00000002245Ig-like domain-containing protein. (232 aa)
CD40CD40 molecule. (278 aa)
LOC105495842Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
TLR2Toll-like receptor. (784 aa)
LOC105497820Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC105491771Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
LOC105487609Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa)
LDLRLow density lipoprotein receptor. (783 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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