STRINGSTRING
TGFA TGFA PIK3CB PIK3CB ERAS ERAS ENSMNEP00000001215 ENSMNEP00000001215 IGF1 IGF1 ENSMNEP00000001669 ENSMNEP00000001669 CALML3 CALML3 CDKN1A CDKN1A TPTE2 TPTE2 PLCG2 PLCG2 POLK POLK EGFR EGFR BRAF BRAF PRKCB PRKCB E2F1 E2F1 MAP2K1 MAP2K1 SOS2 SOS2 PTEN PTEN PIK3R2 PIK3R2 GADD45A GADD45A DDB2 DDB2 MTOR MTOR BAK1 BAK1 MAPK1 MAPK1 RB1 RB1 CAMK1G CAMK1G CAMK4 CAMK4 MAPK3 MAPK3 CDK4 CDK4 ENSMNEP00000016378 ENSMNEP00000016378 ENSMNEP00000016414 ENSMNEP00000016414 ARAF ARAF CALML4 CALML4 PDGFRB PDGFRB CEP152 CEP152 EGF EGF PIK3CA PIK3CA PDGFRA PDGFRA BAX BAX SHC4 SHC4 PVALEF PVALEF CALML6 CALML6 CAMK1 CAMK1 SHC3 SHC3 CALM2 CALM2 CAMK2D CAMK2D CSDE1 CSDE1 KRAS KRAS CDKN2A CDKN2A NRAS NRAS AKT1 AKT1 CAMK2A CAMK2A MAP2K2 MAP2K2 SOS1 SOS1 CALM1 CALM1 E2F3 E2F3 PLCG1 PLCG1 GADD45G GADD45G PDGFA PDGFA AKT3 AKT3 PIK3R3 PIK3R3 MDM2 MDM2 E2F2 E2F2 CAMK2G CAMK2G CCND1 CCND1 CDK6 CDK6 RAF1 RAF1 SHC2 SHC2 GRB2 GRB2 SHC1 SHC1 CAMK1D CAMK1D ARSI ARSI CAMK2B CAMK2B HRAS HRAS PIK3CD PIK3CD TP53 TP53 PIK3R1 PIK3R1 GADD45B GADD45B IGF1R IGF1R CALM3 CALM3 PDGFB PDGFB AKT2 AKT2 PRKCG PRKCG PRKCA PRKCA ENSMNEP00000027902 ENSMNEP00000027902
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFATransforming growth factor alpha. (166 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ERASES cell expressed Ras. (233 aa)
ENSMNEP00000001215Uncharacterized protein. (87 aa)
IGF1Insulin like growth factor 1. (208 aa)
ENSMNEP00000001669Uncharacterized protein. (77 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
TPTE2Uncharacterized protein. (558 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
POLKDNA polymerase kappa. (870 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
E2F1E2F transcription factor 1. (437 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PIK3R2Uncharacterized protein. (668 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
RB1RB transcriptional corepressor 1. (928 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (260 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
ENSMNEP00000016414Uncharacterized protein; Belongs to the calmodulin family. (179 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
CALML4Calmodulin like 4. (193 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CEP152Centrosomal protein 152. (1703 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
SHC4SHC adaptor protein 4. (630 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
CALML6Calmodulin like 6. (181 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
SHC3SHC adaptor protein 3. (598 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (160 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
CALM1Calmodulin 1. (149 aa)
E2F3E2F transcription factor 3. (465 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
E2F2E2F transcription factor 2. (439 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SHC2Uncharacterized protein. (572 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SHC1SHC adaptor protein 1. (584 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
ARSIArylsulfatase family member I. (569 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CALM3Calmodulin 3. (149 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.