STRINGSTRING
MLH1 MLH1 PPP1R14B PPP1R14B PDPK1 PDPK1 ERBB2 ERBB2 CSDE1 CSDE1 CTNNA2 CTNNA2 KRAS KRAS TCF7L1 TCF7L1 NRAS NRAS BAD BAD MAP2K2 MAP2K2 SOS1 SOS1 TCF7 TCF7 APC APC LEF1 LEF1 CTNNA1 CTNNA1 GADD45G GADD45G AKT3 AKT3 PIK3R3 PIK3R3 ENSMNEP00000038522 ENSMNEP00000038522 AXIN1 AXIN1 CTNNA3 CTNNA3 CCND1 CCND1 RAF1 RAF1 CDH1 CDH1 FOXO3 FOXO3 TCF7L2 TCF7L2 HRAS HRAS PIK3CD PIK3CD TP53 TP53 PIK3R1 PIK3R1 GADD45B GADD45B AKT2 AKT2 ENSMNEP00000027902 ENSMNEP00000027902 GRB2 GRB2 AKT1 AKT1 BAX BAX PIK3CA PIK3CA ENSMNEP00000019824 ENSMNEP00000019824 EGF EGF APC2 APC2 CASP9 CASP9 ELK1 ELK1 ARAF ARAF ENSMNEP00000016378 ENSMNEP00000016378 MAPK3 MAPK3 MAPK1 MAPK1 ENSMNEP00000011545 ENSMNEP00000011545 ILK ILK BAK1 BAK1 DDB2 DDB2 GADD45A GADD45A PIK3R2 PIK3R2 PTEN PTEN SOS2 SOS2 MAP2K1 MAP2K1 GSK3B GSK3B BRAF BRAF EGFR EGFR MYC MYC POLK POLK TPTE2 TPTE2 CDKN1A CDKN1A ENSMNEP00000001669 ENSMNEP00000001669 ENSMNEP00000001215 ENSMNEP00000001215 CTNNB1 CTNNB1 ERAS ERAS PIK3CB PIK3CB AXIN2 AXIN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MLH1MutL homolog 1. (756 aa)
PPP1R14BUncharacterized protein. (208 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (582 aa)
ERBB2Receptor protein-tyrosine kinase. (1390 aa)
CSDE1Cold shock domain containing E1. (844 aa)
CTNNA2Catenin alpha 2. (953 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
TCF7Transcription factor 7. (496 aa)
APCAPC regulator of WNT signaling pathway. (2864 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
CTNNA1Catenin alpha 1. (906 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
ENSMNEP00000038522Uncharacterized protein. (795 aa)
AXIN1Axin 1. (867 aa)
CTNNA3Catenin alpha 3. (895 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
FOXO3Forkhead box O3. (716 aa)
TCF7L2Transcription factor 7 like 2. (523 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSMNEP00000019824Uncharacterized protein. (194 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
ELK1ETS transcription factor ELK1. (428 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSMNEP00000011545Uncharacterized protein. (81 aa)
ILKIntegrin linked kinase. (528 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PIK3R2Uncharacterized protein. (668 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
POLKDNA polymerase kappa. (870 aa)
TPTE2Uncharacterized protein. (558 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSMNEP00000001669Uncharacterized protein. (77 aa)
ENSMNEP00000001215Uncharacterized protein. (87 aa)
CTNNB1Catenin beta 1. (781 aa)
ERASES cell expressed Ras. (233 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
AXIN2Axin 2. (844 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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