STRINGSTRING
MAPK1 MAPK1 PPP1R14B PPP1R14B BIRC5 BIRC5 CSDE1 CSDE1 KRAS KRAS MLH1 MLH1 RPS6KB1 RPS6KB1 TCF7L1 TCF7L1 NRAS NRAS BAD BAD RALGDS RALGDS DCC DCC MAP2K2 MAP2K2 SOS1 SOS1 TCF7 TCF7 BCL2L11 BCL2L11 APC APC ENSMNEP00000041867 ENSMNEP00000041867 LEF1 LEF1 TGFB3 TGFB3 TGFB2 TGFB2 MAPK10 MAPK10 TGFB1 TGFB1 GADD45G GADD45G RALB RALB AKT3 AKT3 PIK3R3 PIK3R3 RHOA RHOA AXIN1 AXIN1 MAPK9 MAPK9 ENSMNEP00000036315 ENSMNEP00000036315 TGFBR2 TGFBR2 C7orf31 C7orf31 CYCS CYCS CCND1 CCND1 RAF1 RAF1 ENSMNEP00000034090 ENSMNEP00000034090 EREG EREG MSH6 MSH6 TCF7L2 TCF7L2 HRAS HRAS RAC1 RAC1 PIK3CD PIK3CD TP53 TP53 PIK3R1 PIK3R1 GADD45B GADD45B ENSMNEP00000028956 ENSMNEP00000028956 AKT2 AKT2 SMAD2 SMAD2 ENSMNEP00000027902 ENSMNEP00000027902 TGFA TGFA GRB2 GRB2 RHOC RHOC AREG AREG MSH2 MSH2 AKT1 AKT1 BCL2 BCL2 BAX BAX PIK3CA PIK3CA ENSMNEP00000019824 ENSMNEP00000019824 EGF EGF RAC2 RAC2 APPL1 APPL1 SMAD3 SMAD3 APC2 APC2 CASP9 CASP9 ARAF ARAF MSH3 MSH3 RPS6KB2 RPS6KB2 ENSMNEP00000016378 ENSMNEP00000016378 MAPK3 MAPK3 PMAIP1 PMAIP1 TGFBR1 TGFBR1 FOS FOS SMAD4 SMAD4 EPGN EPGN MAPK8 MAPK8 ENSMNEP00000012161 ENSMNEP00000012161 ENSMNEP00000011545 ENSMNEP00000011545 BAK1 BAK1 MTOR MTOR DDB2 DDB2 ENSMNEP00000009362 ENSMNEP00000009362 RALA RALA GADD45A GADD45A RAC3 RAC3 PIK3R2 PIK3R2 LOC105480640 LOC105480640 SOS2 SOS2 MAP2K1 MAP2K1 GSK3B GSK3B BRAF BRAF LOC105492342 LOC105492342 ENSMNEP00000005419 ENSMNEP00000005419 EGFR EGFR LOC105477715 LOC105477715 LOC105495023 LOC105495023 MYC MYC LOC105477037 LOC105477037 ENSMNEP00000004019 ENSMNEP00000004019 LOC105486922 LOC105486922 POLK POLK ENSMNEP00000002161 ENSMNEP00000002161 BBC3 BBC3 LOC105495842 LOC105495842 CDKN1A CDKN1A LOC105497820 LOC105497820 LOC105491771 LOC105491771 LOC105464688 LOC105464688 CTNNB1 CTNNB1 ERAS ERAS LOC105487609 LOC105487609 RGL4 RGL4 PIK3CB PIK3CB AXIN2 AXIN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
PPP1R14BUncharacterized protein. (208 aa)
BIRC5Uncharacterized protein. (147 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MLH1MutL homolog 1. (756 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (167 aa)
RALGDSUncharacterized protein. (909 aa)
DCCDCC netrin 1 receptor. (1352 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
TCF7Transcription factor 7. (496 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
APCAPC regulator of WNT signaling pathway. (2864 aa)
ENSMNEP00000041867Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RALBRAS like proto-oncogene B. (212 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
RHOARas homolog family member A. (193 aa)
AXIN1Axin 1. (867 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
ENSMNEP00000036315Uncharacterized protein. (182 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ENSMNEP00000034090Ras-GEF domain-containing protein. (470 aa)
EREGEpiregulin. (169 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1230 aa)
TCF7L2Transcription factor 7 like 2. (523 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RAC1Rac family small GTPase 1. (211 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
ENSMNEP00000028956Uncharacterized protein. (185 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
TGFATransforming growth factor alpha. (166 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RHOCRas homolog family member C. (193 aa)
AREGAmphiregulin. (274 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSMNEP00000019824Uncharacterized protein. (194 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
RAC2Rac family small GTPase 2. (192 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PMAIP1Uncharacterized protein. (133 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
EPGNEpithelial mitogen. (154 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSMNEP00000012161Ras-GEF domain-containing protein. (530 aa)
ENSMNEP00000011545Uncharacterized protein. (81 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
ENSMNEP00000009362Ras-GEF domain-containing protein. (509 aa)
RALARAS like proto-oncogene A. (206 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
RAC3Rac family small GTPase 3. (192 aa)
PIK3R2Uncharacterized protein. (668 aa)
LOC105480640Ras-GEF domain-containing protein. (429 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
LOC105492342Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
ENSMNEP00000005419Uncharacterized protein. (114 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
LOC105477715Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC105495023Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
LOC105477037Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSMNEP00000004019Uncharacterized protein; Belongs to the peptidase C14A family. (242 aa)
LOC105486922Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
POLKDNA polymerase kappa. (870 aa)
ENSMNEP00000002161Uncharacterized protein. (142 aa)
BBC3BCL2 binding component 3. (261 aa)
LOC105495842Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
LOC105497820Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC105491771Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC105464688Ras-GEF domain-containing protein. (387 aa)
CTNNB1Catenin beta 1. (781 aa)
ERASES cell expressed Ras. (233 aa)
LOC105487609Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RGL4Ral guanine nucleotide dissociation stimulator like 4. (471 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
AXIN2Axin 2. (844 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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