STRINGSTRING
CSDE1 CSDE1 ERAS ERAS CTNNB1 CTNNB1 CDKN1A CDKN1A POLK POLK MYC MYC BRAF BRAF MAP2K1 MAP2K1 PPARG PPARG TFG TFG ENSMNEP00000008869 ENSMNEP00000008869 GADD45A GADD45A RXRA RXRA DDB2 DDB2 BAK1 BAK1 MAPK1 MAPK1 CCDC6 CCDC6 MAPK3 MAPK3 ENSMNEP00000016378 ENSMNEP00000016378 ENSMNEP00000020788 ENSMNEP00000020788 RXRB RXRB TPR TPR RET RET BAX BAX RXRG RXRG PAX8 PAX8 ENSMNEP00000027902 ENSMNEP00000027902 GADD45B GADD45B TP53 TP53 HRAS HRAS TCF7L2 TCF7L2 ENSMNEP00000033545 ENSMNEP00000033545 CDH1 CDH1 CCND1 CCND1 NCOA4 NCOA4 ENSMNEP00000037049 ENSMNEP00000037049 GADD45G GADD45G LEF1 LEF1 ENSMNEP00000041856 ENSMNEP00000041856 NTRK1 NTRK1 TCF7 TCF7 MAP2K2 MAP2K2 ENSMNEP00000043465 ENSMNEP00000043465 NRAS NRAS TCF7L1 TCF7L1 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSDE1Cold shock domain containing E1. (844 aa)
ERASES cell expressed Ras. (233 aa)
CTNNB1Catenin beta 1. (781 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
POLKDNA polymerase kappa. (870 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TFGTrafficking from ER to golgi regulator. (400 aa)
ENSMNEP00000008869Uncharacterized protein; Belongs to the tropomyosin family. (231 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
RXRARetinoid X receptor alpha. (523 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
CCDC6Coiled-coil domain containing 6. (474 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
ENSMNEP00000020788Uncharacterized protein. (469 aa)
RXRBRetinoid X receptor beta. (537 aa)
TPRTranslocated promoter region, nuclear basket protein. (2439 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1112 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
RXRGRetinoid X receptor gamma. (463 aa)
PAX8Paired box 8. (544 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TCF7L2Transcription factor 7 like 2. (523 aa)
ENSMNEP00000033545Uncharacterized protein. (200 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
NCOA4Nuclear receptor coactivator 4. (651 aa)
ENSMNEP00000037049Uncharacterized protein. (188 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
ENSMNEP00000041856PB1 domain-containing protein. (318 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
TCF7Transcription factor 7. (496 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ENSMNEP00000043465Uncharacterized protein. (145 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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