STRINGSTRING
AKT3 AKT3 PPP1R14B PPP1R14B FGF2 FGF2 CSDE1 CSDE1 KRAS KRAS FGF3 FGF3 CDKN2A CDKN2A NRAS NRAS BAD BAD FGF8 FGF8 MAP2K2 MAP2K2 FGF22 FGF22 E2F3 E2F3 GADD45G GADD45G PDGFA PDGFA PIK3R3 PIK3R3 FGF4 FGF4 FGF17 FGF17 MDM2 MDM2 E2F2 E2F2 CCND1 CCND1 CDK6 CDK6 RAF1 RAF1 CDH1 CDH1 HGF HGF FGF18 FGF18 GALK2 GALK2 HRAS HRAS PIK3CD PIK3CD TP53 TP53 PIK3R1 PIK3R1 GADD45B GADD45B MET MET IGF1R IGF1R PDGFB PDGFB AKT2 AKT2 ENSMNEP00000027902 ENSMNEP00000027902 AKT1 AKT1 FGF16 FGF16 MITF MITF PDGFD PDGFD FGF19 FGF19 FGF20 FGF20 BAX BAX FGF21 FGF21 PDGFRA PDGFRA FGF7 FGF7 FGF9 FGF9 PIK3CA PIK3CA FGF10 FGF10 FGFR1 FGFR1 ENSMNEP00000019824 ENSMNEP00000019824 EGF EGF PDGFRB PDGFRB ARAF ARAF FGF1 FGF1 ENSMNEP00000016378 ENSMNEP00000016378 CDK4 CDK4 MAPK3 MAPK3 RB1 RB1 MAPK1 MAPK1 ENSMNEP00000011545 ENSMNEP00000011545 BAK1 BAK1 DDB2 DDB2 FGF5 FGF5 GADD45A GADD45A FGF6 FGF6 PIK3R2 PIK3R2 PTEN PTEN MAP2K1 MAP2K1 FGF23 FGF23 E2F1 E2F1 BRAF BRAF EGFR EGFR PDGFC PDGFC POLK POLK TPTE2 TPTE2 CDKN1A CDKN1A ENSMNEP00000001669 ENSMNEP00000001669 IGF1 IGF1 ENSMNEP00000001215 ENSMNEP00000001215 ERAS ERAS PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP1R14BUncharacterized protein. (208 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (357 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (160 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (167 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
E2F3E2F transcription factor 3. (465 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
E2F2E2F transcription factor 2. (439 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GALK2Galactokinase 2. (451 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1403 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MITFMelanocyte inducing transcription factor. (517 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
ENSMNEP00000019824Uncharacterized protein. (194 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (260 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RB1RB transcriptional corepressor 1. (928 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSMNEP00000011545Uncharacterized protein. (81 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3R2Uncharacterized protein. (668 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
E2F1E2F transcription factor 1. (437 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
POLKDNA polymerase kappa. (870 aa)
TPTE2Uncharacterized protein. (558 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSMNEP00000001669Uncharacterized protein. (77 aa)
IGF1Insulin like growth factor 1. (208 aa)
ENSMNEP00000001215Uncharacterized protein. (87 aa)
ERASES cell expressed Ras. (233 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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