STRINGSTRING
PLD2 PLD2 CASP9 CASP9 ARAF ARAF RPS6KB2 RPS6KB2 ENSMNEP00000016378 ENSMNEP00000016378 CDK4 CDK4 MAPK3 MAPK3 TGFBR1 TGFBR1 SMAD4 SMAD4 MAPK8 MAPK8 CHUK CHUK ENSMNEP00000012161 ENSMNEP00000012161 RB1 RB1 MAPK1 MAPK1 ENSMNEP00000011554 ENSMNEP00000011554 ENSMNEP00000011545 ENSMNEP00000011545 NFKB1 NFKB1 BAK1 BAK1 MTOR MTOR DDB2 DDB2 ENSMNEP00000009362 ENSMNEP00000009362 RALA RALA RAD51 RAD51 GADD45A GADD45A RAC3 RAC3 PIK3R2 PIK3R2 LOC105480640 LOC105480640 MAP2K1 MAP2K1 E2F1 E2F1 BRAF BRAF EGFR EGFR ENSMNEP00000004647 ENSMNEP00000004647 POLK POLK ARHGEF6 ARHGEF6 PLD1 PLD1 BCL2L1 BCL2L1 CDKN1A CDKN1A JAK1 JAK1 STAT1 STAT1 LOC105464688 LOC105464688 ERAS ERAS RGL4 RGL4 PIK3CB PIK3CB IKBKG IKBKG AKT1 AKT1 BRCA2 BRCA2 BAX BAX ENSMNEP00000026276 ENSMNEP00000026276 PIK3CA PIK3CA ENSMNEP00000019824 ENSMNEP00000019824 EGF EGF AKT3 AKT3 RAC2 RAC2 PPP1R14B PPP1R14B ERBB2 ERBB2 KRAS KRAS RPS6KB1 RPS6KB1 ENSMNEP00000045127 ENSMNEP00000045127 CDKN2A CDKN2A BAD BAD RALGDS RALGDS E2F3 E2F3 TGFB3 TGFB3 TGFB2 TGFB2 MAPK10 MAPK10 TGFB1 TGFB1 GADD45G GADD45G RALB RALB E2F2 E2F2 MAPK9 MAPK9 PIK3R3 PIK3R3 ENSMNEP00000038642 ENSMNEP00000038642 RALBP1 RALBP1 STAT3 STAT3 SMAD3 SMAD3 ENSMNEP00000036315 ENSMNEP00000036315 VEGFA VEGFA TGFBR2 TGFBR2 CCND1 CCND1 CDC42 CDC42 CDK6 CDK6 RAF1 RAF1 ENSMNEP00000034090 ENSMNEP00000034090 IKBKB IKBKB RAC1 RAC1 PIK3CD PIK3CD TP53 TP53 PIK3R1 PIK3R1 GADD45B GADD45B ENSMNEP00000029022 ENSMNEP00000029022 ENSMNEP00000028956 ENSMNEP00000028956 AKT2 AKT2 RELA RELA SMAD2 SMAD2 ENSMNEP00000027902 ENSMNEP00000027902 TGFA TGFA ENSMNEP00000027485 ENSMNEP00000027485
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLD2Phospholipase. (933 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (260 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSMNEP00000012161Ras-GEF domain-containing protein. (530 aa)
RB1RB transcriptional corepressor 1. (928 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSMNEP00000011554Uncharacterized protein. (157 aa)
ENSMNEP00000011545Uncharacterized protein. (81 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
ENSMNEP00000009362Ras-GEF domain-containing protein. (509 aa)
RALARAS like proto-oncogene A. (206 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (332 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
RAC3Rac family small GTPase 3. (192 aa)
PIK3R2Uncharacterized protein. (668 aa)
LOC105480640Ras-GEF domain-containing protein. (429 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
E2F1E2F transcription factor 1. (437 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ENSMNEP00000004647Uncharacterized protein. (185 aa)
POLKDNA polymerase kappa. (870 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
PLD1Phospholipase. (1074 aa)
BCL2L1BCL2 like 1. (233 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
LOC105464688Ras-GEF domain-containing protein. (387 aa)
ERASES cell expressed Ras. (233 aa)
RGL4Ral guanine nucleotide dissociation stimulator like 4. (471 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BRCA2BRCA2 DNA repair associated. (3426 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ENSMNEP00000026276Rho-GAP domain-containing protein. (556 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSMNEP00000019824Uncharacterized protein. (194 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAC2Rac family small GTPase 2. (192 aa)
PPP1R14BUncharacterized protein. (208 aa)
ERBB2Receptor protein-tyrosine kinase. (1390 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ENSMNEP00000045127Uncharacterized protein. (183 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (160 aa)
BADBCL2 associated agonist of cell death. (167 aa)
RALGDSUncharacterized protein. (909 aa)
E2F3E2F transcription factor 3. (465 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RALBRAS like proto-oncogene B. (212 aa)
E2F2E2F transcription factor 2. (439 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
ENSMNEP00000038642Rho-GAP domain-containing protein. (555 aa)
RALBP1Rho-GAP domain-containing protein. (539 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ENSMNEP00000036315Uncharacterized protein. (182 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (452 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CDC42Uncharacterized protein. (191 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ENSMNEP00000034090Ras-GEF domain-containing protein. (470 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RAC1Rac family small GTPase 1. (211 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
ENSMNEP00000029022Uncharacterized protein. (185 aa)
ENSMNEP00000028956Uncharacterized protein. (185 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
TGFATransforming growth factor alpha. (166 aa)
ENSMNEP00000027485Uncharacterized protein. (118 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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